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AURKA [nucleoplasm]
Stable Identifier
R-HSA-4655443
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Aurora kinase A ecNumber2.7.11.1/ecNumber, AURKA_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Homo sapiens)
GADD45A binds AURKA (Homo sapiens)
AURKA [nucleoplasm] (Homo sapiens)
GADD45A:AURKA [nucleoplasm] (Homo sapiens)
AURKA [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA replication proteins (Homo sapiens)
SUMOylation of AURKA with SUMO1 (Homo sapiens)
AURKA [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14965 AURKA
Gene Names
AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
Chain
chain:1-403
Reference Genes
BioGPS Gene:6790 AURKA
COSMIC (genes):AURKA AURKA
CTD Gene:6790 AURKA
dbSNP Gene:6790 AURKA
ENSEMBL:ENSG00000087586 AURKA
ENSEMBL_homo_sapiens_GENE:ENSG00000087586.18 AURKA
HGNC:11393 AURKA
KEGG Gene (Homo sapiens):6790 AURKA
Monarch:6790 AURKA
NCBI Gene:6790 AURKA
OMIM:603072 AURKA
UCSC:O14965 AURKA
Reference Transcript
RefSeq:NM_198434.2 AURKA
RefSeq:NM_001323303.1 AURKA
RefSeq:NM_198435.2 AURKA
RefSeq:XM_017028035.1 AURKA
RefSeq:NM_003600.3 AURKA
RefSeq:NM_198433.2 AURKA
RefSeq:NM_001323304.1 AURKA
RefSeq:NM_198436.2 AURKA
RefSeq:NM_001323305.1 AURKA
RefSeq:NM_198437.2 AURKA
Other Identifiers
11718943_a_at
11751206_s_at
16920548
204092_PM_s_at
204092_s_at
208079_PM_s_at
208079_s_at
2456937
2456940
2456941
2456943
2456944
3265227
3265230
34851_at
34852_g_at
3910786
3910787
3910788
3910789
3910790
3910791
3910796
3910797
3910800
3910802
3910803
3910804
3910805
3910806
3910807
3910808
6790
8067167
A_23_P131866
GE54110
GO:0000086
GO:0000166
GO:0000212
GO:0000226
GO:0000278
GO:0000776
GO:0000910
GO:0000922
GO:0003824
GO:0004672
GO:0004674
GO:0004712
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005814
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005874
GO:0005876
GO:0005886
GO:0005929
GO:0006325
GO:0006338
GO:0006468
GO:0006915
GO:0007005
GO:0007010
GO:0007049
GO:0007051
GO:0007052
GO:0007057
GO:0007059
GO:0007098
GO:0007100
GO:0009611
GO:0009948
GO:0010389
GO:0010629
GO:0012501
GO:0014069
GO:0015630
GO:0016020
GO:0016301
GO:0016310
GO:0016323
GO:0016740
GO:0018105
GO:0019901
GO:0022414
GO:0023052
GO:0030030
GO:0030154
GO:0030163
GO:0030496
GO:0031616
GO:0031625
GO:0031647
GO:0032091
GO:0032133
GO:0032436
GO:0032465
GO:0035175
GO:0036064
GO:0036211
GO:0042585
GO:0042995
GO:0043005
GO:0043066
GO:0043161
GO:0043203
GO:0043226
