Reactome | monoSUMO1-K444,K476-HDAC1 [nucleoplasm]

monoSUMO1-K444,K476-HDAC1 [nucleoplasm]

Stable Identifier

R-HSA-4616030

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone deacetylase 1, HDAC1_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13547 HDAC1

Gene Names

HDAC1, RPD3L1

Chain

chain:1-482

Reference Genes

BioGPS Gene:3065 HDAC1

COSMIC (genes):HDAC1 HDAC1

CTD Gene:3065 HDAC1

dbSNP Gene:3065 HDAC1

ENSEMBL:ENSG00000116478 HDAC1

ENSEMBL:ENSG00000116478.12 HDAC1

HGNC:4852 HDAC1

KEGG Gene (Homo sapiens):3065 HDAC1

Monarch:3065 HDAC1

NCBI Gene:3065 HDAC1

OMIM:601241 HDAC1

Reference Transcript

RefSeq:NM_004964.2 HDAC1

Other Identifiers

11747406_a_at

11755718_s_at

16662077

201209_PM_at

201209_at

2328869

2328870

2328872

2328873

2328878

2328879

2328882

2328885

2328889

2328890

2328891

2328892

2328894

2328896

2328898

2328900

2381219

2927725

3065

38771_at

476_s_at

7899774

A_14_P114672

A_23_P114656

D50405_at

GE57241

GO:0000118

GO:0000122

GO:0000228

GO:0000785

GO:0000792

GO:0000976

GO:0000978

GO:0000979

GO:0001046

GO:0001222

GO:0002039

GO:0003677

GO:0003682

GO:0003714

GO:0003824

GO:0004407

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005829

GO:0006325

GO:0006338

GO:0006346

GO:0006351

GO:0006355

GO:0006357

GO:0006476

GO:0007492

GO:0007623

GO:0008284

GO:0009913

GO:0010628

GO:0010629

GO:0012501

GO:0016575

GO:0016580

GO:0016581

GO:0016787

GO:0017053

GO:0019899

GO:0021766

GO:0023052

GO:0030154

GO:0030182

GO:0030336

GO:0030512

GO:0031492

GO:0032922

GO:0032991

GO:0033558

GO:0035851

GO:0036120

GO:0036211

GO:0042475

GO:0042659

GO:0042733

GO:0042826

GO:0043025

GO:0043066

GO:0043124

GO:0043226

GO:0043922

GO:0045892

GO:0045893

GO:0045944

GO:0046872

GO:0048511

GO:0048661

GO:0048709

GO:0048714

GO:0048856

GO:0048870

GO:0051059

GO:0052548

GO:0060766

GO:0060789

GO:0061029

GO:0061198

GO:0061629

GO:0070888

GO:0070932

GO:0070933

GO:0090090

GO:0140096

GO:0140110

GO:0140297

GO:0160008

GO:0160009

GO:1900221

GO:1902455

GO:1902459

GO:1990841

GO:2000273

GO:2000736

GO:2001243

HMNXSV003006637

ILMN_1727458

PH_hs_0004954

TC01000427.hg

U50079_s_at

g13128859_3p_at

Participates

as an output of

SUMOylation of HDAC1 with SUMO1 (Homo sapiens)

Other forms of this molecule

HDAC1 [nucleoplasm]

Inferred To

monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (Danio rerio)

monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (Dictyostelium discoideum)

monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (Xenopus tropicalis)

Hdac1 [nucleoplasm] (Mus musculus)

Hdac1 [nucleoplasm] (Rattus norvegicus)

hda-1 [nucleoplasm] (Caenorhabditis elegans)

clr6 [nucleoplasm] (Schizosaccharomyces pombe)

HDAC1 [nucleoplasm] (Bos taurus)

HDAC1 [nucleoplasm] (Gallus gallus)

RPD3 [nucleoplasm] (Saccharomyces cerevisiae)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 444

