SUMOylation of TOP1 with SUMO1

Stable Identifier
R-HSA-4641362
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TOP1 is SUMOylated at lysine-117 with SUMO1 (Mao et al. 2000, Mo et al. 2002, Rallabhandi et al. 2002, Impens et al. 2014). SUMOylation is observed in response to the topoisomerase inhibitor camptothecin and causes nucleolar delocalization of TOP1.

Literature References
PubMed ID Title Journal Year
12149243 Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin

Rallabhandi, P, Hashimoto, K, Mo, YY, Beck, WT, Moitra, PK, D'Arpa, P

J. Biol. Chem. 2002
10759568 SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage

Mao, Y, Sun, M, Desai, SD, Liu, LF

Proc. Natl. Acad. Sci. U.S.A. 2000
11709553 Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the protein

Mo, YY, Yu, Y, Shen, Z, Beck, WT

J. Biol. Chem. 2002
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Radoshevich, L, Cossart, P, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created