GO:0044782
GO:0045120
GO:0045840
GO:0045931
GO:0046605
GO:0046777
GO:0046982
GO:0048471
GO:0048856
GO:0051233
GO:0051301
GO:0051321
GO:0051642
GO:0061523
GO:0071539
GO:0072686
GO:0072687
GO:0090141
GO:0097421
GO:0097431
GO:0098772
GO:0098978
GO:0106310
GO:0140013
GO:0140014
GO:0140096
GO:0140677
GO:1900195
GO:1901796
GO:1990138
HMNXSV003001259
ILMN_1680955
ILMN_2357438
PH_hs_0013285
TC20000968.hg
TC20001661.hg
g4507274_3p_s_at
Participates
as an input of
SUMOylation of AURKA with SUMO1 (Homo sapiens)
GADD45A binds AURKA (Homo sapiens)
as a component of
GADD45A:AURKA [nucleoplasm] (Homo sapiens)
Other forms of this molecule
SUMO1-K258-AURKA [cytosol]
p-T288-AURKA [nucleoplasm]
PolyUb-AURKA [cytosol]
AURKA [cytosol]
p-T288-AURKA [cytosol]
Inferred To
AURKA [nucleoplasm]
(Bos taurus)
AURKA [nucleoplasm]
(Canis familiaris)
AURKA [nucleoplasm]
(Danio rerio)
AURKA [nucleoplasm]
(Drosophila melanogaster)
AURKA [nucleoplasm]
(Gallus gallus)
AURKA [nucleoplasm]
(Mus musculus)
AURKA [nucleoplasm]
(Rattus norvegicus)
AURKA [nucleoplasm]
(Sus scrofa)
AURKA [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_940835.1
,
NP_001310232.1
,
NP_940837.1
,
NP_001310234.1
,
NP_940839.1
,
NP_940836.1
,
XP_016883524.1
,
NP_001310233.1
,
NP_003591.2
,
NP_940838.1
ZINC - World Drugs
AURKA_HUMAN
Guide to Pharmacology - Targets
1936
OpenTargets
ENSG00000087586
ZINC - FDA approved
AURKA_HUMAN
ZINC - Substances
AURKA_HUMAN
ZINC target
O14965
ZINC - Biogenic
AURKA_HUMAN
PRO
O14965
PDB
3UP7
,
3O51
,
5ODT
,
8JF4
,
4J8N
,
5DN3
,
5ORL
,
3W10
,
5ORN
,
3VAP
,
3H0Z
,
8C15
,
2X6D
,
5DR9
,
6HJJ
,
5ORS
,
4DEE
,
8SSO
,
5ONE
,
8C14
,
5ORT
,
5DT3
,
3MYG
,
4CEG
,
2BMC
,
4JBQ
,
3FDN
,
8C1G
,
2W1G
,
6GRA
,
5EW9
,
5ORR
,
3UO6
,
6C2R
,
2XNE
,
5AAE
,
3NRM
,
8C1F
,
3W16
,
3UOJ
,
5ORX
,
6C83
,
2NP8
,
3UOK
,
5ORY
,
4JAI
,
4JBP
,
4O0S
,
5ORW
,
5OS6
,
5ORV
,
3LAU
,
4O0U
,
5OS3
,
1MQ4
,
6R4C
,
6VPG
,
1OL7
,
5AAF
,
6R4B
,
5OS4
,
2J4Z
,
5AAG
,
2W1E
,
5DPV
,
2X81
,
3H10
,
3QBN
,
8OF5
,
4ZTR
,
6I2U
,
3UO5
,
4ZTQ
,
4DEB
,
5ZAN
,
4JAJ
,
8GUW
,
5L8L
,
4B0G
,
4UZD
,
6Z4Y
,
6VPM
,
4C3P
,
6CPF
,
4UYN
,
6CPG
,
5LXM
,
8C1M
,
5DR2
,
3P9J
,
4DHF
,
8C1D
,
7O2V
,
6XKA
,
2WTW
,
5OS5
,
5DT4
,
3R22
,
6HJK
,
3K5U
,
3UOH
,
8JMX
,
3W2C
,
3COH
,
4C3R
,
3UP2
,
4DED
,
5OBR
,
5DT0
,
7FIC
,
5OBJ
,
5OSF
,
3HA6
,
8SSP
,
3R21
,
3W18
,
5OS1
,
5OS2
,
2X6E
,
2C6D
,
3UOL
,
2XNG
,
5DNR
,
5ORZ
,
3EFW
,
2W1F
,
8C1K
,
5OS0
,
4JBO
,
4ZS0
,
2WTV
,
6VPL
,
8C1E
,
5DOS
,
5ORO
,
2C6E
,
5G15
,
6VPJ
,
5ORP
,
3H0Y
,
3UOD
,
2WQE
