SUMOylation of AURKA with SUMO1

Stable Identifier
R-HSA-4655404
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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As inferred from mouse homologs, AURKA (Aurora-A) is SUMOylated at lysine-258 with SUMO1. AURKA, SUMO1, and UBE2I (UBC9) colocalize to centrisomes and the mitotic spindle. SUMOylation of AURKA is required for proper localization to the microtubules of the mitotic spindle therefore SUMOylated AURKA is assumed to be located on spindles in the cytosol during metphase.

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