Reactome | polySUMO2,3-K202-AURKB [cytosol]

polySUMO2,3-K202-AURKB [cytosol]

Stable Identifier

R-HSA-4655414

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Aurora B

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
25218447	Uncovering global SUMOylation signaling networks in a site-specific manner Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M	Nat. Struct. Mol. Biol.	2014
21554500	Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis Urano, T, Ban, R, Nishida, T	Genes Cells	2011

External Reference Information

External Reference

UniProt:Q96GD4 AURKB

Gene Names

AURKB, AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5

Chain

chain:1-344

Reference Genes

BioGPS Gene:9212 AURKB

COSMIC (genes):AURKB AURKB

CTD Gene:9212 AURKB

dbSNP Gene:9212 AURKB

ENSEMBL:ENSG00000178999.13 AURKB

HGNC:11390 AURKB

KEGG Gene (Homo sapiens):9212 AURKB

Monarch:9212 AURKB

NCBI Gene:9212 AURKB

OMIM:604970 AURKB

UCSC:Q96GD4 AURKB

Reference Transcript

Other Identifiers

0001780050

11720203_a_at

16840902

209464_PM_at

209464_at

33266_at

3744271

3744272

3744273

3744274

3744275

3744276

3744278

3744279

3744281

3744282

3744283

3744284

3744290

3744291

3744292

3744293

3744294

8012403

9212

A_23_P130182

GE62547

GE84968

GO:0000122

GO:0000166

GO:0000278

GO:0000281

GO:0000775

GO:0000776

GO:0000779

GO:0000910

GO:0001934

GO:0002903

GO:0004672

GO:0004674

GO:0004712

GO:0005515

GO:0005524

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005876

GO:0006351

GO:0006355

GO:0006468

GO:0007010

GO:0007049

GO:0007051

GO:0007052

GO:0007059

GO:0007094

GO:0007568

GO:0008283

GO:0008608

GO:0009838

GO:0010369

GO:0012501

GO:0015630

GO:0016301

GO:0016310

GO:0016570

GO:0016740

GO:0019900

GO:0023052

GO:0030496

GO:0031616

GO:0032091

GO:0032133

GO:0032200

GO:0032212

GO:0032465

GO:0032466

GO:0032467

GO:0032991

GO:0034501

GO:0034644

GO:0035174

GO:0036089

GO:0036211

GO:0043226

GO:0043687

GO:0044878

GO:0046777

GO:0048856

GO:0051233

GO:0051256

GO:0051301

GO:0051973

GO:0051983

GO:0061024

GO:0062033

GO:0090267

GO:0097431

GO:0106310

GO:0140014

GO:0140096

GO:1901796

GO:1901970

GO:1902425

GO:1903490

GO:1904355

GO:1905116

GO:1990023

HMNXSV003048163

Hs.221197.0.A1_3p_at

Hs.221197.0.A1_3p_x_at

ILMN_1684217

PH_hs_0025861

TC17001109.hg

g5688865_3p_at

Participates

as a component of

SUMO2,3:Chromosome passenger complex [cytosol] (Homo sapiens)

Other forms of this molecule

AURKB [nucleoplasm]

AURKB [cytosol]

Inferred To

Homologues of polySUMO2,3-K202-AURKB [cytosol] (Drosophila melanogaster)

Ghost homologue of polySUMO2,3-K202-AURKB [cytosol] (Gallus gallus)

polySUMO2,3-K202-AURKB [cytosol] (Bos taurus)

polySUMO2,3-K202-AURKB [cytosol] (Canis familiaris)

polySUMO2,3-K202-AURKB [cytosol] (Danio rerio)

polySUMO2,3-K202-AURKB [cytosol] (Drosophila melanogaster)

polySUMO2,3-K202-AURKB [cytosol] (Mus musculus)

polySUMO2,3-K202-AURKB [cytosol] (Rattus norvegicus)

polySUMO2,3-K202-AURKB [cytosol] (Xenopus tropicalis)

