Reactome: A Curated Pathway Database

USP8 deubiquitinates FZD to potentiate WNT signaling

Stable Identifier
R-HSA-4641236
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

USP8 is a deubiquitinase that enhances WNT signaling by deubiquitinating the FZD receptor and promoting its recycling to the cell surface (Mukai et al, 2010).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
thiol-dependent ubiquitin-specific protease activity of USP8 [cytosol] USP8 [cytosol] thiol-dependent ubiquitin-specific protease activity (0004843)
Orthologous Events