Coordinate

444

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 476

Coordinate

476

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_004955.2

ZINC - World Drugs

HDAC1_HUMAN

Guide to Pharmacology - Targets

2658

OpenTargets

ENSG00000116478

ZINC - FDA approved

HDAC1_HUMAN

ZINC - Substances

HDAC1_HUMAN

ZINC - Biogenic

HDAC1_HUMAN

ZINC target

Q13547

PRO

Q13547

PDB

7AOA, 7AO9, 5ICN, 7SME, 6Z2J, 6Z2K, 4BKX, 7AO8

ZINC - Investigational

HDAC1_HUMAN

GeneCards

Q13547

HPA

ENSG00000116478-HDAC1

Ensembl

ENSG00000116478, ENSP00000362649, ENST00000373548

Pharos - Targets

Q13547

ZINC - Predictions - Purchasable

HDAC1_HUMAN

Orphanet

24588

Interactors (141)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.955	18
UniProt:O94776 MTA2	1	MTA2 [nucleoplasm] (R-HSA-4657009)	0.944	15
UniProt:Q92769 HDAC2	2	monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.937	16
UniProt:Q9UKL0 RCOR1	1	RCOR1 [nucleoplasm] (R-HSA-996766)	0.935	11
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.914	12
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.899	9
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.895	8
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.886	7
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.885	11
UniProt:Q8N108 MIER1			0.862	8
UniProt:Q9UBB5 MBD2	1	MBD2 [nucleoplasm] (R-HSA-427367)	0.839	6
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.823	6
UniProt:Q8WXI9 GATAD2B	1	GATAD2B [nucleoplasm] (R-HSA-3702079)	0.788	5
UniProt:Q9HCU9 BRMS1	1	BRMS1 [nucleoplasm] (R-HSA-4650034)	0.784	5
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.758	8
UniProt:Q92618 ZN516			0.737	8
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.737	7
UniProt:Q14865 ARID5B	1	ARID5B [nucleoplasm] (R-HSA-5423050)	0.728	6
UniProt:Q9NP50 SHCAF			0.728	6
UniProt:Q86YP4 GATAD2A	1	GATAD2A [nucleoplasm] (R-HSA-3702077)	0.725	4
UniProt:Q5PSV4 BRM1L			0.725	4
UniProt:Q6PJG2 MDEAS			0.725	5
UniProt:O75446 SAP30	1	SAP30 [nucleoplasm] (R-HSA-351693)	0.725	5
UniProt:Q9H7L9 SUDS3	2	K63polyUb-SUDS3 [nucleoplasm] (R-HSA-6782790) SUDS3 [nucleoplasm] (R-HSA-351696)	0.725	4
UniProt:P78371 CCT2	3	CCT2 [extracellular region] (R-HSA-6806220) CCT2 [cytosol] (R-HSA-390464) CCT2 [azurophil granule lumen] (R-HSA-6799356)	0.725	5
UniProt:Q9NP66 HM20A			0.725	5
UniProt:O14519 CDKA1			0.725	5
UniProt:Q9BTC8 MTA3	1	MTA3 [nucleoplasm] (R-HSA-4657013)	0.725	5
UniProt:Q9H147 TDIF1			0.725	5
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.713	7
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.69	4
UniProt:P68400 CSNK2A1	2	CSNK2A1 [nucleoplasm] (R-HSA-6805057) CSNK2A1 [cytosol] (R-HSA-201713)	0.688	3
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.688	3
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.677	6
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.656	6
UniProt:Q96N64 PWP2A			0.649	5
UniProt:P19838 NFKB1	8	NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.646	5
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.643	4
UniProt:O75182 SIN3B	1	SIN3B [nucleoplasm] (R-HSA-3006450)	0.643	3
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.643	4
UniProt:O15417 TNC18			0.643	3
UniProt:Q96QT6 PHF12			0.643	4
UniProt:Q9P2R6 RERE			0.643	3
