KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3

Stable Identifier
R-HSA-4724279
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

All characterized lysine demethylases other than KDM1A belong to the jumonjiC domain (JmjC) containing family.The JmjC KDMs are members of the Cupin superfamily of mononuclear Fe (II) dependent oxygenases, which are characterized by the presence of a double-stranded beta-helix core fold. The JmjC KDMs require 2 oxoglutarate (2 OG) and molecular oxygen as co substrates, producing, along with formaldehyde, succinate and carbon dioxide. This hydroxylation based mechanism does not require a protonatable lysine e amine group and consequently JmjC containing demethylases are able to demethylate tri , di and monomethylated lysines.
KDM4A-D (JMJD2A-D/JHDM3A-D) catalyse the demethylation of di- or tri-methylated histone H3 at lysine-10 (H3K9Me2/3) (Cloos et al. 2006, Fodor et al. 2006, Whetstine et al. 2007), with a strong preference for Me3 (Whetstine et al. 2007). MINA, a bifunctional histone lysine demethylase and ribosomal histidine hydroxylase, demethylates trimethylated lysine-10 of histone H3 (Lu et al. 2009). KDM4A (JHDM3A) can also demethylate lysine-37 of histone H3 (H3K36Me2/3) (Klose et al. 2006).

Literature References
PubMed ID Title Journal Year
16732293 The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

Cloos, PA, Christensen, J, Agger, K, Maiolica, A, Rappsilber, J, Antal, T, Hansen, KH, Helin, K

Nature 2006
16738407 Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells

Fodor, BD, Kubicek, S, Yonezawa, M, O'Sullivan, RJ, Sengupta, R, Perez-Burgos, L, Opravil, S, Mechtler, K, Schotta, G, Jenuwein, T

Genes Dev. 2006
16603238 Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

Whetstine, JR, Nottke, A, Lan, F, Huarte, M, Smolikov, S, Chen, Z, Spooner, E, Li, E, Zhang, G, Colaiácovo, MP, Shi, Y

Cell 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone demethylase activity of KDM4A, KDM4B, KDM4C, KDM4D, MINA [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed