SUMO2,3-K202-AURKB [cytosol]

Stable Identifier
R-HSA-4655414
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Aurora B
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
21554500 Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis

Ban, R, Nishida, T, Urano, T

Genes Cells 2011
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC

Nat. Struct. Mol. Biol. 2014
External Reference Information
External Reference
UniProt:Q96GD4 AURKB
Gene Names
AURKB, AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5
Chain
chain:1-344
Reference Genes
BioGPS Gene:9212 AURKB
COSMIC (genes):AURKB AURKB
CTD Gene:9212 AURKB
dbSNP Gene:9212 AURKB
ENSEMBL:ENSG00000178999 AURKB
HGNC:11390 AURKB
KEGG Gene (Homo sapiens):9212 AURKB
Monarch:9212 AURKB
NCBI Gene:9212 AURKB
OMIM:604970 AURKB
UCSC:Q96GD4 AURKB
Reference Transcript
Other Identifiers
0001780050
04150+2.7.11.1
04151+2.7.11.1
04714+2.7.11.1
04926+2.7.11.1
05163+2.7.11.1
05165+2.7.11.1
05170+2.7.11.1
11720203_a_at
16840902
209464_at
33266_at
3744271
3744272
3744273
3744274
3744275
3744276
3744278
3744279
3744281
3744282
3744283
3744284
3744290
3744291
3744292
3744293
3744294
37708
4AF3
5862
8012403
9212
A_23_P130182
AAB65786
AAC12709
AAC98891
AAH00442
AAH09751
AAH13300
AAH80581
AAV38341
AB011446
AB011450
AB519677
AB519678
AB519679
AC135178
AF004022
AF008552
AF015254
AK297976
AURKB
AURKB-201
AURKB-202
AURKB-204
AURKB-214
BAA32136
BAA82709
BAG60286
BAI23190
BAI23191
BAI23192
BC000442
BC009751
BC013300
BC080581
BT019534
CAB005862
CCDS11134
CCDS58514
CCDS67162
CCDS82065
CH471108
EAW90075
EAW90077
EAW90078
ENSG00000178999
ENSP00000313950
ENSP00000443869
ENSP00000462207
ENSP00000463999
ENST00000316199
ENST00000316199.10
ENST00000534871
ENST00000534871.5
ENST00000578549
ENST00000578549.5
ENST00000585124
EntrezGene:9212
EntrezGene:AURKB
g5688865_3p_at
GE62547
GE84968
GO:0000122
GO:0000166
GO:0000228
GO:0000278
GO:0000775
GO:0000776
GO:0000779
GO:0000780
GO:0002903
GO:0003674
GO:0004672
GO:0004674
GO:0004712
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005876
GO:0006259
GO:0006464
GO:0006468
GO:0006511
GO:0007010
GO:0007049
GO:0007051
GO:0007052
GO:0007059
GO:0007094
GO:0007165
GO:0007568
GO:0008150
GO:0008219
GO:0008283
GO:0008608
GO:0009056
GO:0009058
GO:0009838
GO:0010369
GO:0016301
GO:0016310
GO:0016570
GO:0016740
GO:0019899
GO:0019900
GO:0022607
GO:0030496
GO:0031145
GO:0031616
GO:0032091
GO:0032133
GO:0032212
GO:0032465
GO:0032466
GO:0032467
GO:0032991
GO:0034501
GO:0034641
GO:0034644
GO:0035174
GO:0036089
GO:0042592
GO:0043167
GO:0043226
GO:0043988
GO:0044878
GO:0046777
GO:0046872
GO:0048856
GO:0051233
GO:0051256
GO:0051276
GO:0051301
GO:0051973
GO:0051983
GO:0061024
GO:0140014
GO:1901796
GO:1904355
GO:1990023
HGNC:11390
HPA037708
Hs.221197.0.A1_3p_at
Hs.221197.0.A1_3p_x_at
ILMN_1684217
IPR000719
IPR008271
IPR011009
IPR017441
IPR028772
IPR030616
J3KRF8
J3KRJ2
J3KTD6
J3QLN8
J3QR41
MIM:604970
NM_001256834
NM_001284526
NM_001313950
NM_001313951
NM_001313952
NM_001313953
NM_001313955
NM_004217
NP_001243763
NP_001271455
NP_001300879
NP_001300880
NP_001300881
NP_001300882
NP_001300884
NP_004208
NR_132730
PF00069
PH_hs_0025861
SM00220
TC17001109.hg
UPI000013FD00
UPI0000169F3D
UPI00017A78EE
UPI0001B5A99A
XM_011524072
XM_017025307
XM_017025308
XP_011522374
XP_016880796
XP_016880797
Participant Of
hasComponent
Other forms of this molecule
AURKB [nucleoplasm]
AURKB [cytosol]
Inferred To
Homologues of SUMO2,3-K202-AURKB [cytosol] (Drosophila melanogaster)
SUMO2,3-K202-AURKB [cytosol] (Canis familiaris)
SUMO2,3-K202-AURKB [cytosol] (Danio rerio)
SUMO2,3-K202-AURKB [cytosol] (Drosophila melanogaster)
SUMO2,3-K202-AURKB [cytosol] (Mus musculus)
SUMO2,3-K202-AURKB [cytosol] (Rattus norvegicus)
SUMO2,3-K202-AURKB [cytosol] (Sus scrofa)
SUMO2,3-K202-AURKB [cytosol] (Xenopus tropicalis)
Modified Residues
Name
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 202
Coordinate
202
Modification
polySUMO2,3 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
ZINC - Investigational
ZINC - Metabolites
GeneCards
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (20)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:O15392 BIRC5  3 0.954 13
 UniProt:Q9NQS7 INCENP  2 0.953 18
 UniProt:Q53HL2 CDCA8  3 0.847 9
 UniProt:P08238 HSP90AB1  6 0.723 4
 UniProt:Q8WYJ6 SEPT1      0.704 6
 UniProt:Q16543 CDC37  1 0.662 4
 UniProt:Q99986 VRK1  2 0.65 14
 UniProt:Q15691 MAPRE1  1 0.633 5
 UniProt:P06748 NPM1  5 0.626 5
 UniProt:Q92993 KAT5  1 0.602 4
 UniProt:Q86XJ1 GA2L3      0.584 4
 UniProt:Q9NQS7-1 INCENP      0.558 2
 UniProt:Q16695 HIST3H3  3 0.544 8
 UniProt:O15392-2 BIRC5      0.544 2
 UniProt:O15392-1 BIRC5      0.544 2
 UniProt:O75665 OFD1  1 0.527 3
 UniProt:Q16659 MAPK6  6 0.527 2
 UniProt:O75410 TACC1      0.463 2
 UniProt:P06493 CDK1  10 0.463 5
 UniProt:O15027 SEC16A  1 0.462 2