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ub-AXIN2 [cytosol]
Stable Identifier
R-HSA-4641131
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Degradation of AXIN (Homo sapiens)
AXIN is ubiquitinated by SMURF2 (Homo sapiens)
ub-AXIN:SMURF2 [cytosol] (Homo sapiens)
ub-AXIN [cytosol] (Homo sapiens)
ub-AXIN2 [cytosol] (Homo sapiens)
Ubiquitinated AXIN is degraded by the proteasome (Homo sapiens)
ub-AXIN:SMURF2 [cytosol] (Homo sapiens)
ub-AXIN [cytosol] (Homo sapiens)
ub-AXIN2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2T1 AXIN2
Gene Names
AXIN2
Chain
chain:1-843
Reference Genes
BioGPS Gene:8313 AXIN2
COSMIC (genes):AXIN2 AXIN2
CTD Gene:8313 AXIN2
dbSNP Gene:8313 AXIN2
ENSEMBL:ENSG00000168646 AXIN2
HGNC:904 AXIN2
KEGG Gene (Homo sapiens):8313 AXIN2
Monarch:8313 AXIN2
NCBI Gene:8313 AXIN2
OMIM:604025 AXIN2
UCSC:Q9Y2T1 AXIN2
Reference Transcript
RefSeq:NM_004655.3 AXIN2
Other Identifiers
11718451_a_at
11718452_at
11718453_a_at
16847933
222695_s_at
222696_at
224176_s_at
224498_x_at
3767466
3767467
3767468
3767477
3767479
3767481
3767483
3767484
3767485
3767486
3767488
3767489
3767490
3767493
3767497
3767528
3767530
59763_s_at
64129_at
8017718
8313
90101_at
A_23_P148015
A_24_P298027
GE58341
GO:0001756
GO:0001934
GO:0001957
GO:0003139
GO:0003413
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006259
GO:0006464
GO:0006950
GO:0007049
GO:0007059
GO:0007165
GO:0007267
GO:0007275
GO:0008013
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0009056
GO:0009790
GO:0010718
GO:0010942
GO:0016055
GO:0019899
GO:0022607
GO:0030111
GO:0030154
GO:0030282
GO:0030877
GO:0031625
GO:0032423
GO:0032991
GO:0034613
GO:0034641
GO:0034655
GO:0042476
GO:0043226
GO:0043570
GO:0045668
GO:0048255
GO:0048646
GO:0048856
GO:0051276
GO:0061181
GO:0065003
GO:0070411
GO:0070602
GO:0090090
GO:0090263
GO:1904837
HMNXSV003007463
Hs.127337.0.S1_3p_a_at
Hs.127337.0.S3_3p_at
ILMN_1724480
TC17002855.hg
g13623398_3p_s_at
g6653583_3p_a_at
Participates
as a member of
ub-AXIN [cytosol] (Homo sapiens)
Other forms of this molecule
AXIN2 [cytosol]
RibC-AXIN2 [cytosol]
Ub-RibC-AXIN2 [cytosol]
Inferred To
AXIN2 [cytosol]
(Canis familiaris)
AXIN2 [cytosol]
(Gallus gallus)
AXIN2 [cytosol]
(Sus scrofa)
Axin2 [cytosol]
(Mus musculus)
Axin2 [cytosol]
(Rattus norvegicus)
Axn [cytosol]
(Drosophila melanogaster)
axin2 [cytosol]
(Danio rerio)
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 505
Coordinate
505
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_004646.3
OpenTargets
ENSG00000168646
ZINC - Substances
AXIN2_HUMAN
HPA
ENSG00000168646-AXIN2
GeneCards
Q9Y2T1
Ensembl
ENSP00000302625
,
ENSG00000168646
,
ENST00000307078
ZINC target
Q9Y2T1
PRO
Q9Y2T1
ZINC - Predictions - Purchasable
AXIN2_HUMAN
Orphanet
15346
Interactors (42)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62714 PPP2CB
4
MeL-PPP2CB [nucleoplasm]
(R-HSA-8857799)
p-Y307-PPP2CB [cytosol]
(R-HSA-8857935)
PPP2CB [nucleoplasm]
(R-HSA-165991)
PPP2CB [cytosol]
(R-HSA-165987)
0.645
4
UniProt:P49841 GSK3B
4
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [cytosol]
(R-HSA-2997551)
