Reactome | SUMO1-K-TOP2B [nucleoplasm]

SUMO1-K-TOP2B [nucleoplasm]

Stable Identifier

R-HSA-4641297

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA topoisomerase 2-beta ecNumber5.99.1.3/ecNumber, TOP2B_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of DNA replication proteins (Homo sapiens)
        
        SUMOylation of TOP2B with SUMO1 (Homo sapiens)
        
        SUMO1:TOP2B [nucleoplasm] (Homo sapiens)
        
        SUMO1-K-TOP2B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q02880 TOP2B

Gene Names

TOP2B

Chain

initiator methionine:1, chain:2-1626

Reference Genes

BioGPS Gene:7155 TOP2B

COSMIC (genes):TOP2B TOP2B

CTD Gene:7155 TOP2B

dbSNP Gene:7155 TOP2B

ENSEMBL:ENSG00000077097 TOP2B

HGNC:11990 TOP2B

KEGG Gene (Homo sapiens):7155 TOP2B

Monarch:7155 TOP2B

NCBI Gene:7155 TOP2B

OMIM:126431 TOP2B

UCSC:Q02880 TOP2B

Reference Transcript

Other Identifiers

0003870270

11716247_s_at

11749531_x_at

11757323_x_at

1581_s_at

16951601

211987_at

2666475

2666477

2666479

2666480

2666481

2666482

2666486

2666488

2666493

2666495

2666496

2666497

2666498

2666499

2666500

2666501

2666502

2666503

2666504

2666505

2666506

2666507

2666509

2666510

2666511

2666512

2666516

2666517

2666519

2666521

2666522

2666524

2666525

2666526

2666527

2666528

2666529

2666530

2666531

2666532

2666533

2666534

2666537

2666538

2666540

2666541

2666548

2666549

36571_at

7155

8085815

A_23_P121095

GE59941

GO:0000003

GO:0000166

GO:0000278

GO:0000712

GO:0000792

GO:0000819

GO:0000902

GO:0001764

GO:0003674

GO:0003677

GO:0003682

GO:0003916

GO:0003918

GO:0005080

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006259

GO:0006265

GO:0007049

GO:0007059

GO:0007409

GO:0008022

GO:0008150

GO:0016853

GO:0016887

GO:0019035

GO:0019899

GO:0030154

GO:0030900

GO:0032991

GO:0034641

GO:0040011

GO:0042826

GO:0043167

GO:0043226

GO:0044403

GO:0044774

GO:0045870

GO:0046872

GO:0046982

GO:0048856

GO:0048870

GO:0051276

GO:1990904

Hs.75248.0.S1_3p_at

ILMN_1777663

M27504_s_at

PH_hs_0023447

TC03001247.hg

Z15115_at

Participant Of

hasComponent

SUMO1:TOP2B [nucleoplasm]

Other forms of this molecule

TOP2B [nucleoplasm]

Inferred To

cin-4 [nucleoplasm] (Caenorhabditis elegans)

top2b [nucleoplasm] (Danio rerio)

top2b [nucleoplasm] (Xenopus tropicalis)

Homologues of SUMO1-K-TOP2B [nucleoplasm] (Caenorhabditis elegans)

Homologues of SUMO1-K-TOP2B [nucleoplasm] (Dictyostelium discoideum)

top2 [nucleoplasm] (Dictyostelium discoideum)

top2 [nucleoplasm] (Schizosaccharomyces pombe)

Top2b [nucleoplasm] (Mus musculus)

top2mt [nucleoplasm] (Dictyostelium discoideum)

top-2 [nucleoplasm] (Caenorhabditis elegans)

SUMO1-K-TOP2B [nucleoplasm] (Caenorhabditis elegans)

SUMO1-K-TOP2B [nucleoplasm] (Plasmodium falciparum)

TOP2B [nucleoplasm] (Canis familiaris)

TOP2B [nucleoplasm] (Sus scrofa)

