SUMOylation of TOP2A with SUMO1

Stable Identifier
R-HSA-4641342
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TOP2A is SUMOylated with SUMO1 (Mao et al. 2000, Dawlaty et al. 2008, Matafora et al. 2009, Impens et al. 2014). SUMOylation is observed in response to TOP2A-mediated DNA damage induced by teniposide.

Literature References
PubMed ID Title Journal Year
19596686 Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition

Matafora, V, D'Amato, A, Mori, S, Blasi, F, Bachi, A

Mol. Cell Proteomics 2009
18394993 Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha

Dawlaty, MM, Malureanu, L, Jeganathan, KB, Kao, E, Sustmann, C, Tahk, S, Shuai, K, Grosschedl, R, van Deursen, JM

Cell 2008
10862613 SUMO-1 conjugation to human DNA topoisomerase II isozymes

Mao, Y, Desai, SD, Liu, LF

J. Biol. Chem. 2000
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Radoshevich, L, Cossart, P, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created