Reactome | Degradation of DVL

Degradation of DVL

Stable Identifier

R-HSA-4641258

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

DVL protein levels are regulated by both proteasomal and lysosomal degradation (reviewed in Gao and Chen, 2010). The E3 ligases HECF1, ITCH and KLHL12:CUL3 have all been shown to contribute to the polyubiquitination and subsequent degradation of DVL (Angers et al, 2006; Miyazaki et al, 2004; Wei et al, 2012). DVL stability is also regulated by its interaction with DACT1, which promotes degradation of DVL in the lysosome (Cheyette et al, 2002; Zhang et al, 2006).

Literature References

PubMed ID	Title	Journal	Year
16446366	Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation Chen, YG, Ning, Y, Zhang, L, Wen, J, Gao, X	J. Biol. Chem.	2006
14684739	NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1 Miyazaki, K, Aoki, M, Itoyama, Y, Ozaki, T, Goto, T, Kurose, Y, Fujita, T, Kato, S, Kato, C, Nakagawara, A, Sakamoto, M	J. Biol. Chem.	2004
11970895	Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation Waxman, JS, Fox, EP, Khlebtsova, N, Sheldahl, LC, Cheyette, BN, Takemaru, K, Miller, JR, Moon, RT, Earnest, T	Dev. Cell	2002
20006983	Dishevelled: The hub of Wnt signaling Chen, YG, Gao, C	Cell. Signal.	2010
22826439	The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein Li, L, Nie, F, Wang, J, Li, M, Wei, W	Mol. Cell. Biol.	2012
16547521	The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation Maccoss, MJ, Biechele, TL, Thorpe, CJ, Zheng, N, Angers, S, Goldenberg, SJ, Moon, RT	Nat Cell Biol	2006