Reactome | polySUMO2,3-K202-AURKB [cytosol]

polySUMO2,3-K202-AURKB [cytosol]

Stable Identifier

R-HSA-4655414

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Aurora B

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
25218447	Uncovering global SUMOylation signaling networks in a site-specific manner Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC	Nat. Struct. Mol. Biol.	2014
21554500	Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis Ban, R, Nishida, T, Urano, T	Genes Cells	2011

External Reference Information

External Reference

UniProt:Q96GD4 AURKB

Gene Names

AURKB, AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5

Chain

chain:1-344

Reference Genes

BioGPS Gene:9212 AURKB

COSMIC (genes):AURKB AURKB

CTD Gene:9212 AURKB

dbSNP Gene:9212 AURKB

ENSEMBL:ENSG00000178999 AURKB

HGNC:11390 AURKB

KEGG:hsa:9212 AURKB

Monarch:9212 AURKB

NCBI Gene:9212 AURKB

OMIM:604970 AURKB

UCSC:Q96GD4 AURKB

Reference Transcript

Other Identifiers

11720203_a_at

16840902

209464_PM_at

209464_at

239219_3p_at

239219_PM_at

239219_at

33266_at

3744271

3744272

3744273

3744274

3744275

3744276

3744277

3744278

3744279

3744280

3744281

3744282

3744283

3744284

3744285

3744286

3744287

3744288

3744289

3744290

3744291

3744292

3744293

3744294

44224_at

8012403

9212

A_23_P130182

GE62547

GE84968

GO:0000122

GO:0000166

GO:0000278

GO:0000281

GO:0000775

GO:0000776

GO:0000779

GO:0000910

GO:0000922

GO:0002376

GO:0002903

GO:0003824

GO:0004672

GO:0004674

GO:0004712

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005876

GO:0006355

GO:0006468

GO:0007010

GO:0007051

GO:0007052

GO:0010369

GO:0015630

GO:0016301

GO:0016740

GO:0019900

GO:0030496

GO:0031117

GO:0032133

GO:0032206

GO:0032465

GO:0032466

GO:0032467

GO:0032886

GO:0034501

GO:0034644

GO:0036089

GO:0043226

GO:0043687

GO:0044839

GO:0044878

GO:0045824

GO:0051233

GO:0051256

GO:0051301

GO:0051315

GO:0051983

GO:0061024

GO:0061952

GO:0062033

GO:0090068

GO:0090267

GO:0090307

GO:0097431

GO:0106310

GO:0140096

GO:0140273

GO:0140896

GO:0160049

GO:1901796

GO:1901970

GO:1902425

GO:1903490

GO:1905116

GO:1990023

GO:1990758

HMNXSV003048163

Hs.221197.0.A1_3p_at

Hs.221197.0.A1_3p_x_at

ILMN_1684217

PH_hs_0025861

TC17001109.hg

g5688865_3p_at

Participates

as a component of

SUMO2,3:Chromosome passenger complex [cytosol] (Homo sapiens)

Other forms of this molecule

AURKB [cytosol]

AURKB [nucleoplasm]

Inferred To

Homologues of polySUMO2,3-K202-AURKB [cytosol] (Drosophila melanogaster)

AURKB [cytosol] (Bos taurus)

AURKB [cytosol] (Sus scrofa)

aurB [cytosol] (Drosophila melanogaster)

aurA [cytosol] (Drosophila melanogaster)

Aurkb [cytosol] (Mus musculus)

Aurkb [cytosol] (Rattus norvegicus)

Ghost homologue of polySUMO2,3-K202-AURKB [cytosol] (Gallus gallus)

aurkb [cytosol] (Xenopus tropicalis)

Modified Residues

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 202

Coordinate

202

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_001300879.1, NP_001271455.1, XP_016880796.1, XP_011522374.1, NP_004208.2, XP_011522372.1, NP_001243763.1, XP_047293006.1, NP_001300880.1, NP_001300881.1, NP_001300882.1, NP_001300883.1, NP_001300884.1

ZINC - World Drugs

AURKB_HUMAN

Guide to Pharmacology - Targets

1937

OpenTargets

ENSG00000178999

ENSEMBL

ENSP00000313950, ENSG00000178999, ENST00000585124, ENST00000534871, ENSP00000443869, ENSP00000463999, ENSP00000462207, ENST00000316199, ENST00000578549

