TLE recruits HDAC1 to WNT promoters

Stable Identifier
R-HSA-4641231
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Groucho/TLE mediates repression of WNT target genes in part by recruiting a histone deacetlyase to the promoter. The weakly conserved central GP domain of Groucho/TLE has been shown to interact with the histone deacetylase RPD3/HDAC1 (Brantjes et al, 2001; Chen et al, 1999). Knockdown of rpd3 in Drosophila cells, or treatment of human or Drosophila cells with the histone deacetylase inhibitor Trichostatin A significantly decreases repression of a Groucho/TLE dependent reporter gene, and Groucho and RPD3 have been shown to co-localize to chromatin of target genes by ChIP leading to deacetylation of H3K9, H3K14, K4K5, H4K8 and H4K12 (Chen et al, 1999; Choi et al 1999; Winkler et al, 2010).

Literature References
PubMed ID Title Journal Year
20405012 Groucho-mediated repression may result from a histone deacetylase-dependent increase in nucleosome density

Winkler, CJ, Ponce, A, Courey, AJ

PLoS ONE 2010
10559189 The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription

Choi, CY, Kim, YH, Kwon, HJ, Kim, Y

J. Biol. Chem. 1999
11266540 All Tcf HMG box transcription factors interact with Groucho-related co-repressors

Brantjes, H, Roose, J, van De Wetering, M, Clevers, HC

Nucleic Acids Res. 2001
10485845 A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development

Chen, G, Fernandez, J, Mische, S, Courey, AJ

Genes Dev. 1999
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