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ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

ZNFR3 and RNF43 are plasma membrane E3 RING domain ubiquitin ligases that have been shown to ubiquitinate FZD proteins to promote their downregulation (Hao et al, 2012). Inhibition of ZNRF3 or RNF43 increases the protein level of FZD and LRP6 at the plasma membrane, and stably expressed ZNRF3 can be co-immunoprecipitated with endogenous LRP6 and FZD6 (Hao et al, 2012; Jiang et al 2013). Turnover of the LRP6 and FZD receptors appears to be regulated by multiubiquitination and is abrogated upon treatment with lysosomal inhibitors (Mukai et al, 2010).

Participant Of
Orthologous Events