ZINC - FDA approved

AURKB_HUMAN

ZINC - Substances

AURKB_HUMAN

ZINC - Biogenic

AURKB_HUMAN

ZINC target

Q96GD4

PRO

Q96GD4

GlyGen

Q96GD4

PDB

4AF3

ZINC - Investigational

AURKB_HUMAN

ZINC - Metabolites

AURKB_HUMAN

GeneCards

AURKB

HPA

ENSG00000178999-AURKB

Pharos - Targets

Q96GD4

ZINC - Predictions - Purchasable

AURKB_HUMAN

HMDB Protein

HMDBP01421

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NQS7 INCENP	2	INCENP [nucleoplasm] (R-HSA-4655393) INCENP [cytosol] (R-HSA-375311)	0.964	23
UniProt:O15392 BIRC5	3	BIRC5 [cytosol] (R-HSA-50851) BIRC5 [nucleoplasm] (R-HSA-4655344) ub-BIRC5 [cytosol] (R-HSA-8955933)	0.952	13
UniProt:Q53HL2 CDCA8	3	polySUMO2,3-CDCA8 [cytosol] (R-HSA-4655328) CDCA8 [nucleoplasm] (R-HSA-4655357) CDCA8 [cytosol] (R-HSA-375288)	0.868	10
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.834	7
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.784	5
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.712	6
UniProt:Q8WYJ6 SEPT1			0.704	6
UniProt:Q99986 VRK1	2	VRK1 [cytosol] (R-HSA-2995381) VRK1 [nucleoplasm] (R-HSA-2528998)	0.65	14
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.633	5
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.602	4
UniProt:Q86XJ1 GA2L3			0.584	4
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.571	2
UniProt:O15027 SEC16A	1	SEC16A [cytosol] (R-HSA-5685728)	0.569	3
UniProt:Q58FG0 HS905			0.564	2
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.564	3
UniProt:Q9NQS7-1 INCENP			0.558	2
UniProt:O15392-1 BIRC5			0.544	2
UniProt:O15392-2 BIRC5			0.544	2
UniProt:Q16695 H3-4	3	HIST3H3 [nucleoplasm] (R-HSA-181914) Me3K5-HIST3H3 [nucleoplasm] (R-HSA-2245188) Me2K5-HIST3H3 [nucleoplasm] (R-HSA-2245186)	0.544	8
UniProt:Q16659 MAPK6	6	p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) MAPK6 [nucleoplasm] (R-HSA-5692686) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) p-S189 MAPK6 [cytosol] (R-HSA-5687019) MAPK6 [cytosol] (R-HSA-5686979) ub-MAPK6 [cytosol] (R-HSA-5687000)	0.527	2
UniProt:Q9UN86 G3BP2	1	G3BP2 [cytosol] (R-HSA-9729507)	0.527	2
UniProt:Q9UJX3 ANAPC7	2	ANAPC7 [cytosol] (R-HSA-174242) ANAPC7 [nucleoplasm] (R-HSA-174204)	0.527	2
UniProt:O60232 ZNRD2			0.527	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470)	0.527	2
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.527	2
UniProt:A6NHR9 SMHD1			0.527	2
UniProt:Q13618 CUL3	3	CUL3 [cytosol] (R-HSA-975979) CUL3 [nucleoplasm] (R-HSA-5635033) G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516)	0.527	2
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.527	2
UniProt:Q9P2J3 KLHL9	1	KLHL9 [cytosol] (R-HSA-976056)	0.525	2
UniProt:Q9P2N7 KLHL13	1	KLHL13 [cytosol] (R-HSA-976041)	0.525	2
UniProt:Q9HBJ7 UBP29			0.499	3
UniProt:Q8TDD1 DDX54			0.483	2
UniProt:Q9Y5Q9 GTF3C3	1	GTF3C3 [nucleoplasm] (R-HSA-83691)	0.483	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.471	2
UniProt:P06493 CDK1	11	p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) CDK1 [cytosol] (R-HSA-170075) CDK1 [nucleoplasm] (R-HSA-68889) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-Y4-CDK1 [cytosol] (R-HSA-9836187) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424)	0.463	5
UniProt:O75410 TACC1			0.463	2

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