Reactome | polySUMO2,3-K559-HDAC4 [nucleoplasm]

polySUMO2,3-K559-HDAC4 [nucleoplasm]

Stable Identifier

R-HSA-4616029

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HDAC4_HUMAN, Histone deacetylase 4

Locations in the PathwayBrowser for interactor UniProt:O76015 KRT38

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Literature References

PubMed ID	Title	Journal	Year
12032081	The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase Dejean, A, Mathieu, M, Müller, S, Seeler, JS, Gast, A, Kirsh, O, Harel-Bellan, A, Melchior, F, Kouzarides, T, Pichler, A, Miska, E	EMBO J.	2002

External Reference Information

External Reference

UniProt:P56524 HDAC4

Gene Names

HDAC4, KIAA0288

Chain

chain:1-1084

Reference Genes

BioGPS Gene:9759 HDAC4

COSMIC (genes):HDAC4 HDAC4

CTD Gene:9759 HDAC4

dbSNP Gene:9759 HDAC4

ENSEMBL:ENSG00000068024 HDAC4

HGNC:14063 HDAC4

KEGG:hsa:9759 HDAC4

Monarch:9759 HDAC4

NCBI Gene:9759 HDAC4

OMIM:605314 HDAC4

UCSC:P56524 HDAC4

Reference Transcript

RefSeq:NM_006037.3 HDAC4

Participates

as an output of

RANBP2 SUMOylates HDAC4 with SUMO2,3 (Homo sapiens)

Other forms of this molecule

HDAC4 [nucleoplasm]

monoSUMO1-K559-HDAC4 [nucleoplasm]

Inferred To

hdaD [nucleoplasm] (Dictyostelium discoideum)

Homologues of polySUMO2,3-K559-HDAC4 [nucleoplasm] (Dictyostelium discoideum)

Homologues of polySUMO2,3-K559-HDAC4 [nucleoplasm] (Plasmodium falciparum)

polySUMO2,3-K559-HDAC4 [nucleoplasm] (Bos taurus)

polySUMO2,3-K559-HDAC4 [nucleoplasm] (Dictyostelium discoideum)

polySUMO2,3-K559-HDAC4 [nucleoplasm] (Drosophila melanogaster)

polySUMO2,3-K559-HDAC4 [nucleoplasm] (Gallus gallus)

polySUMO2,3-K559-HDAC4 [nucleoplasm] (Mus musculus)

polySUMO2,3-K559-HDAC4 [nucleoplasm] (Plasmodium falciparum)

polySUMO2,3-K559-HDAC4 [nucleoplasm] (Rattus norvegicus)

polySUMO2,3-K559-HDAC4 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 559

Coordinate

559

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_006028.2

Guide to Pharmacology - Targets

2659

ENSEMBL

ENSG00000068024, ENSP00000264606, ENST00000345617

OpenTargets

ENSG00000068024

ZINC - FDA approved

HDAC4_HUMAN

ZINC - Substances

HDAC4_HUMAN

ZINC - Biogenic

HDAC4_HUMAN

ZINC target

P56524

PRO

P56524

GlyGen

P56524

PDB

3UXG, 3UZD, 5A2S, 6FYZ, 7XUZ, 2VQW, 5ZOP, 2VQQ, 4CBY, 4CBT, 2VQM, 2VQV, 2VQO, 2VQJ, 3V31, 2H8N, 2O94, 8PDE, 5ZOO

ZINC - Investigational

HDAC4_HUMAN

GeneCards

HDAC4

HPA

ENSG00000068024-HDAC4

Pharos - Targets

P56524

Orphanet

HDAC4

ZINC - Predictions - Purchasable

HDAC4_HUMAN

HMDB Protein

HMDBP02195

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.947	15
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.899	9
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.886	10
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.865	9
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.783	8
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.774	6
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.774	6
UniProt:P56524 HDAC4	3	HDAC4 [nucleoplasm] (R-HSA-351581) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029)	0.655	4
UniProt:Q8AZK7 EBNA5			0.612	5
UniProt:A9UHW6 MI4GD			0.602	4
UniProt:Q13761 RUNX3	7	RUNX3 [nucleoplasm] (R-HSA-8865393) RUNX3 [cytosol] (R-HSA-8937797) Ac-K94,K171-RUNX3 [nucleoplasm] (R-HSA-8951965) PolyUb-K94,K148-RUNX3 [cytosol] (R-HSA-8952400) PolyUb-K94,K148-RUNX3 [nucleoplasm] (R-HSA-8952387) p-Y-RUNX3 [cytosol] (R-HSA-8937805) PolyUb-RUNX3 [nucleoplasm] (R-HSA-8952417)	0.558	9
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:O76015 KRT38	1	KRT38 [cytosol] (R-HSA-6809615)	0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:O95751 LDOC1			0.556	3
UniProt:Q96JN2-2 CCDC136			0.556	3
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.556	3
UniProt:Q8ND90 PNMA1			0.556	3
UniProt:Q9H9E1 ANRA2			0.556	3
UniProt:O95967 EFEMP2	1	EFEMP2 [extracellular region] (R-HSA-2161231)	0.556	3
UniProt:Q01850 CDR2			0.556	3
UniProt:P10275 AR	4	AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.544	4
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.527	2
UniProt:O75376 NCOR1	2	NCOR1 [nucleoplasm] (R-HSA-442501) NCOR1 [cytosol] (R-HSA-1253310)	0.527	2
UniProt:P08393 ICP0			0.524	3
UniProt:Q9HCU9 BRMS1	1	BRMS1 [nucleoplasm] (R-HSA-4650034)	0.524	2
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944)	0.508	3
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.499	3
UniProt:Q06413 MEF2C	3	MEF2C [nucleoplasm] (R-HSA-199938) p-S396-MEF2C [nucleoplasm] (R-HSA-199942) p-T293,T300,S387-MEF2C [nucleoplasm] (R-HSA-448838)	0.491	2
UniProt:Q02078 MEF2A	3	MEF2A [nucleoplasm] (R-HSA-199903) p-S408-MEF2A [nucleoplasm] (R-HSA-199909) p-T312,T319-MEF2A [nucleoplasm] (R-HSA-448834)	0.489	2

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