Reactome | BIRC5 [nucleoplasm]

BIRC5 [nucleoplasm]

Stable Identifier

R-HSA-4655344

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Survivin, Baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor survivin, Apoptosis inhibitor 4

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        TP53 inhibits BIRC5 expression (Homo sapiens)
        
        BIRC5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15392 BIRC5

Gene Names

BIRC5, API4, IAP4

Chain

chain:1-142

Reference Genes

BioGPS Gene:332 BIRC5

COSMIC (genes):BIRC5 BIRC5

CTD Gene:332 BIRC5

dbSNP Gene:332 BIRC5

ENSEMBL:ENSG00000089685.15 BIRC5

HGNC:593 BIRC5

KEGG Gene (Homo sapiens):332 BIRC5

Monarch:332 BIRC5

NCBI Gene:332 BIRC5

OMIM:603352 BIRC5

UCSC:O15392 BIRC5

Reference Transcript

Other Identifiers

0002120152

11733864_a_at

11739602_a_at

11739603_x_at

11739653_a_at

11747720_a_at

11754109_s_at

11754110_x_at

11759736_a_at

11759737_x_at

11760008_at

11763580_x_at

16838359

202094_PM_at

202094_at

202095_PM_s_at

202095_s_at

210334_PM_x_at

210334_x_at

332

3736291

3736292

3736293

3736294

3736295

3736296

3736299

3736301

3736303

3736304

3736305

3736306

3736307

3736308

3736309

3736310

3736311

3736312

3736314

3736316

40532_at

8010260

A_14_P100099

A_23_P118815

GE59394

GO:0000228

GO:0000278

GO:0000281

GO:0000775

GO:0000776

GO:0000910

GO:0001934

GO:0003674

GO:0004869

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005819

GO:0005829

GO:0005856

GO:0005874

GO:0005876

GO:0006351

GO:0006355

GO:0006468

GO:0006915

GO:0007010

GO:0007049

GO:0007052

GO:0007059

GO:0007605

GO:0008017

GO:0008092

GO:0008150

GO:0008284

GO:0010466

GO:0010951

GO:0012501

GO:0015630

GO:0019899

GO:0023052

GO:0030234

GO:0030414

GO:0030496

GO:0031267

GO:0031503

GO:0032133

GO:0032268

GO:0032991

GO:0036211

GO:0042802

GO:0042981

GO:0043027

GO:0043066

GO:0043154

GO:0043167

GO:0043226

GO:0045892

GO:0046872

GO:0050877

GO:0051087

GO:0051256

GO:0051301

GO:0051726

GO:0052548

GO:0090267

GO:0140014

GO:1901970

GO:1902425

GO:1903490

GO:1990713

HMNXSV003017704

Hs.1578.0.S2_3p_at

ILMN_1710082

ILMN_1803124

ILMN_2349459

PH_hs_0000213

PH_hs_0040283

g4502144_3p_a_at

g7416052_3p_a_at

g7416052_3p_x_at

Participates

as a component of

Chromosome passenger complex [nucleoplasm] (Homo sapiens)

as a member of

STAT3-upregulated nuclear proteins [nucleoplasm] (Homo sapiens)

as an output of

TP53 inhibits BIRC5 expression (Homo sapiens)

Other forms of this molecule

ub-BIRC5 [cytosol]

BIRC5 [cytosol]

Inferred To

Ghost homologue of BIRC5 [nucleoplasm] (Danio rerio)

Ghost homologue of BIRC5 [nucleoplasm] (Mus musculus)

Ghost homologue of BIRC5 [nucleoplasm] (Xenopus tropicalis)

Det [nucleoplasm] (Drosophila melanogaster)

BIRC5 [nucleoplasm] (Bos taurus)

BIRC5 [nucleoplasm] (Canis familiaris)

BIRC5 [nucleoplasm] (Gallus gallus)

BIRC5 [nucleoplasm] (Rattus norvegicus)

BIRC5 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001012270.1, NP_001159.2, NP_001012271.1

