Degradation of DVL

Stable Identifier
R-HSA-4641258
Type
Pathway
Species
Homo sapiens
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DVL protein levels are regulated by both proteasomal and lysosomal degradation (reviewed in Gao and Chen, 2010). The E3 ligases HECF1, ITCH and KLHL12:CUL3 have all been shown to contribute to the polyubiquitination and subsequent degradation of DVL (Angers et al, 2006; Miyazaki et al, 2004; Wei et al, 2012). DVL stability is also regulated by its interaction with DACT1, which promotes degradation of DVL in the lysosome (Cheyette et al, 2002; Zhang et al, 2006).

Literature References
PubMed ID Title Journal Year
14684739 NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1

Miyazaki, K, Fujita, T, Ozaki, T, Kato, C, Kurose, Y, Sakamoto, M, Kato, S, Goto, T, Itoyama, Y, Aoki, M, Nakagawara, A

J. Biol. Chem. 2004
16446366 Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation

Zhang, L, Gao, X, Wen, J, Ning, Y, Chen, YG

J. Biol. Chem. 2006
11970895 Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation

Cheyette, BN, Waxman, JS, Miller, JR, Takemaru, K, Sheldahl, LC, Khlebtsova, N, Fox, EP, Earnest, T, Moon, RT

Dev. Cell 2002
20006983 Dishevelled: The hub of Wnt signaling

Gao, C, Chen, YG

Cell. Signal. 2010
22826439 The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein

Wei, W, Li, M, Wang, J, Nie, F, Li, L

Mol. Cell. Biol. 2012
16547521 The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation

Angers, S, Thorpe, CJ, Biechele, TL, Goldenberg, SJ, Zheng, N, Maccoss, MJ, Moon, RT

Nat Cell Biol 2006
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