DVL1 is bound by the HECT ubiquitin ligase HECW1

Stable Identifier
R-HSA-4641155
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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HECW1, also known as NEDL1, is an HECT E3 ligase that co-immunoprecipitates with DVL1 upon cotransfection in Neuro2 cells and targets it for proteasomal degradation (Miyazaki et al, 2004).

Literature References
PubMed ID Title Journal Year
14684739 NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1

Miyazaki, K, Fujita, T, Ozaki, T, Kato, C, Kurose, Y, Sakamoto, M, Kato, S, Goto, T, Itoyama, Y, Aoki, M, Nakagawara, A

J. Biol. Chem. 2004
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