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BIRC5 [nucleoplasm]
Stable Identifier
R-HSA-4655344
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Survivin, Baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor survivin, Apoptosis inhibitor 4
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
TP53 inhibits BIRC5 expression (Homo sapiens)
BIRC5 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated nuclear proteins (Homo sapiens)
STAT3-upregulated nuclear proteins [nucleoplasm] (Homo sapiens)
BIRC5 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA replication proteins (Homo sapiens)
RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Homo sapiens)
Chromosome passenger complex [nucleoplasm] (Homo sapiens)
BIRC5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15392 BIRC5
Gene Names
BIRC5, API4, IAP4
Chain
chain:1-142
Reference Genes
BioGPS Gene:332 BIRC5
COSMIC (genes):BIRC5 BIRC5
CTD Gene:332 BIRC5
dbSNP Gene:332 BIRC5
ENSEMBL:ENSG00000089685 BIRC5
HGNC:593 BIRC5
KEGG Gene (Homo sapiens):332 BIRC5
Monarch:332 BIRC5
NCBI Gene:332 BIRC5
OMIM:603352 BIRC5
UCSC:O15392 BIRC5
Reference Transcript
RefSeq:NM_001012270.1 BIRC5
RefSeq:NM_001168.2 BIRC5
RefSeq:NM_001012271.1 BIRC5
Other Identifiers
0002120152
11733864_a_at
11739602_a_at
11739603_x_at
11739653_a_at
11747720_a_at
11754109_s_at
11754110_x_at
11759736_a_at
11759737_x_at
11760008_at
11763580_x_at
16838359
202094_at
202095_s_at
210334_x_at
332
3736291
3736292
3736293
3736294
3736295
3736296
3736299
3736301
3736303
3736304
3736305
3736306
3736307
3736308
3736309
3736310
3736311
3736312
3736314
3736316
40532_at
8010260
A_14_P100099
A_23_P118815
GE59394
GO:0000228
GO:0000278
GO:0000775
GO:0000776
GO:0000777
GO:0003674
GO:0004869
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005819
GO:0005829
GO:0005856
GO:0005874
GO:0005876
GO:0006464
GO:0006468
GO:0006915
GO:0007010
GO:0007049
GO:0007059
GO:0007165
GO:0007605
GO:0008017
GO:0008092
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008536
GO:0009058
GO:0010466
GO:0019221
GO:0019899
GO:0022607
GO:0030234
GO:0030414
GO:0030496
GO:0031503
GO:0032133
GO:0032991
GO:0034641
GO:0042802
GO:0042981
GO:0043027
GO:0043066
GO:0043154
GO:0043167
GO:0043226
GO:0045892
GO:0046872
GO:0050877
GO:0051087
GO:0051301
GO:0090307
GO:0140014
Hs.1578.0.S2_3p_at
ILMN_1710082
ILMN_1803124
ILMN_2349459
PH_hs_0000213
PH_hs_0040283
g4502144_3p_a_at
g7416052_3p_a_at
g7416052_3p_x_at
Participant Of
hasComponent
Chromosome passenger complex [nucleoplasm]
hasMember
STAT3-upregulated nuclear proteins [nucleoplasm]
output
TP53 inhibits BIRC5 expression
Other forms of this molecule
ub-BIRC5 [cytosol]
BIRC5 [cytosol]
Inferred To
Birc5 [nucleoplasm] (Mus musculus)
Ghost homologue of BIRC5 [nucleoplasm] (Canis familiaris)
Ghost homologue of BIRC5 [nucleoplasm] (Drosophila melanogaster)
Ghost homologue of BIRC5 [nucleoplasm] (Rattus norvegicus)
Ghost homologue of BIRC5 [nucleoplasm] (Sus scrofa)
birc5.2 [nucleoplasm] (Xenopus tropicalis)
birc5a [nucleoplasm] (Danio rerio)
BIRC5 [nucleoplasm] (Bos taurus)
Cross References
RefSeq
NP_001012271.1
,
NP_001012270.1
,
NP_001159.2
OpenTargets
ENSG00000089685
HPA
ENSG00000089685-BIRC5
ZINC - Substances
BIRC5_HUMAN
GeneCards
O15392
ZINC target
O15392
Ensembl