UniProt:Q14687 GSE1			0.643	3
UniProt:Q9P0W2 HMG20B	1	HMG20B [nucleoplasm] (R-HSA-996745)	0.643	3
UniProt:Q99471 PFDN5	1	PFDN5 [cytosol] (R-HSA-379548)	0.643	4
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.643	4
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.643	4
UniProt:Q7Z589 EMSY			0.643	3
UniProt:Q8WUU5 GATD1			0.643	3
UniProt:Q9UBW7 ZMYM2	6	ZMYM2(1-913)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839016) ZMYM2(1-913)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604544) ZMYM2(1-1059)-p-4Y-FLT3(594-993) fusion [cytosol] (R-HSA-9703309) ZMYM2(1-1057)-p-5Y-FLT3(586-993) fusion [cytosol] (R-HSA-9703319) ZMYM2(1-1059)-FLT3(594-993) fusion [cytosol] (R-HSA-9703310) ZMYM2(1-1057)-FLT3(586-993) fusion [cytosol] (R-HSA-9703311)	0.643	3
UniProt:Q96PN7 TREF1			0.643	3
UniProt:P61758 VBP1	1	VBP1 [cytosol] (R-HSA-379543)	0.643	3
UniProt:Q8N680 ZBTB2			0.643	3
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.643	3
UniProt:O75362 ZNF217	1	ZNF217 [nucleoplasm] (R-HSA-9011738)	0.643	3
UniProt:Q13363 CTBP1	3	monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) CTBP1 [nucleoplasm] (R-HSA-212372)	0.643	7
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.643	4
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.642	3
UniProt:Q6PH81 CP087			0.623	4
UniProt:Q9C0K0 BC11B			0.602	3
UniProt:P26358 DNMT1	2	monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353) DNMT1 [nucleoplasm] (R-HSA-212181)	0.597	7
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.597	4
UniProt:Q05516 ZBTB16	1	ZBTB16 [cytosol] (R-HSA-976047)	0.589	2
UniProt:Q9Y618 NCOR2	2	monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904) NCOR2 [nucleoplasm] (R-HSA-442469)	0.589	2
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.589	2
UniProt:Q9NQX1 PRDM5			0.576	3
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.576	4
UniProt:O60341-1 KDM1A			0.564	2
UniProt:O95365 ZBT7A			0.564	2
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.564	2
UniProt:P17542 TAL1	1	TAL1 [nucleoplasm] (R-HSA-8956511)	0.558	5
UniProt:Q9UJW3 DNMT3L	1	DNMT3L [nucleoplasm] (R-HSA-5334123)	0.544	3
UniProt:Q99497 PARK7	7	monoSUMO1-K130-PARK7 [nucleoplasm] (R-HSA-4085351) PARK7 [nucleoplasm] (R-HSA-3900141) PolyUb-Misfolded PARK7 [late endosome lumen] (R-HSA-9660005) Misfolded PARK7 [cytosol] (R-HSA-9641100) Ub-Misfolded PARK7 [cytosol] (R-HSA-9641123) PolyUb-Misfolded PARK7 [cytosol] (R-HSA-9641128) PolyUb-Misfolded PARK7 [lysosomal lumen] (R-HSA-9659997)	0.537	4
UniProt:P22670 RFX1			0.534	2
UniProt:Q8N5A5 ZGPAT			0.532	3
UniProt:O60315 ZEB2	1	ZEB2 [nucleoplasm] (R-HSA-3108222)	0.532	9
UniProt:Q17R98 ZN827			0.527	2
UniProt:Q9P2K3-3 RCOR3			0.527	2
UniProt:Q92766 RREB1			0.527	2
UniProt:P85037 FOXK1	1	FOXK1 [nucleoplasm] (R-HSA-5689673)	0.527	2
UniProt:Q9HAJ7 SAP30L	1	SAP30L [nucleoplasm] (R-HSA-351698)	0.527	2
UniProt:Q8IZ40 RCOR2			0.527	2
UniProt:O15014 ZN609			0.527	2
UniProt:Q14839-2 CHD4			0.527	2
UniProt:Q9H9B1 EHMT1	1	EHMT1 [nucleoplasm] (R-HSA-1183226)	0.527	2
UniProt:Q4LE39-2 ARID4B			0.527	2
UniProt:Q9H0E3 SAP130	1	SAP130 [nucleoplasm] (R-HSA-3006732)	0.527	2
UniProt:Q14202 ZMYM3			0.527	2
UniProt:Q9R190 Mta2	1	Mta2 [nucleoplasm] (R-MMU-5096453)	0.527	2
UniProt:Q9UHV9 PFDN2	1	PFDN2 [cytosol] (R-HSA-379544)	0.527	2
