Degradation of AXIN

Stable Identifier
R-HSA-4641257
Type
Pathway
Species
Homo sapiens
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AXIN is present in low concentrations in the cell and is considered to be the limiting component of the beta-catenin destruction complex in Xenopus; this may not be the case in mammalian cells, however (Lee et al, 2003; Tan et al, 2012). Cellular levels of AXIN are regulated in part through ubiquitin-mediated turnover. E3 ligases SMURF2 and RNF146 have both been shown to play a role in promoting the degradation of AXIN by the 26S proteasome (Kim and Jho, 2010; Callow et al, 2011; Zhang et al, 2011).

Literature References
PubMed ID Title Journal Year
20858899 The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2)

Kim, S, Jho, EH

J. Biol. Chem. 2010
21478859 RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

Zhang, Y, Liu, S, Mickanin, C, Feng, Y, Charlat, O, Michaud, GA, Schirle, M, Shi, X, Hild, M, Bauer, A, Myer, VE, Finan, PM, Porter, JA, Huang, SM, Cong, F

Nat. Cell Biol. 2011
14551908 The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway

Lee, E, Salic, A, Kruger, R, Heinrich, R, Kirschner, MW

PLoS Biol 2003
21799911 Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling

Callow, MG, Tran, H, Phu, L, Lau, T, Lee, J, Sandoval, WN, Liu, PS, Bheddah, S, Tao, J, Lill, JR, Hongo, JA, Davis, D, Kirkpatrick, DS, Polakis, P, Costa, M

PLoS ONE 2011
22363759 Wnt signalling pathway parameters for mammalian cells

Tan, CW, Gardiner, BS, Hirokawa, Y, Layton, MJ, Smith, DW, Burgess, AW

PLoS ONE 2012
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