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RSPO4 [extracellular region]
Stable Identifier
R-HSA-4641197
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Regulation of FZD by ubiquitination (Homo sapiens)
RSPO:LGR binds ZNRF3 (Homo sapiens)
RSPO:LGR [plasma membrane] (Homo sapiens)
RSPO [extracellular region] (Homo sapiens)
RSPO4 [extracellular region] (Homo sapiens)
RSPO:LGR:ZNRF3,RNF43 [plasma membrane] (Homo sapiens)
RSPO:LGR [plasma membrane] (Homo sapiens)
RSPO [extracellular region] (Homo sapiens)
RSPO4 [extracellular region] (Homo sapiens)
RSPOs bind LGRs (Homo sapiens)
RSPO [extracellular region] (Homo sapiens)
RSPO4 [extracellular region] (Homo sapiens)
RSPO:LGR [plasma membrane] (Homo sapiens)
RSPO [extracellular region] (Homo sapiens)
RSPO4 [extracellular region] (Homo sapiens)
ZNRF3 autoubiquitinates to promote its internalization (Homo sapiens)
RSPO:LGR:ZNRF3,RNF43 [plasma membrane] (Homo sapiens)
RSPO:LGR [plasma membrane] (Homo sapiens)
RSPO [extracellular region] (Homo sapiens)
RSPO4 [extracellular region] (Homo sapiens)
RSPO:LGR:ub-ZNRF3,RNF43 [plasma membrane] (Homo sapiens)
RSPO [extracellular region] (Homo sapiens)
RSPO4 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q2I0M5 RSPO4
Gene Names
RSPO4, C20orf182
Chain
signal peptide:1-19, chain:20-234
Reference Genes
BioGPS Gene:343637 RSPO4
COSMIC (genes):RSPO4 RSPO4
CTD Gene:343637 RSPO4
dbSNP Gene:343637 RSPO4
ENSEMBL:ENSG00000101282 RSPO4
ENSEMBL_homo_sapiens_GENE:ENSG00000101282.9 RSPO4
HGNC:16175 RSPO4
KEGG Gene (Homo sapiens):343637 RSPO4
Monarch:343637 RSPO4
NCBI Gene:343637 RSPO4
OMIM:610573 RSPO4
UCSC:Q2I0M5 RSPO4
Reference Transcript
RefSeq:NM_001040007.2 RSPO4
RefSeq:NM_001029871.3 RSPO4
Other Identifiers
11727333_a_at
11742231_a_at
16916389
237423_PM_at
237423_at
343637
3894440
3894441
3894442
3894443
3894444
3894445
3894446
3894447
3894450
3894451
3894452
3894454
3894464
3894465
49062_at
8064407
A_33_P3251552
GE881554
GO:0005515
GO:0005576
GO:0008201
GO:0016055
GO:0023052
GO:0030177
GO:0035878
GO:0048856
GO:0050896
HMNXSV003002804
HMNXSV003039743
Hs.98183.0.A1_3p_at
ILMN_1750625
ILMN_2347249
PH_hs_0021559
TC20000547.hg
Participates
as a member of
RSPO [extracellular region] (Homo sapiens)
Inferred To
RSPO4 [extracellular region]
(Bos taurus)
RSPO4 [extracellular region]
(Canis familiaris)
RSPO4 [extracellular region]
(Gallus gallus)
RSPO4 [extracellular region]
(Sus scrofa)
Rspo4 [extracellular region]
(Mus musculus)
Rspo4 [extracellular region]
(Rattus norvegicus)
si:dkey-107i16.4 [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_001035096.1
,
NP_001025042.2
OpenTargets
ENSG00000101282
HPA
ENSG00000101282-RSPO4
GeneCards
Q2I0M5
Ensembl
ENSP00000383475
,
ENSG00000101282
,
ENST00000400634
,
ENSP00000217260
,
ENST00000217260
PRO
Q2I0M5
Pharos - Targets
Q2I0M5
Orphanet
15234
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
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