Reactome | BIRC5 [nucleoplasm]

BIRC5 [nucleoplasm]

Stable Identifier

R-HSA-4655344

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Survivin, Baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor survivin, Apoptosis inhibitor 4

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        TP53 inhibits BIRC5 expression (Homo sapiens)
        
        BIRC5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15392 BIRC5

Gene Names

BIRC5, API4, IAP4

Chain

chain:1-142

Reference Genes

BioGPS Gene:332 BIRC5

COSMIC (genes):BIRC5 BIRC5

CTD Gene:332 BIRC5

dbSNP Gene:332 BIRC5

ENSEMBL:ENSG00000089685 BIRC5

HGNC:593 BIRC5

KEGG Gene (Homo sapiens):332 BIRC5

Monarch:332 BIRC5

NCBI Gene:332 BIRC5

OMIM:603352 BIRC5

UCSC:O15392 BIRC5

Reference Transcript

Other Identifiers

0002120152

11733864_a_at

11739602_a_at

11739603_x_at

11739653_a_at

11747720_a_at

11754109_s_at

11754110_x_at

11759736_a_at

11759737_x_at

11760008_at

11763580_x_at

16838359

202094_at

202095_s_at

210334_x_at

332

3736291

3736292

3736293

3736294

3736295

3736296

3736299

3736301

3736303

3736304

3736305

3736306

3736307

3736308

3736309

3736310

3736311

3736312

3736314

3736316

40532_at

8010260

A_14_P100099

A_23_P118815

GE59394

GO:0000228

GO:0000278

GO:0000775

GO:0000776

GO:0000777

GO:0003674

GO:0004869

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005819

GO:0005829

GO:0005856

GO:0005874

GO:0005876

GO:0006464

GO:0006468

GO:0006915

GO:0007010

GO:0007049

GO:0007059

GO:0007165

GO:0007605

GO:0008017

GO:0008092

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008536

GO:0009058

GO:0010466

GO:0019221

GO:0019899

GO:0022607

GO:0030234

GO:0030414

GO:0030496

GO:0031503

GO:0032133

GO:0032991

GO:0034641

GO:0042802

GO:0042981

GO:0043027

GO:0043066

GO:0043154

GO:0043167

GO:0043226

GO:0045892

GO:0046872

GO:0050877

GO:0051087

GO:0051301

GO:0090307

GO:0140014

Hs.1578.0.S2_3p_at

ILMN_1710082

ILMN_1803124

ILMN_2349459

PH_hs_0000213

PH_hs_0040283

g4502144_3p_a_at

g7416052_3p_a_at

g7416052_3p_x_at

Participant Of

hasComponent

Chromosome passenger complex [nucleoplasm]

hasMember

STAT3-upregulated nuclear proteins [nucleoplasm]

output

TP53 inhibits BIRC5 expression

Other forms of this molecule

ub-BIRC5 [cytosol]

BIRC5 [cytosol]

Inferred To

Birc5 [nucleoplasm] (Mus musculus)

Ghost homologue of BIRC5 [nucleoplasm] (Canis familiaris)

Ghost homologue of BIRC5 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of BIRC5 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of BIRC5 [nucleoplasm] (Sus scrofa)

birc5.2 [nucleoplasm] (Xenopus tropicalis)

birc5a [nucleoplasm] (Danio rerio)

BIRC5 [nucleoplasm] (Bos taurus)

Cross References

RefSeq

NP_001012271.1, NP_001159.2, NP_001012270.1

OpenTargets

ENSG00000089685

HPA

ENSG00000089685-BIRC5

ZINC - Substances

BIRC5_HUMAN

GeneCards

O15392

ZINC target

O15392

Ensembl

ENSP00000466617, ENSP00000467336, ENST00000374948, ENSP00000465868, ENSG00000089685, ENST00000592734, ENSP00000364086, ENST00000590925, ENST00000590449

PRO

O15392

Orphanet

24370

ZINC - Predictions - Purchasable

BIRC5_HUMAN

PDB

3UII, 1XOX, 2RAX, 3UIJ, 2RAW, 3UIK, 3UEE, 1F3H, 6YIE, 2QFA, 3UEF, 6YIF, 4A0I, 4A0J, 3UEG, 6YIH, 3UEH, 6SHO, 1E31, 3UIG, 3UEI, 3UED, 4A0N, 3UEC, 3UIH

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96GD4 AURKB	3	AURKB [nucleoplasm] (R-HSA-4655360) SUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [cytosol] (R-HSA-174231)	0.954	13
UniProt:Q53HL2 CDCA8	3	CDCA8 [nucleoplasm] (R-HSA-4655357) SUMO2,3-CDCA8 [cytosol] (R-HSA-4655328) CDCA8 [cytosol] (R-HSA-375288)	0.941	19
UniProt:Q9NQS7 INCENP	2	INCENP [cytosol] (R-HSA-375311) INCENP [nucleoplasm] (R-HSA-4655393)	0.891	10
IntAct:EBI-15634422 H3K9-2			0.76	8
UniProt:Q9UQB9 AURKC			0.739	10
ChEBI:78766 LLP-3			0.65	4
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.645	7
IntAct:EBI-15949926 HSGO1			0.618	3
UniProt:O15392 BIRC5	3	BIRC5 [nucleoplasm] (R-HSA-4655344) ub-BIRC5 [cytosol] (R-HSA-8955933) BIRC5 [cytosol] (R-HSA-50851)	0.609	2
UniProt:P55211 CASP9	6	CASP9(1-416) [cytosol] (R-HSA-57033) p-T125-CASP9(1-416) [cytosol] (R-HSA-9627087) CASP9(331-416) [cytosol] (R-HSA-141639) CASP9(?-315) [cytosol] (R-HSA-141638) CASP9(1-416) [cytosol] (R-HSA-114257) p-S196-CASP9(1-416) [cytosol] (R-HSA-198636)	0.589	2
UniProt:Q86XJ1 GA2L3			0.558	4
IntAct:EBI-15963608 SMACN			0.558	2
UniProt:A0A0C4DGV4 A0A0C4DGV4			0.556	3
UniProt:Q15834 CC85B			0.556	3
UniProt:O14965 AURKA	6	AURKA [nucleoplasm] (R-HSA-4655443) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832)	0.525	2
UniProt:O14980 XPO1	2	XPO1 [nucleoplasm] (R-HSA-165529) XPO1 [cytosol] (R-HSA-165539)	0.524	2
UniProt:Q14457 BECN1	3	BECN1 [cytosol] (R-HSA-1632841) K63polyUb-BECN1 [cytosol] (R-HSA-6782989) p-S15-BECN1 [cytosol] (R-HSA-5682391)	0.524	3
UniProt:P06493 CDK1	10	CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) CDK1 [cytosol] (R-HSA-170075) p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078)	0.463	6