SUMO2,3-K202-AURKB [cytosol]

Stable Identifier
R-HSA-4655414
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Aurora B
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
21554500 Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis

Urano, T, Ban, R, Nishida, T

Genes Cells 2011
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M

Nat. Struct. Mol. Biol. 2014
External Reference Information
External Reference
UniProt:Q96GD4 AURKB
Gene Names
AURKB, AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5
Chain
chain:1-344
Reference Genes
BioGPS Gene:9212 AURKB
COSMIC (genes):AURKB AURKB
CTD Gene:9212 AURKB
dbSNP Gene:9212 AURKB
ENSEMBL:ENSG00000178999 AURKB
HGNC:11390 AURKB
KEGG Gene (Homo sapiens):9212 AURKB
Monarch:9212 AURKB
NCBI Gene:9212 AURKB
OMIM:604970 AURKB
UCSC:Q96GD4 AURKB
Reference Transcript
Other Identifiers
0001780050
11720203_a_at
16840902
209464_at
33266_at
3744271
3744272
3744273
3744274
3744275
3744276
3744278
3744279
3744281
3744282
3744283
3744284
3744290
3744291
3744292
3744293
3744294
8012403
9212
A_23_P130182
GE62547
GE84968
GO:0000122
GO:0000166
GO:0000278
GO:0000775
GO:0000776
GO:0000779
GO:0002903
GO:0003674
GO:0004672
GO:0004674
GO:0004712
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005876
GO:0006259
GO:0006464
GO:0006468
GO:0006511
GO:0007010
GO:0007049
GO:0007051
GO:0007052
GO:0007059
GO:0007094
GO:0007165
GO:0007568
GO:0008150
GO:0008219
GO:0008283
GO:0008608
GO:0009056
GO:0009058
GO:0009838
GO:0010369
GO:0016301
GO:0016310
GO:0016570
GO:0016740
GO:0019899
GO:0019900
GO:0022607
GO:0030496
GO:0031145
GO:0031616
GO:0032091
GO:0032133
GO:0032212
GO:0032465
GO:0032466
GO:0032467
GO:0032991
GO:0034501
GO:0034641
GO:0034644
GO:0035174
GO:0036089
GO:0042592
GO:0043167
GO:0043226
GO:0043988
GO:0044878
GO:0046777
GO:0046872
GO:0048856
GO:0051233
GO:0051256
GO:0051276
GO:0051301
GO:0051973
GO:0051983
GO:0061024
GO:0097431
GO:0106310
GO:0106311
GO:0140014
GO:1901796
GO:1904355
GO:1905116
GO:1990023
HMNXSV003048163
Hs.221197.0.A1_3p_at
Hs.221197.0.A1_3p_x_at
ILMN_1684217
PH_hs_0025861
TC17001109.hg
g5688865_3p_at
Participates
as a component of
Other forms of this molecule
AURKB [nucleoplasm]
AURKB [cytosol]
Inferred To
aurka [cytosol] (Danio rerio)
aurB [cytosol] (Drosophila melanogaster)
Aurkb [cytosol] (Mus musculus)
Aurkb [cytosol] (Rattus norvegicus)
aurkb [cytosol] (Xenopus tropicalis)
Modified Residues
Name
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 202
Coordinate
202
Modification
polySUMO2,3 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GlyGen
PDB
ZINC - Investigational
ZINC - Metabolites
HPA
GeneCards
Ensembl
Pharos - Targets
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (18)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:O15392 BIRC5  3 0.952 13
 UniProt:Q9NQS7 INCENP  2 0.95 18
 UniProt:Q53HL2 CDCA8  3 0.827 9
 UniProt:P08238 HSP90AB1  6 0.723 4
 UniProt:Q8WYJ6 SEPT1      0.704 6
 UniProt:Q99986 VRK1  2 0.65 14
 UniProt:Q16543 CDC37  1 0.649 4
 UniProt:Q15691 MAPRE1  1 0.633 5
 UniProt:P06748 NPM1  10 0.626 5
 UniProt:Q92993 KAT5  1 0.602 4
 UniProt:Q86XJ1 GA2L3      0.584 4
 UniProt:Q9NQS7-1 INCENP      0.558 2
 UniProt:Q16695 H3-4  3 0.544 8
 UniProt:O15392-2 BIRC5      0.544 2
 UniProt:O15392-1 BIRC5      0.544 2
 UniProt:Q16659 MAPK6  6 0.527 2
 UniProt:P06493 CDK1  10 0.463 5
 UniProt:O75410 TACC1      0.463 2
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