GSK3B [nucleoplasm]
(R-HSA-2022823)
0.643
3
UniProt:Q15583 TGIF1
1
TGIF1 [nucleoplasm]
(R-HSA-2186594)
0.567
5
UniProt:P35222 CTNNB1
33
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
Ub-K,p-Y-CTNNB1 [cytosol]
(R-HSA-8877006)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
0.564
2
UniProt:Q8NEF3-2 CCDC112
0.556
3
UniProt:Q3B820 F161A
0.556
3
UniProt:Q2TBE0 C19L2
0.556
3
UniProt:Q15560 TCEA2
0.556
3
UniProt:O75558 STX11
0.556
3
UniProt:O95985 TOP3B
0.556
3
UniProt:Q9BYR2 KRTAP4-5
1
KRTAP4-5 [cytosol]
(R-HSA-6809950)
0.556
3
UniProt:O75638-2 CTAG2
0.556
3
UniProt:P49721 PSMB2
2
PSMB2 [cytosol]
(R-HSA-68744)
PSMB2 [nucleoplasm]
(R-HSA-174335)
0.556
3
UniProt:Q9UKJ5 CHIC2
0.556
3
UniProt:Q2NKX9 CB068
0.556
3
UniProt:Q15973 ZNF124
1
ZNF124 [nucleoplasm]
(R-HSA-975017)
0.556
3
UniProt:Q9Y6W3 CAPN7
1
CAPN7 [cytosol]
(R-HSA-8848633)
0.556
3
UniProt:Q8N8B7-2 TCEANC
0.556
3
UniProt:Q13895 BYSL
2
BYSL [cytosol]
(R-HSA-6791518)
BYSL [nucleoplasm]
(R-HSA-6791526)
0.556
3
UniProt:Q8N3L3 TXLNB
0.556
3
UniProt:Q99728 BARD1
13
BARD1 C71Y [nucleoplasm]
(R-HSA-9700808)
BARD1 G623E [nucleoplasm]
(R-HSA-9699135)
BARD1 C53W [nucleoplasm]
(R-HSA-9700807)
BARD1 G623W [nucleoplasm]
(R-HSA-9699148)
BARD1 W34R [nucleoplasm]
(R-HSA-9699166)
p-T714,T734-BARD1 [nucleoplasm]
(R-HSA-5659846)
K6PolyUb,p-T714,T734-BARD1 [nucleoplasm]
(R-HSA-9707286)
K6PolyUb-BARD1 [nucleoplasm]
(R-HSA-9701024)
BARD1 [nucleoplasm]
(R-HSA-5659775)
BARD1 C83G [nucleoplasm]
(R-HSA-9699139)
BARD1 C50G [nucleoplasm]
(R-HSA-9699137)
BARD1 L44R [nucleoplasm]
(R-HSA-9699126)
BARD1 H68Y [nucleoplasm]
(R-HSA-9699151)
0.556
3
UniProt:P09067 HXB5
0.556
3
UniProt:Q15172 PPP2R5A
1
PPP2R5A [cytosol]
(R-HSA-196235)
0.556
3
UniProt:Q96SQ5 ZNF587
1
ZNF587 [nucleoplasm]
(R-HSA-2127565)
0.556
3
UniProt:Q14241 ELOA
1
TCEB3 [nucleoplasm]
(R-HSA-112421)
0.556
3
UniProt:P60014 KRTAP10-10
1
KRTAP10-10 [cytosol]
(R-HSA-6810293)
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:Q9Y297 BTRC
2
BTRC [nucleoplasm]
(R-HSA-3361753)
BTRC [cytosol]
(R-HSA-174237)
0.556
3
UniProt:Q9BWG6 SCNM1
0.556
3
UniProt:Q8TAU3 ZNF417
1
ZNF417 [nucleoplasm]
(R-HSA-1247539)
0.556
3
UniProt:Q9BYQ4 KRTAP9-2
1
KRTAP9-2 [cytosol]
(R-HSA-6809965)
0.556
3
UniProt:Q96EZ8 MCRS1
1
MCRS1 [nucleoplasm]
(R-HSA-3321849)
0.556
3
UniProt:Q9BVG8-5 KIFC3
0.556
3
UniProt:Q5T619 ZN648
0.556
3
UniProt:Q9BXS5 AP1M1
7
AP1M1 [Golgi membrane]
(R-HSA-350805)
AP1M1 [cytoplasmic vesicle membrane]
(R-HSA-351196)
AP1M1 [lysosomal membrane]
(R-HSA-432708)
AP1M1 [trans-Golgi network membrane]
(R-HSA-2130512)
AP1M1 [cytosol]
(R-HSA-167700)
AP1M1 [plasma membrane]
(R-HSA-6806311)
AP1M1 [specific granule membrane]
(R-HSA-6799365)
0.556
3
UniProt:Q9BZW7 TSG10
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:A2BDD9 A2BDD9
0.556
3
UniProt:P40222 TXLNA
1
TXLNA [cytosol]
(R-HSA-449124)
0.556
3
UniProt:P49840 GSK3A
3
p-S21-GSK3A [cytosol]
(R-HSA-198352)
GSK3A [cytosol]
(R-HSA-198326)
p-Y279-GSK3A [cytosol]
(R-HSA-9635490)
0.547
2
UniProt:Q8N944 AMER3
0.499
2
UniProt:Q9Y4X0 AMMR1
0.463
2
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