Reactome | CHD3 [nucleoplasm]

CHD3 [nucleoplasm]

Stable Identifier

R-HSA-4657012

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Chromodomain-helicase-DNA-binding protein 3, CHD3_HUMAN

Locations in the PathwayBrowser

Expand all

Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - HDACs deacetylate histones (Homo sapiens)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
      - HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        Mi-2 [nucleoplasm] (Homo sapiens)
        
        CHD3 [nucleoplasm] (Homo sapiens)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        Mi-2 [nucleoplasm] (Homo sapiens)
        
        CHD3 [nucleoplasm] (Homo sapiens)
    - HDAC1:2-containing complex deacetylate histones (Homo sapiens)
      - HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        Mi-2 [nucleoplasm] (Homo sapiens)
        
        CHD3 [nucleoplasm] (Homo sapiens)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        Mi-2 [nucleoplasm] (Homo sapiens)
        
        CHD3 [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        Mi-2 [nucleoplasm] (Homo sapiens)
        
        CHD3 [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        Mi-2 [nucleoplasm] (Homo sapiens)
        
        CHD3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q12873 CHD3

Gene Names

CHD3

Chain

chain:1-2000

Reference Genes

BioGPS Gene:1107 CHD3

COSMIC (genes):CHD3 CHD3

CTD Gene:1107 CHD3

dbSNP Gene:1107 CHD3

ENSEMBL:ENSG00000170004 CHD3

ENSEMBL_homo_sapiens_GENE:ENSG00000170004.19 CHD3

HGNC:1918 CHD3

KEGG Gene (Homo sapiens):1107 CHD3

Monarch:1107 CHD3

NCBI Gene:1107 CHD3

OMIM:602120 CHD3

UCSC:Q12873 CHD3

Reference Transcript

Other Identifiers

1107

11741293_a_at

11741605_a_at

11741606_s_at

11742704_a_at

11750714_a_at

16830789

208806_PM_at

208806_at

208807_PM_s_at

208807_s_at

34707_at

3709247

3709252

3709253

3709254

3709255

3709259

3709260

3709261

3709262

3709263

3709264

3709265

3709266

3709267

3709268

3709269

3709271

3709272

3709273

3709274

3709275

3709276

3709277

3709280

3709281

3709282

3709283

3709284

3709285

3709286

3709287

3709288

3709289

3709292

3709293

3709295

3709296

3709298

3709299

3709300

3709302

3709304

3709306

3709308

3709310

3709312

3709315

3709317

3709318

3709319

3709320

3709321

3709322

3709323

3709324

3709326

51090_at

8004699

89504_at

A_33_P3239287

GO:0000122

GO:0000166

GO:0000785

GO:0000976

GO:0003677

GO:0003682

GO:0003723

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005813

GO:0005815

GO:0005856

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0007010

GO:0007051

GO:0007098

GO:0008270

GO:0016581

GO:0016605

GO:0016787

GO:0016887

GO:0030154

GO:0034451

GO:0042393

GO:0042659

GO:0043226

GO:0045892

GO:0045893

GO:0046872

GO:0140097

GO:0140657

GO:0140658

GO:2000736

HMNXSV003024425

HMNXSV003036814

Hs.25601.1.S2_3p_at

ILMN_1740764

ILMN_2370414

PH_hs_0002256

PH_hs_0040667

TC17000120.hg

g3298561_3p_a_at

Participates

as an input of

as a component of

TRIM28:CHD3 [nucleoplasm] (Bos taurus)

as a member of

Mi-2 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K1971-CHD3 [nucleoplasm]

Inferred To

Chd3 [nucleoplasm] (Mus musculus)

Chd3 [nucleoplasm] (Rattus norvegicus)

Homologues of CHD3 [nucleoplasm] (Caenorhabditis elegans)

Homologues of CHD3 [nucleoplasm] (Drosophila melanogaster)

CHD3 [nucleoplasm] (Bos taurus)

CHD3 [nucleoplasm] (Caenorhabditis elegans)

