Reactome | MBD3 [nucleoplasm]

MBD3 [nucleoplasm]

Stable Identifier

R-HSA-4657010

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Methyl-CpG-binding domain protein 3, MBD3_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MBD3 [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MBD3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95983 MBD3

Gene Names

MBD3

Chain

chain:1-291

Reference Genes

BioGPS Gene:53615 MBD3

COSMIC (genes):MBD3 MBD3

CTD Gene:53615 MBD3

dbSNP Gene:53615 MBD3

ENSEMBL:ENSG00000071655 MBD3

ENSEMBL:ENSG00000071655.18 MBD3

HGNC:6918 MBD3

KEGG Gene (Homo sapiens):53615 MBD3

Monarch:53615 MBD3

NCBI Gene:53615 MBD3

OMIM:603573 MBD3

UCSC:O95983 MBD3

Reference Transcript

Other Identifiers

11744359_s_at

11748027_x_at

11748028_a_at

16866709

202463_PM_s_at

202463_s_at

222183_3p_x_at

222183_PM_x_at

222183_x_at

3845317

3845318

3845319

3845320

3845321

3845322

3845323

3845324

3845325

3845327

3845328

3845329

3845333

3845335

3845337

3845346

3845347

41160_PM_at

41160_at

44359_r_at

53615

8032273

8032275

A_23_P50839

A_24_P31527

A_32_P35575

GE58316

GO:0000122

GO:0000785

GO:0000792

GO:0001701

GO:0003677

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006325

GO:0006338

GO:0006346

GO:0006351

GO:0006355

GO:0007507

GO:0008327

GO:0009888

GO:0014070

GO:0016573

GO:0016575

GO:0016581

GO:0030154

GO:0031492

GO:0031667

GO:0032355

GO:0032991

GO:0036211

GO:0042659

GO:0043226

GO:0044030

GO:0045892

GO:0045893

GO:0048568

GO:0048856

GO:2000736

HMNXSV003004738

Hs.208339.0.S1_3p_at

Hs.208339.0.S1_3p_s_at

Hs.208339.0.S1_3p_x_at

ILMN_1698491

PH_hs_0029337

PH_hs_0037177

TC19001008.hg

TC19001009.hg

g7710147_3p_s_at

p8120

Participates

as a component of

Inferred To

MBD3 [nucleoplasm] (Bos taurus)

MBD3 [nucleoplasm] (Canis familiaris)

MBD3 [nucleoplasm] (Danio rerio)

MBD3 [nucleoplasm] (Gallus gallus)

MBD3 [nucleoplasm] (Sus scrofa)

MBD-like [nucleoplasm] (Drosophila melanogaster)

Mbd3 [nucleoplasm] (Mus musculus)

Mbd3 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of MBD3 [nucleoplasm] (Caenorhabditis elegans)

mbd3 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001268383.1, NP_001268382.1

OpenTargets

ENSG00000071655

GeneCards

O95983

HPA

ENSG00000071655-MBD3

Ensembl

ENSP00000412302, ENSP00000156825, ENST00000156825, ENSG00000071655, ENST00000434436

PRO

O95983

Pharos - Targets

O95983

HMDB Protein

HMDBP12767

PDB

6CEU, 2MB7, 6CCG, 6CEV, 6CC8

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.823	6
UniProt:Q92769 HDAC2	2	monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.758	5
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.69	4
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.69	4
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.597	3
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.597	4
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.597	4
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.547	4
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.499	3
UniProt:Q01860 POU5F1	1	POU5F1 [nucleoplasm] (R-HSA-452472)	0.499	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.499	3
UniProt:O43474 KLF4	1	KLF4 [nucleoplasm] (R-HSA-434463)	0.499	3
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.462	4
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.462	4
UniProt:O60315 ZEB2	1	ZEB2 [nucleoplasm] (R-HSA-3108222)	0.462	5