PIAS4 SUMOylates TOP2A with SUMO2,3

Stable Identifier
R-HSA-4641350
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PIAS4 SUMOylates TOP2A with SUMO2,3 (Diaz-Martinez et al. 2006, Agostinho et al. 2008, Impens et al. 2014, Tammsalu et al. 2014). SUMOylation is observed in interphase and mitosis in response to inhibitors of topoisomerase. SUMOylated TOP2A is localized to centromeres during mitosis.

Literature References
PubMed ID Title Journal Year
24782567 Proteome-wide identification of SUMO2 modification sites

Tammsalu, T, Matic, I, Jaffray, EG, Ibrahim, AF, Tatham, MH, Hay, RT

Sci Signal 2014
18381449 Conjugation of human topoisomerase 2 alpha with small ubiquitin-like modifiers 2/3 in response to topoisomerase inhibitors: cell cycle stage and chromosome domain specificity

Agostinho, M, Santos, V, Ferreira, F, Costa, R, Cardoso, J, Pinheiro, I, Rino, J, Jaffray, E, Hay, RT, Ferreira, J

Cancer Res. 2008
17183683 PIASgamma is required for faithful chromosome segregation in human cells

Díaz-Martínez, LA, Giménez-Abián, JF, Azuma, Y, Guacci, V, Giménez-Martín, G, Lanier, LM, Clarke, DJ

PLoS ONE 2006
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Radoshevich, L, Cossart, P, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
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Event Information
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Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS4 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created