SUMOylation of TOP2B with SUMO1

Stable Identifier
R-HSA-4641345
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TOP2B is SUMOylated with SUMO1 (Mao et al. 2000, Isik et al. 2003). SUMOylation is observed in response to topoisomerase-mediated DNA damage induced by teniposide.

Literature References
PubMed ID Title Journal Year
12832072 The SUMO pathway is required for selective degradation of DNA topoisomerase IIbeta induced by a catalytic inhibitor ICRF-193(1)

Isik, S, Sano, K, Tsutsui, K, Seki, M, Enomoto, T, Saitoh, H, Tsutsui, K

FEBS Lett. 2003
10862613 SUMO-1 conjugation to human DNA topoisomerase II isozymes

Mao, Y, Desai, SD, Liu, LF

J. Biol. Chem. 2000
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created