Transcriptional activation of CDKN1A by TP53 is inhibited by EP400

Stable Identifier
R-HSA-4647613
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CDKN1A (p21) is transcriptionally activated by TP53 (p53) after DNA damage (el-Deiry et al. 1993). EP400 (p400) binds to a CDKN1A promoter region that overlaps with the distal TP53-binding site and can co-localize with TP53 on CDKN1A promoter. The presence of EP400 results in the downregulation of CDKN1A transcription without affecting the phosphorylation of TP53 on serine S15 (Chan et al. 2005).

Literature References
PubMed ID Title Journal Year
8242752 WAF1, a potential mediator of p53 tumor suppression.

el-Deiry, WS, Tokino, T, Velculescu, VE, Levy, DB, Parsons, R, Trent, JM, Lin, D, Mercer, WE, Kinzler, KW, Vogelstein, B

Cell 1993
15655109 The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway

Chan, HM, Narita, M, Lowe, SW, Livingston, DM

Genes Dev. 2005
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