CHD3 [nucleoplasm] (Canis familiaris)

CHD3 [nucleoplasm] (Drosophila melanogaster)

CHD3 [nucleoplasm] (Schizosaccharomyces pombe)

CHD3 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001005271.2, NP_005843.2, NP_001005273.1

OpenTargets

ENSG00000170004

GeneCards

Q12873

HPA

ENSG00000170004-CHD3

Ensembl

ENST00000358181, ENST00000380358, ENSP00000369716, ENSP00000332628, ENSP00000350907, ENSG00000170004, ENST00000330494

PRO

Q12873

Pharos - Targets

Q12873

Orphanet

29264

HMDB Protein

HMDBP11640

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.805	9
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.788	8
UniProt:Q92769 HDAC2	2	monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.725	5
UniProt:O14519 CDKA1			0.725	6
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.677	8
UniProt:P61956 SUMO2	6	lysyl-G93-SUMO2 [cytosol] (R-HSA-9834803) SUMO2(1-95) [nucleoplasm] (R-HSA-2990837) UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618) SUMO2 [nucleoplasm] (R-HSA-2984281) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm] (R-HSA-9761546)	0.668	3
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.597	4
UniProt:Q8NC51 SERB1			0.581	5
UniProt:O94776 MTA2	1	MTA2 [nucleoplasm] (R-HSA-4657009)	0.577	5
UniProt:Q13263 TRIM28	3	SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm] (R-HSA-3782600) TRIM28 [nucleoplasm] (R-HSA-974998) SUMO2-K554,K575,K676,K750,K779,K804-TRIM28 [nucleoplasm] (R-HSA-9842867)	0.573	4
UniProt:Q5JVS0 HABP4	2	HABP4 [extracellular region] (R-HSA-448329) HABP4 [cytosol] (R-HSA-448328)	0.553	2
UniProt:Q8N6T7 SIRT6	1	SIRT6 [nucleoplasm] (R-HSA-5685963)	0.553	2
UniProt:Q9NRH1 YAE1			0.553	2
UniProt:P21246 PTN	1	PTN [extracellular region] (R-HSA-201500)	0.553	2
UniProt:P02766 TTR	2	TTR [azurophil granule lumen] (R-HSA-6799366) TTR [extracellular region] (R-HSA-976883)	0.553	2
UniProt:Q16891 IMMT	1	IMMT (MIC60) [mitochondrial inner membrane] (R-HSA-8949569)	0.553	2
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.527	3
UniProt:Q86YP4 GATAD2A	1	GATAD2A [nucleoplasm] (R-HSA-3702077)	0.527	4
UniProt:Q8WXI9 GATAD2B	1	GATAD2B [nucleoplasm] (R-HSA-3702079)	0.527	5
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.527	3
UniProt:O95365 ZBT7A			0.508	2
UniProt:Q99728 BARD1	13	BARD1 G623E [nucleoplasm] (R-HSA-9699135) BARD1 C71Y [nucleoplasm] (R-HSA-9700808) BARD1 C53W [nucleoplasm] (R-HSA-9700807) BARD1 G623W [nucleoplasm] (R-HSA-9699148) BARD1 W34R [nucleoplasm] (R-HSA-9699166) BARD1 H68Y [nucleoplasm] (R-HSA-9699151) BARD1 L44R [nucleoplasm] (R-HSA-9699126) BARD1 C50G [nucleoplasm] (R-HSA-9699137) BARD1 C83G [nucleoplasm] (R-HSA-9699139) K6PolyUb-BARD1 [nucleoplasm] (R-HSA-9701024) K6PolyUb,p-T714,T734-BARD1 [nucleoplasm] (R-HSA-9707286) p-T714,T734-BARD1 [nucleoplasm] (R-HSA-5659846) BARD1 [nucleoplasm] (R-HSA-5659775)	0.508	2
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.508	3
UniProt:O75400 PRPF40A	1	PRPF40A [nucleoplasm] (R-HSA-8867890)	0.508	2
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.508	2
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.499	4

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