Reactome | KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3

KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3

Stable Identifier

R-HSA-4724279

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

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KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3

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All characterized lysine demethylases other than KDM1A belong to the jumonjiC domain (JmjC) containing family.The JmjC KDMs are members of the Cupin superfamily of mononuclear Fe (II) dependent oxygenases, which are characterized by the presence of a double-stranded beta-helix core fold. The JmjC KDMs require 2 oxoglutarate (2 OG) and molecular oxygen as co substrates, producing, along with formaldehyde, succinate and carbon dioxide. This hydroxylation based mechanism does not require a protonatable lysine e amine group and consequently JmjC containing demethylases are able to demethylate tri , di and monomethylated lysines.
KDM4A-D (JMJD2A-D/JHDM3A-D) catalyse the demethylation of di- or tri-methylated histone H3 at lysine-10 (H3K9Me2/3) (Cloos et al. 2006, Fodor et al. 2006, Whetstine et al. 2007), with a strong preference for Me3 (Whetstine et al. 2007). MINA, a bifunctional histone lysine demethylase and ribosomal histidine hydroxylase, demethylates trimethylated lysine-10 of histone H3 (Lu et al. 2009). KDM4A (JHDM3A) can also demethylate lysine-37 of histone H3 (H3K36Me2/3) (Klose et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16732293	The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3 Cloos, PA, Christensen, J, Agger, K, Maiolica, A, Rappsilber, J, Antal, T, Hansen, KH, Helin, K	Nature	2006
16738407	Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells Fodor, BD, Kubicek, S, Yonezawa, M, O'Sullivan, RJ, Sengupta, R, Perez-Burgos, L, Opravil, S, Mechtler, K, Schotta, G, Jenuwein, T	Genes Dev.	2006
16603238	Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases Whetstine, JR, Nottke, A, Lan, F, Huarte, M, Smolikov, S, Chen, Z, Spooner, E, Li, E, Zhang, G, Colaiácovo, MP, Shi, Y	Cell	2006