,
3O50
,
6CPE
,
6VPI
,
1OL5
,
5G1X
,
6R4D
,
2W1C
,
6VPH
,
4BYI
,
4BYJ
,
4ZTS
,
1OL6
,
8C1I
,
7ZTL
,
4J8M
,
4BN1
,
2J50
,
4UZH
,
5DRD
,
2W1D
,
8C1H
,
6R4A
,
2DWB
,
5OSE
,
6C2T
,
5L8K
,
8JG8
,
5OSD
,
6R49
,
4PRJ
,
7AYI
,
5DR6
,
3E5A
,
4O0W
,
7AYH
,
1MUO
,
2XRU
,
3UO4
,
5AAD
,
3M11
,
5L8J
,
3UNZ
,
4DEA
ZINC - Investigational
AURKA_HUMAN
ZINC - Metabolites
AURKA_HUMAN
GeneCards
O14965
HPA
ENSG00000087586-AURKA
Ensembl
ENST00000395914
,
ENST00000312783
,
ENSP00000321591
,
ENSP00000379247
,
ENSP00000379249
,
ENSP00000360407
,
ENSG00000087586
,
ENSP00000379250
,
ENSP00000379251
,
ENST00000371356
,
ENST00000395913
,
ENST00000395911
,
ENST00000395915
,
ENSP00000216911
,
ENST00000347343
Pharos - Targets
O14965
ZINC - Predictions - Purchasable
AURKA_HUMAN
HMDB Protein
HMDBP01317
Interactors (49)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9ULW0 TPX2
2
TPX2 [cytosol]
(R-HSA-8853407)
TPX2 [nucleoplasm]
(R-HSA-2564700)
0.887
10
UniProt:P04198 MYCN
1
MYCN [nucleoplasm]
(R-HSA-452357)
0.834
12
UniProt:Q8TEP8 CEP192
1
CEP192 [cytosol]
(R-HSA-380319)
0.802
8
UniProt:Q6PGQ7 BORA
3
p-S252-BORA [cytosol]
(R-HSA-4086411)
p-S252,S497,T501-BORA [cytosol]
(R-HSA-3000330)
BORA [cytosol]
(R-HSA-2562607)
0.656
3
UniProt:Q9P286 PAK5
2
PAK7 [plasma membrane]
(R-HSA-211555)
PAK5 [cytosol]
(R-HSA-428459)
0.643
3
UniProt:Q9UPY3 DICER1
1
DICER1 [cytosol]
(R-HSA-203820)
0.643
4
UniProt:O15350 TP73
3
PolyUb-TP73 [cytosol]
(R-HSA-8957256)
TP73 [cytosol]
(R-HSA-8957239)
TP73 [nucleoplasm]
(R-HSA-6798094)
0.632
11
UniProt:Q8VDQ8
1
SIRT2 [cytosol]
(R-MMU-2161118)
0.599
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.581
4
UniProt:Q9NQS7-1 INCENP
0.558
2
ChEBI:83432 CD532
0.558
2
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
0.544
2
UniProt:P23468 PTPRD
1
PTPRD [plasma membrane]
(R-HSA-6797868)
0.544
2
UniProt:Q9H792 PEAK1
1
PEAK1 [cytosol]
(R-HSA-9715162)
0.527
2
UniProt:O75170 PP6R2
0.527
3
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.527
2
UniProt:O43379 WDR62
0.527
3
UniProt:Q96DU7 ITPKC
1
ITPKC [cytosol]
(R-HSA-2023850)
0.527
2
UniProt:Q9P1Z2 CACO1
0.527
3
UniProt:P08218 CEL2B
0.527
2
UniProt:Q99689 FEZ1
0.527
2
UniProt:Q99961 SH3GL1
1
SH3GL1 [cytosol]
(R-HSA-8867732)
0.527
3
UniProt:O15496 PLA2G10
1
PLA2G10 [extracellular region]
(R-HSA-1498793)
0.527
2
UniProt:Q96K76 USP47
1
USP47 [nucleoplasm]
(R-HSA-5696961)
0.527
3
UniProt:Q9C0C2 TNKS1BP1
1
TNKS1BP1 [cytosol]
(R-HSA-430011)
0.527
3
UniProt:Q5JTC6 AMER1
5
AMER1 [cytosol]