Modified Residues

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 202

Coordinate

202

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_001300880.1, NP_001300882.1, NP_001300884.1, NP_001243763.1, NP_001300881.1, NP_001300883.1, NP_004208.2, XP_011522374.1, XP_016880796.1, XP_011522372.1, NP_001271455.1, NP_001300879.1

ZINC - World Drugs

AURKB_HUMAN

Guide to Pharmacology - Targets

1937

OpenTargets

ENSG00000178999

ZINC - FDA approved

AURKB_HUMAN

ZINC - Substances

AURKB_HUMAN

ZINC target

Q96GD4

ZINC - Biogenic

AURKB_HUMAN

PRO

Q96GD4

PDB

4AF3

ZINC - Investigational

AURKB_HUMAN

ZINC - Metabolites

AURKB_HUMAN

IntEnz

2.7.11.1

GeneCards

Q96GD4

HPA

ENSG00000178999-AURKB

Ensembl

ENSP00000462207, ENST00000585124, ENSP00000463999, ENST00000578549, ENST00000316199, ENSP00000443869, ENSG00000178999, ENSP00000313950, ENST00000534871

Pharos - Targets

Q96GD4

ZINC - Predictions - Purchasable

AURKB_HUMAN

HMDB Protein

HMDBP01421

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NQS7 INCENP	2	INCENP [nucleoplasm] (R-HSA-4655393) INCENP [cytosol] (R-HSA-375311)	0.953	19
UniProt:O15392 BIRC5	3	ub-BIRC5 [cytosol] (R-HSA-8955933) BIRC5 [nucleoplasm] (R-HSA-4655344) BIRC5 [cytosol] (R-HSA-50851)	0.952	13
UniProt:Q53HL2 CDCA8	3	polySUMO2,3-CDCA8 [cytosol] (R-HSA-4655328) CDCA8 [nucleoplasm] (R-HSA-4655357) CDCA8 [cytosol] (R-HSA-375288)	0.827	9
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.784	5
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.727	5
UniProt:Q8WYJ6 SEPT1			0.704	6
UniProt:Q99986 VRK1	2	VRK1 [nucleoplasm] (R-HSA-2528998) VRK1 [cytosol] (R-HSA-2995381)	0.65	14
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.633	5
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697)	0.626	5
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.602	4
UniProt:Q86XJ1 GA2L3			0.584	4
UniProt:O15027 SEC16A	1	SEC16A [cytosol] (R-HSA-5685728)	0.569	3
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.564	3
UniProt:Q9NQS7-1 INCENP			0.558	2
UniProt:O15392-2 BIRC5			0.544	2
UniProt:O15392-1 BIRC5			0.544	2
UniProt:Q16695 H3-4	3	HIST3H3 [nucleoplasm] (R-HSA-181914) Me3K5-HIST3H3 [nucleoplasm] (R-HSA-2245188) Me2K5-HIST3H3 [nucleoplasm] (R-HSA-2245186)	0.544	8
UniProt:P07900 HSP90AA1	8	HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.527	2
UniProt:Q9UN86 G3BP2	1	G3BP2 [cytosol] (R-HSA-9729507)	0.527	2
UniProt:Q16659 MAPK6	6	ub-MAPK6 [cytosol] (R-HSA-5687000) MAPK6 [cytosol] (R-HSA-5686979) p-S189 MAPK6 [cytosol] (R-HSA-5687019) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) MAPK6 [nucleoplasm] (R-HSA-5692686) p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665)	0.527	2
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.527	2
UniProt:Q9Y5Q9 GTF3C3	1	GTF3C3 [nucleoplasm] (R-HSA-83691)	0.483	2
UniProt:Q8TDD1 DDX54			0.483	2
UniProt:O75410 TACC1			0.463	2
UniProt:P06493 CDK1	10	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.463	5

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