TOP2 [nucleoplasm] (Saccharomyces cerevisiae)

Modified Residues

Name

Inter-chain Crosslink via sumoylated lysine at unknown and 97

Modification

glycyl group

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_001317629.1, NP_001059.2

OpenTargets

ENSG00000077097

IntEnz

5.6.2.2

ZINC - Substances

TOP2B_HUMAN

GeneCards

Q02880

HPA

ENSG00000077097-TOP2B

ZINC target

Q02880

Ensembl

ENST00000264331, ENSG00000077097, ENSP00000264331, ENSP00000396704, ENST00000435706

PRO

Q02880

Orphanet

28587

HMDB Protein

HMDBP02207

PDB

5ZRF, 4J3N, 4G0U, 4G0W, 5GWI, 5ZEN, 3QX3, 5ZAD, 4G0V, 5ZQF, 5GWJ

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22415 USF1	1	USF1 [nucleoplasm] (R-HSA-9023562)	0.558	3
UniProt:P46531 NOTCH1	60	NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205) p-NICD1 P2514Rfs4 [nucleoplasm] (R-HSA-2159809) p-NICD1 P2474Afs4 [nucleoplasm] (R-HSA-2902204) NOTCH1 L1574P Extracellular Fragment [extracellular region] (R-HSA-1485582) NOTCH1 L1600P Extracellular Fragment [extracellular region] (R-HSA-2681764) NEXT1 P2474Afs4 [plasma membrane] (R-HSA-2902194) NEXT1 Q2395 [plasma membrane] (R-HSA-2902192) NEXT1 Q2440* [plasma membrane] (R-HSA-2902196) NEXT1 P2514Rfs4 [plasma membrane] (R-HSA-2768989) NICD1 Q2395 [cytosol] (R-HSA-2902195) NICD1 P2514Rfs4 [cytosol] (R-HSA-2768996) NICD1 P2474Afs4 [cytosol] (R-HSA-2902193) NICD1 Q2440* [cytosol] (R-HSA-2902191) NICD1 P2514Rfs4 [nucleoplasm] (R-HSA-2769013) NICD1 P2474Afs4 [nucleoplasm] (R-HSA-2902208) NICD1 Q2395* [nucleoplasm] (R-HSA-2902201) NICD1 Q2440* [nucleoplasm] (R-HSA-2902200) NOTCH1 P2514Rfs4 Transmembrane Fragment [plasma membrane] (R-HSA-2768982) NOTCH1 Q2395 Transmembrane Fragment [plasma membrane] (R-HSA-1485596) NOTCH1 Q2440* Transmembrane Fragment [plasma membrane] (R-HSA-1485602) NOTCH1 P2474Afs*4 Transmembrane Fragment [plasma membrane] (R-HSA-2894873) NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment [extracellular region] (R-HSA-2220929) p-NICD1 [nucleoplasm] (R-HSA-1604444) Glc,GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911426) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911415) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911503) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [Golgi membrane] (R-HSA-1911511) Pre-NOTCH1 [endoplasmic reticulum membrane] (R-HSA-157024) 17xFucT-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] (R-HSA-1467396) 19xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] (R-HSA-1467425) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [Golgi membrane] (R-HSA-1472872) NOTCH1(1665-2555) [Golgi membrane] (R-HSA-157092) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) [Golgi membrane] (R-HSA-1983679) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [plasma membrane] (R-HSA-1911512) NOTCH1(1665-2555) [plasma membrane] (R-HSA-157239) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) [extracellular region] (R-HSA-1983670) NOTCH1(1665-1720) [extracellular region] (R-HSA-157654) NOTCH1(1721-1753) [plasma membrane] (R-HSA-157656) NEXT1 [plasma membrane] (R-HSA-157200) NICD1 [cytosol] (R-HSA-157634) NICD1 [nucleoplasm] (R-HSA-157939)	0.462	2
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [cytosol] (R-HSA-9020974) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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