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.527	3
UniProt:O60925 PFDN1	1	PFDN1 [cytosol] (R-HSA-379541)	0.527	2
UniProt:Q9P2K3 RCOR3			0.527	2
UniProt:P29375-2 KDM5A			0.527	2
UniProt:Q9Y232-2 CDYL			0.527	2
UniProt:Q96BD5-2 PHF21A			0.527	2
UniProt:Q9H2P0 ADNP			0.527	2
UniProt:Q8IWI9 MGA	1	MGA [nucleoplasm] (R-HSA-8953093)	0.527	2
UniProt:P50990 CCT8	5	CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [cytosol] (R-HSA-390449)	0.527	3
UniProt:IL2 ENSG00000109471			0.527	3
UniProt:O75182-2 SIN3B			0.527	2
UniProt:Q09028-2 RBBP4			0.527	2
UniProt:Q92610 ZN592			0.527	2
UniProt:Q8N344 MIER2			0.527	2
UniProt:P0C0S8 H2AC11	11	K63polyUb-HIST1H2AG [nucleoplasm] (R-HSA-6783237) Ub-HIST1H2AG [nucleoplasm] (R-HSA-6782508) Ack6-HIST1H2AG [nucleoplasm] (R-HSA-4568595) Me2aR30-HIST1H2AG [nucleoplasm] (R-HSA-5244582) MeR30-HIST1H2AG [nucleoplasm] (R-HSA-5244560) Me2aR4-HIST1H2AG [nucleoplasm] (R-HSA-5244587) MeR4-HIST1H2AG [nucleoplasm] (R-HSA-5244623) Me2aR12-HIST1H2AG [nucleoplasm] (R-HSA-5229305) MeR12-HIST1H2AG [nucleoplasm] (R-HSA-5229206) HIST1H2AG [nucleoplasm] (R-HSA-212084) Ack-HIST1H2AG [nucleoplasm] (R-HSA-4551311)	0.527	2
UniProt:O15212 PFDN6	1	PFDN6 [cytosol] (R-HSA-379547)	0.527	2
UniProt:Q9ULU4 ZMYD8			0.527	2
UniProt:Q9P281 BAHC1			0.527	2
UniProt:Q96KQ7-2 EHMT2			0.527	2
UniProt:Q96KM6 ZNF512B	1	ZNF512B [cytosol] (R-HSA-9715175)	0.527	2
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.527	2
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.527	2
UniProt:Q8N1G0 ZN687			0.527	2
UniProt:O75461 E2F6	2	E2F6 [nucleoplasm] (R-HSA-8953089) p-S12-E2F6 [nucleoplasm] (R-HSA-9007536)	0.527	2
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.527	3
UniProt:Q96K83 ZNF521	1	ZNF521 [nucleoplasm] (R-HSA-3222324)	0.527	2
UniProt:Q9H160 ING2	2	monoSUMO1-K195-ING2 [nucleoplasm] (R-HSA-4086075) ING2 [nucleoplasm] (R-HSA-3215167)	0.527	2
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.527	2
UniProt:P43355 MAGA1			0.524	2
UniProt:Q92841-4 DDX17			0.524	3
UniProt:O00422 SAP18	1	SAP18 [nucleoplasm] (R-HSA-351694)	0.524	2
UniProt:P03129 VE7			0.524	2
UniProt:Q66K89 E4F1			0.524	3
UniProt:P29128 ICP0			0.524	2
UniProt:Q9UIS9 MBD1	2	monoSUMO1-K499,K538-MBD1 [nucleoplasm] (R-HSA-4090331) MBD1 [nucleoplasm] (R-HSA-417134)	0.524	2
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.524	3
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.524	2
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.524	2
UniProt:P51858 HDGF	1	HDGF [nucleoplasm] (R-HSA-535593)	0.512	4
UniProt:Q92949 FOXJ1			0.508	2
UniProt:P51610 HCFC1	2	HCFC1 [nucleoplasm] (R-HSA-1592209) K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821)	0.499	2
IntAct:EBI-2694074 MDM2			0.499	2
UniProt:Q15466 NR0B2	1	NR0B2 [nucleoplasm] (R-HSA-376312)	0.499	2
UniProt:Q13227 GPS2	1	GPS2 [nucleoplasm] (R-HSA-351642)	0.499	2
UniProt:Q99684 GFI1	1	GFI1 [nucleoplasm] (R-HSA-2980932)	0.499	4
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.499	2
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.483	2
UniProt:A4PIW0 A4PIW0			0.462	3
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.462	2
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.462	4

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