SUMOylation of DNA methylation proteins

Stable Identifier
R-HSA-4655427
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Pathway
Species
Homo sapiens
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The known DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B) can be SUMOylated (reviewed in Xu et al. 2010, Denis et al. 2011). SUMOylation affects the catalytic activity of DNMT1 and the protein interactions of DNMT3A.

Literature References
PubMed ID Title Journal Year
21660058 Regulation of mammalian DNA methyltransferases: a route to new mechanisms

Denis, H, Ndlovu, MN, Fuks, F

EMBO Rep. 2011
20939822 Molecular and enzymatic profiles of mammalian DNA methyltransferases: structures and targets for drugs

Xu, F, Mao, C, Ding, Y, Rui, C, Wu, L, Shi, A, Zhang, H, Zhang, L, Xu, Z

Curr. Med. Chem. 2010
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