polySUMO2,3-K559-HDAC4 [nucleoplasm]

Stable Identifier
R-HSA-4616029
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
HDAC4_HUMAN, Histone deacetylase 4
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
12032081 The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

Dejean, A, Mathieu, M, Müller, S, Seeler, JS, Gast, A, Kirsh, O, Harel-Bellan, A, Melchior, F, Kouzarides, T, Pichler, A, Miska, E

EMBO J. 2002
External Reference Information
External Reference
UniProt:P56524 HDAC4
Gene Names
HDAC4, KIAA0288
Chain
chain:1-1084
Reference Genes
BioGPS Gene:9759 HDAC4
COSMIC (genes):HDAC4 HDAC4
CTD Gene:9759 HDAC4
dbSNP Gene:9759 HDAC4
ENSEMBL:ENSG00000068024 HDAC4
ENSEMBL_homo_sapiens_GENE:ENSG00000068024.18 HDAC4
HGNC:14063 HDAC4
KEGG Gene (Homo sapiens):9759 HDAC4
Monarch:9759 HDAC4
NCBI Gene:9759 HDAC4
OMIM:605314 HDAC4
UCSC:P56524 HDAC4
Reference Transcript
Other Identifiers
11743453_s_at
11750121_a_at
11750579_a_at
11752170_a_at
1554322_PM_a_at
1554322_a_at
16910020
204225_PM_at
204225_at
228813_PM_at
228813_at
2606043
2606044
2606045
2606046
2606047
2606048
2606049
2606050
2606051
2606052
2606053
2606054
2606055
2606056
2606066
2606072
2606089
2606092
2606099
2606111
2606113
2606131
2606135
2606136
2606143
2606155
2606164
2606176
2606177
2606183
2606184
2606186
2606188
2606194
2606202
2606207
2606220
2606221
2606222
2606236
2606293
2606299
2606373
38271_at
76602_at
8060030
9759
A_23_P210048
A_24_P359856
A_24_P359859
A_24_P8892
GE53132
GO:0000118
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0002376
GO:0003012
GO:0003677
GO:0003824
GO:0004407
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005975
GO:0006091
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006476
GO:0006954
GO:0007399
GO:0008270
GO:0008284
GO:0010558
GO:0010832
GO:0010944
GO:0014894
GO:0014898
GO:0016575
GO:0016607
GO:0016740
GO:0016787
GO:0016925
GO:0017053
GO:0019789
GO:0019899
GO:0023052
GO:0030154
GO:0030183
GO:0030955
GO:0033235
GO:0033558
GO:0034983
GO:0036211
GO:0042113
GO:0042393
GO:0042802
GO:0042826
GO:0043226
GO:0043229
GO:0043393
GO:0043433
GO:0045814
GO:0045820
GO:0045893
GO:0045944
GO:0046872
GO:0048856
GO:0050896
GO:0051091
GO:0055086
GO:0060090
GO:0060337
GO:0061629
GO:0070555
GO:0098542
GO:0140096
GO:0140297
GO:1901135
HMNXSV003054853
Hs.91400.1.S1_3p_at
Hs2.91400.2.S1_3p_s_at
ILMN_1764396
PH_hs_0032216
TC02002922.hg
g13259519_3p_at
Participates
as an output of
Other forms of this molecule
monoSUMO1-K559-HDAC4 [nucleoplasm]
HDAC4 [nucleoplasm]
Inferred To
hdaD [nucleoplasm] (Dictyostelium discoideum)
Homologues of polySUMO2,3-K559-HDAC4 [nucleoplasm] (Dictyostelium discoideum)
Homologues of polySUMO2,3-K559-HDAC4 [nucleoplasm] (Plasmodium falciparum)
polySUMO2,3-K559-HDAC4 [nucleoplasm] (Bos taurus)
polySUMO2,3-K559-HDAC4 [nucleoplasm] (Dictyostelium discoideum)
polySUMO2,3-K559-HDAC4 [nucleoplasm] (Drosophila melanogaster)
polySUMO2,3-K559-HDAC4 [nucleoplasm] (Gallus gallus)
polySUMO2,3-K559-HDAC4 [nucleoplasm] (Mus musculus)
polySUMO2,3-K559-HDAC4 [nucleoplasm] (Plasmodium falciparum)
polySUMO2,3-K559-HDAC4 [nucleoplasm] (Rattus norvegicus)
polySUMO2,3-K559-HDAC4 [nucleoplasm] (Sus scrofa)
Modified Residues
Name
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 559
Coordinate
559
Modification
polySUMO2,3 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Investigational
HPA
GeneCards
Ensembl
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (32)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P61981 YWHAG  1 0.947 15
 UniProt:P63104 YWHAZ  2 0.899 9
 UniProt:Q04917 YWHAH  1 0.886 10
 UniProt:P62258 YWHAE  1 0.865 9
 UniProt:P31947 SFN  1 0.783 8
 UniProt:P31946 YWHAB  1 0.774 6
 UniProt:P27348 YWHAQ  1 0.774 6
 UniProt:P56524 HDAC4  3 0.655 4
 UniProt:Q8AZK7 EBNA5      0.612 5
 UniProt:A9UHW6 MI4GD      0.602 4
 UniProt:Q13761 RUNX3  7 0.558 9
 UniProt:Q01850 CDR2      0.556 3
 UniProt:O95967 EFEMP2  1 0.556 3
 UniProt:Q9H9E1 ANRA2      0.556 3
 UniProt:Q8ND90 PNMA1      0.556 3
 UniProt:Q6NUQ1 RINT1  1 0.556 3
 UniProt:Q96JN2-2 CCDC136      0.556 3
 UniProt:O95751 LDOC1      0.556 3
 UniProt:Q5JR59 MTUS2      0.556 3
 UniProt:O76015 KRT38  1 0.556 3
 UniProt:Q6A162 KRT40  1 0.556 3
 UniProt:Q15323 KRT31  1 0.556 3
 UniProt:Q08379 GOLGA2  3 0.556 3
 UniProt:P10275 AR  4 0.544 4
 UniProt:O75376 NCOR1  2 0.527 2
 UniProt:O15379 HDAC3  2 0.527 2
 UniProt:Q9HCU9 BRMS1  1 0.524 2
 UniProt:P08393 ICP0      0.524 3
 UniProt:P63279 UBE2I  9 0.508 3
 UniProt:P41182 BCL6  1 0.499 3
 UniProt:Q06413 MEF2C  3 0.491 2
 UniProt:Q02078 MEF2A  3 0.489 2
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