ENSG00000089685
,
ENST00000592734
,
ENSP00000466617
,
ENSP00000364086
,
ENST00000590449
,
ENSP00000467336
,
ENST00000590925
,
ENST00000374948
,
ENSP00000465868
PRO
O15392
ZINC - Predictions - Purchasable
BIRC5_HUMAN
Orphanet
24370
PDB
4A0N
,
3UIG
,
3UEH
,
3UIH
,
6SHO
,
3UEI
,
2RAX
,
1XOX
,
4A0I
,
3UEF
,
2RAW
,
2QFA
,
6YIH
,
1F3H
,
3UEG
,
4A0J
,
6YIF
,
3UEE
,
3UED
,
3UIJ
,
6YIE
,
3UIK
,
3UII
,
3UEC
,
1E31
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96GD4 AURKB
3
AURKB [nucleoplasm]
(R-HSA-4655360)
SUMO2,3-K202-AURKB [cytosol]
(R-HSA-4655414)
AURKB [cytosol]
(R-HSA-174231)
0.954
13
UniProt:Q53HL2 CDCA8
3
CDCA8 [nucleoplasm]
(R-HSA-4655357)
SUMO2,3-CDCA8 [cytosol]
(R-HSA-4655328)
CDCA8 [cytosol]
(R-HSA-375288)
0.941
19
UniProt:Q9NQS7 INCENP
2
INCENP [cytosol]
(R-HSA-375311)
INCENP [nucleoplasm]
(R-HSA-4655393)
0.891
10
IntAct:EBI-15634422 H3K9-2
0.76
8
UniProt:Q9UQB9 AURKC
0.739
10
ChEBI:78766 LLP-3
0.65
4
UniProt:P62826 RAN
2
RAN [cytosol]
(R-HSA-165540)
RAN [nucleoplasm]
(R-HSA-165528)
0.645
7
IntAct:EBI-15949926 HSGO1
0.618
3
UniProt:O15392 BIRC5
3
BIRC5 [nucleoplasm]
(R-HSA-4655344)
ub-BIRC5 [cytosol]
(R-HSA-8955933)
BIRC5 [cytosol]
(R-HSA-50851)
0.609
2
UniProt:P55211 CASP9
6
CASP9(1-416) [cytosol]
(R-HSA-57033)
p-T125-CASP9(1-416) [cytosol]
(R-HSA-9627087)
CASP9(331-416) [cytosol]
(R-HSA-141639)
CASP9(?-315) [cytosol]
(R-HSA-141638)
CASP9(1-416) [cytosol]
(R-HSA-114257)
p-S196-CASP9(1-416) [cytosol]
(R-HSA-198636)
0.589
2
IntAct:EBI-15963608 SMACN
0.558
2
UniProt:Q86XJ1 GA2L3
0.558
4
UniProt:P37840 SNCA
4
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [cytosol]
(R-HSA-5658500)
Ub-SNCA [cytosol]
(R-HSA-5660754)
0.556
3
UniProt:P05067-2 APP
0.556
3
UniProt:Q7Z412 PEX26
2
PEX26 [peroxisomal membrane]
(R-HSA-9033092)
PEX26 [cytosol]
(R-HSA-9603779)
0.556
3
UniProt:A0A0C4DGV4 A0A0C4DGV4
0.556
3
UniProt:Q8TB36 GDAP1
2
GDAP1 [cytosol]
(R-HSA-9603796)
GDAP1 [peroxisomal membrane]
(R-HSA-9603788)
0.556
3
UniProt:Q15834 CC85B
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
15
UniProt:Q9BXM7 PINK1
4
PINK1 [mitochondrial intermembrane space]
(R-HSA-5205671)
PINK1 [mitochondrial outer membrane]
(R-HSA-5205653)
PINK1 [cytosol]
(R-HSA-5205637)
PINK1(111-581) [mitochondrial intermembrane space]
(R-HSA-5205628)
0.556
3
UniProt:P09936 UCHL1
1
UCHL1 [cytosol]
(R-HSA-5660679)
0.556
3
UniProt:Q14203-5 DCTN1
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
IntAct:EBI-25865403 EHD27213144
0.556
3
UniProt:Q92870-2 Q928702
0.556
3
UniProt:Q13148 TADBP
0.556
6
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q96CV9 OPTN
4
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
0.556
3
UniProt:O14965 AURKA
6
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
AURKA [nucleoplasm]
(R-HSA-4655443)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [cytosol]
(R-HSA-2574832)
0.525
2
UniProt:Q14457 BECN1
3
BECN1 [cytosol]
(R-HSA-1632841)
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
0.524
3
UniProt:O14980 XPO1
2
XPO1 [nucleoplasm]
(R-HSA-165529)
XPO1 [cytosol]
(R-HSA-165539)
0.524
2
UniProt:P06493 CDK1
10
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
CDK1 [cytosol]
(R-HSA-170075)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
0.463
6
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