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ZNRF3 autoubiquitinates to promote its internalization

Stable Identifier
R-HSA-4641246
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Mutation of the RING domain of ZNRF3 abrogates membrane clearance of the ubiquitin ligase, suggesting that its internalization depends on auto-ubiquitination (Hao et al, 2012).

Literature References
PubMed ID Title Journal Year
22575959 ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner Nature 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of RSPO:LGR:ZNRF3,RNF43 [plasma membrane]
Physical Entity
Activity
Orthologous Events