Reactome: A Curated Pathway Database

ZNRF3 autoubiquitinates to promote its internalization

Stable Identifier
R-HSA-4641246
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Mutation of the RING domain of ZNRF3 abrogates membrane clearance of the ubiquitin ligase, suggesting that its internalization depends on auto-ubiquitination (Hao et al, 2012).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
ubiquitin protein ligase activity of RSPO:LGR:ZNRF3,RNF43 [plasma membrane] RSPO:LGR:ZNRF3,RNF43 [plasma membrane] ubiquitin protein ligase activity (0061630)
Orthologous Events