Reactome: A Curated Pathway Database

RSPO:LGR binds ZNRF3

Stable Identifier
R-HSA-4641205
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

RSPO1-4 increase the levels of FZD and LRP6 receptors and decrease the amount of ZNRF3 at the plasma membrane. RSPO-induced internalization of ZNRF3 depends on LGR and the ubiquitin ligase activity of ZNRF3, and RSPO has been shown to bind directly to the extracellular region of ZNRF3 in an LGR-independent manner. These data are consistent with a model where RSPO promotes an interaction between ZNRF3 and LGR proteins that is required for downregulation of the ubiquitin ligase. In support of this model, artificial dimerization of ZNRF3 and LGR bypasses the requirement for RSPO in ZNRF3 internalization (Hao et al, 2012).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events