Reactome | MBD3 [nucleoplasm]

MBD3 [nucleoplasm]

Stable Identifier

R-HSA-4657010

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Methyl-CpG-binding domain protein 3, MBD3_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MBD3 [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MBD3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95983 MBD3

Gene Names

MBD3

Chain

chain:1-291

Reference Genes

COSMIC (genes):MBD3 MBD3

dbSNP Gene:53615 MBD3

ENSEMBL:ENSG00000071655 MBD3

Participates

as a component of

Inferred To

MBD3 [nucleoplasm] (Bos taurus)

MBD3 [nucleoplasm] (Canis familiaris)

MBD3 [nucleoplasm] (Gallus gallus)

MBD3 [nucleoplasm] (Sus scrofa)

MBD-like [nucleoplasm] (Drosophila melanogaster)

Mbd3 [nucleoplasm] (Mus musculus)

Mbd3 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of MBD3 [nucleoplasm] (Caenorhabditis elegans)

mbd3 [nucleoplasm] (Xenopus tropicalis)

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.899	10
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.812	6
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.812	8
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.758	7
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.597	3
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.597	4
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.597	4
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.547	4
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.527	2
UniProt:P14404 Mecom	1	Mecom [nucleoplasm] (R-MMU-9830485)	0.527	2
UniProt:Q9UJQ4 SALL4	1	SALL4 [nucleoplasm] (R-HSA-452644)	0.527	3
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.527	2
UniProt:Q01860 POU5F1 (OCT4)	1	POU5F1 [nucleoplasm] (R-HSA-452472)	0.499	3
UniProt:O43474 KLF4	1	KLF4 [nucleoplasm] (R-HSA-434463)	0.499	3
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.499	3
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.499	3
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.462	4
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.462	4
UniProt:O60315 ZEB2	1	ZEB2 [nucleoplasm] (R-HSA-3108222)	0.462	5