Reactome: A Curated Pathway Database

Testosterone is converted to 5-alpha-dihydroxytestosterone

Stable Identifier
R-HSA-469659
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The conversion of testosterone to the most potent androgen, 5-alpha-dihydrotestosterone (DHT), is catalyzed by the microsomal 5alpha-steroid reductase enzymes, of which there are three reported types in humans to date (SRD5A1-3) (Andersson S and Russell DW, 1990; Andersson S et al, 1991; Uemura M et al, 2008 respectively). These enzymes are expressed in the prostate and other androgen target sites. Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias, also known as male pseudohermaphroditism (Anwar R et al, 1997). Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor called melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
3-oxo-5-alpha-steroid 4-dehydrogenase activity of SRD5A1-3 [endoplasmic reticulum membrane] SRD5A1-3 [endoplasmic reticulum membrane] 3-oxo-5-alpha-steroid 4-dehydrogenase activity (0003865)
Orthologous Events
Cross References
Rhea