(R-HSA-1504189)
AMER1 R353* [cytosol]
(R-HSA-9663939)
AMER1 R358* [cytosol]
(R-HSA-4839640)
AMER1 S210* [cytosol]
(R-HSA-5251492)
AMER1 R497* [cytosol]
(R-HSA-9663943)
0.527
2
UniProt:Q9Y5X1 SNX9
3
SNX9 [cytosol]
(R-HSA-8867737)
SNX9 [Golgi membrane]
(R-HSA-432988)
SNX9 [cytoplasmic vesicle membrane]
(R-HSA-432990)
0.527
3
UniProt:A4D1S0 KLRG2
0.527
2
UniProt:Q5H9R7 PPP6R3
2
PPP6R3 [cytosol]
(R-HSA-5685722)
PPP6R3 [nucleoplasm]
(R-HSA-9686574)
0.527
4
UniProt:Q9H7T9 AUNIP
0.527
2
UniProt:Q9UGP4 LIMD1
1
LIMD1 [cytosol]
(R-HSA-8932473)
0.527
2
UniProt:Q96RF0 SNX18
1
SNX18 [cytosol]
(R-HSA-8868038)
0.527
3
UniProt:P14314 PRKCSH
3
PRKCSH [endoplasmic reticulum lumen]
(R-HSA-532666)
p-PRKCSH [endoplasmic reticulum lumen]
(R-HSA-8956890)
PRKCSH [plasma membrane]
(R-HSA-879405)
0.527
2
UniProt:Q86XD5 FAM131B
2
FAM131B(1-18)-BRAF(381-766) fusion [cytosol]
(R-HSA-6802323)
FAM131B(1-18)-p-BRAF(381-766) fusion [cytosol]
(R-HSA-6802527)
0.527
2
UniProt:P19838 NFKB1
8
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.527
3
UniProt:Q9NYA4 MTMR4
2
MTMR4 [cytosol]
(R-HSA-1604658)
MTMR4 [early endosome membrane]
(R-HSA-2187404)
0.527
3
UniProt:P42566 EPS15
2
p-Y849 EPS15 [cytosol]
(R-HSA-8867028)
EPS15 [cytosol]
(R-HSA-182920)
0.527
3
UniProt:Q16659 MAPK6 gene
6
ub-MAPK6 [cytosol]
(R-HSA-5687000)
MAPK6 [cytosol]
(R-HSA-5686979)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
0.527
2
UniProt:Q9BYW2 SETD2
1
SETD2 [nucleoplasm]
(R-HSA-1183220)
0.527
3
UniProt:Q9Y6A5 TACC3
1
TACC3 [cytosol]
(R-HSA-2160956)
0.527
2
UniProt:Q92673 SORL1
2
SORL1 [endosome membrane]
(R-HSA-8871475)
SORL1 [Golgi membrane]
(R-HSA-8871510)
0.527
3
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.525
4
UniProt:O15392 BIRC5
3
ub-BIRC5 [cytosol]
(R-HSA-8955933)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
BIRC5 [cytosol]
(R-HSA-50851)
0.525
2
UniProt:Q9NWT8 AURKAIP1
1
AURKAIP1 [mitochondrial inner membrane]
(R-HSA-5368203)
0.524
2
UniProt:P61978 HNRNPK
2
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
HNRNPK [nucleoplasm]
(R-HSA-71945)
0.524
2
UniProt:Q13123 IK
1
IK [nucleoplasm]
(R-HSA-9770239)
0.524
3
UniProt:Q96R06 SPAG5
0.508
3
UniProt:Q9NQS7 INCENP
2
INCENP [nucleoplasm]
(R-HSA-4655393)
INCENP [cytosol]
(R-HSA-375311)
0.499
2
UniProt:P06748 NPM1
11
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1 [granular component]
(R-HSA-9017702)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
0.489
3
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