Reactome | ub-FZD8 [plasma membrane]

ub-FZD8 [plasma membrane]

Stable Identifier

R-HSA-4641183

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Frizzled-8, FZD8_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9H461 FZD8

Gene Names

FZD8

Chain

signal peptide:1-27, chain:28-694

Reference Genes

BioGPS Gene:8325 FZD8

COSMIC (genes):FZD8 FZD8

CTD Gene:8325 FZD8

dbSNP Gene:8325 FZD8

ENSEMBL:ENSG00000177283 FZD8

HGNC:4046 FZD8

KEGG:hsa:8325 FZD8

Monarch:8325 FZD8

NCBI Gene:8325 FZD8

OMIM:606146 FZD8

UCSC:Q9H461 FZD8

Reference Transcript

RefSeq:NM_031866.2 FZD8

Other Identifiers

11744233_at

11758064_s_at

16713309

216587_PM_s_at

216587_s_at

224325_PM_at

224325_at

227405_PM_s_at

227405_s_at

3285129

3285130

3285131

3285132

3285133

3285134

3285135

3285136

3285137

3285138

3285139

3285140

3285141

3285142

3285143

65690_at

7933075

8325

A_23_P396858

GE79238

GO:0001525

GO:0002376

GO:0004888

GO:0004930

GO:0005102

GO:0005515

GO:0005794

GO:0005886

GO:0007166

GO:0007186

GO:0016020

GO:0016055

GO:0017147

GO:0030154

GO:0030165

GO:0030182

GO:0031410

GO:0031625

GO:0033077

GO:0035567

GO:0042813

GO:0043226

GO:0060070

GO:0060089

GO:0098992

GO:1990851

HMNXSV003022378

HMNXSV003058101

Hs.302634.0.S1_3p_s_at

Hs.32659.0.A1_3p_s_at

ILMN_1729368

PH_hs_0015628

TC10001179.hg

g13623798_3p_at

g13623798_3p_x_at

Participates

as a candidate of

ub-FZD [plasma membrane] (Homo sapiens)

Other forms of this molecule

FZD8 [plasma membrane]

Inferred To

fzd8a [plasma membrane] (Danio rerio)

ub-FZD8 [plasma membrane] (Mus musculus)

ub-FZD8 [plasma membrane] (Rattus norvegicus)

fzd8 [plasma membrane] (Xenopus tropicalis)

FZD8 [plasma membrane] (Bos taurus)

FZD8 [plasma membrane] (Canis familiaris)

FZD8 [plasma membrane] (Sus scrofa)

cfz-2 [plasma membrane] (Caenorhabditis elegans)

Modified Residues

Name

ubiquitinylated lysine at unknown position

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

Guide to Pharmacology - Targets

236

ENSEMBL

ENSP00000363826, ENSG00000177283, ENST00000374694

OpenTargets

ENSG00000177283

GeneCards

FZD8

HPA

ENSG00000177283-FZD8

PRO

Q9H461

Pharos - Targets

Q9H461

GlyGen

Q9H461

HMDB Protein

HMDBP07704

PDB

5UN6, 8X0T, 5UN5, 6NDZ

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H8X2 IPPK	2	IPPK [cytosol] (R-HSA-1604598) IPPK [nucleoplasm] (R-HSA-2023949)	0.527	2
UniProt:P56704 WNT3A	10	N4GlycoAsn-PalmS WNT3A [plasma membrane] (R-HSA-3247807) N4GlycoAsn-PalmS WNT3A [extracellular region] (R-HSA-3247784) N4GlycoAsn-PalmS WNT3A [Golgi lumen] (R-HSA-3247832) N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen] (R-HSA-3238344) N4GlycoAsn-WNT3A [endoplasmic reticulum lumen] (R-HSA-3238231) WNT3A [endoplasmic reticulum lumen] (R-HSA-3238292) N4GlycoAsn-PalmS WNT3A [early endosome membrane] (R-HSA-5368483) N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane] (R-HSA-3781944) N4GlycoAsn-PalmS WNT3A [extracellular exosome] (R-HSA-3781968) WNT3A [extracellular region] (R-HSA-201710)	0.499	2