Guide to Pharmacology - Targets

2795

OpenTargets

ENSG00000089685

ZINC - Substances

BIRC5_HUMAN

ZINC target

O15392

PRO

O15392

PDB

4A0I, 3UEF, 1E31, 3UIK, 6YIF, 3UEE, 3UIJ, 6YIE, 3UED, 3UII, 3UEC, 2RAX, 3UIH, 7LBQ, 1XOX, 7LBP, 3UIG, 2RAW, 3UEI, 6SHO, 7LBO, 3UEH, 1F3H, 4A0N, 2QFA, 4A0J, 6YIH, 3UEG, 7LBK

HPA

ENSG00000089685-BIRC5

GeneCards

O15392

Ensembl

ENSP00000364086, ENST00000590925, ENST00000590449, ENSP00000467336, ENST00000592734, ENSG00000089685, ENSP00000465868, ENST00000374948, ENSP00000466617

Pharos - Targets

O15392

ZINC - Predictions - Purchasable

BIRC5_HUMAN

Orphanet

24370

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96GD4 AURKB	3	polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [nucleoplasm] (R-HSA-4655360) AURKB [cytosol] (R-HSA-174231)	0.952	13
UniProt:Q53HL2 CDCA8	3	polySUMO2,3-CDCA8 [cytosol] (R-HSA-4655328) CDCA8 [nucleoplasm] (R-HSA-4655357) CDCA8 [cytosol] (R-HSA-375288)	0.941	19
UniProt:Q9NQS7 INCENP	2	INCENP [nucleoplasm] (R-HSA-4655393) INCENP [cytosol] (R-HSA-375311)	0.888	10
IntAct:EBI-15634422 H3K9-2			0.76	8
UniProt:Q9UQB9 AURKC			0.739	10
ChEBI:78766 LLP-3			0.642	4
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.635	7
IntAct:EBI-15949926 HSGO1			0.618	3
UniProt:O15392 BIRC5	3	ub-BIRC5 [cytosol] (R-HSA-8955933) BIRC5 [nucleoplasm] (R-HSA-4655344) BIRC5 [cytosol] (R-HSA-50851)	0.609	2
IntAct:EBI-15963608 SMACN			0.558	2
UniProt:Q86XJ1 GA2L3			0.558	4
UniProt:P37840 SNCA	4	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.556	3
UniProt:P05067-2 APP			0.556	3
UniProt:Q7Z412 PEX26	2	PEX26 [cytosol] (R-HSA-9603779) PEX26 [peroxisomal membrane] (R-HSA-9033092)	0.556	3
UniProt:A0A0C4DGV4 A0A0C4DGV4			0.556	3
UniProt:Q8TB36 GDAP1	2	GDAP1 [peroxisomal membrane] (R-HSA-9603788) GDAP1 [cytosol] (R-HSA-9603796)	0.556	3
UniProt:Q15834 CC85B			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.556	3
UniProt:Q14203-5 DCTN1			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q92870-2 Q928702			0.556	3
UniProt:Q13148 TADBP			0.556	6
UniProt:Q96CV9 OPTN	5	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907)	0.556	3
UniProt:Q9BXM7 PINK1	4	PINK1 [mitochondrial outer membrane] (R-HSA-5205653) PINK1 [mitochondrial intermembrane space] (R-HSA-5205671) PINK1 [cytosol] (R-HSA-5205637) PINK1(111-581) [mitochondrial intermembrane space] (R-HSA-5205628)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	15
UniProt:P55211 CASP9	5	p-S196-CASP9(1-416) [cytosol] (R-HSA-198636) p-T125-CASP9(1-416) [cytosol] (R-HSA-9627087) CASP9(331-416) [cytosol] (R-HSA-141639) CASP9(?-315) [cytosol] (R-HSA-141638) CASP9(1-416) [cytosol] (R-HSA-57033)	0.536	2
UniProt:O14965 AURKA	6	SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) AURKA [nucleoplasm] (R-HSA-4655443) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832)	0.525	2
UniProt:O14980 XPO1	2	XPO1 [nucleoplasm] (R-HSA-165529) XPO1 [cytosol] (R-HSA-165539)	0.524	2
UniProt:Q14457 BECN1	3	K63polyUb-BECN1 [cytosol] (R-HSA-6782989) p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841)	0.524	3
UniProt:P06493 CDK1	10	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.463	6

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