TOPORS SUMOylates IKBKE with SUMO1

Stable Identifier
R-HSA-4755478
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TOPORS SUMOylates phosphorylated IKBKE (IKKI, IKKE) with SUMO1 at lysine-231 (Renner et al. 2010). SUMOylation causes IKBKE to localize with PML in the nucleus and is required for IKBKE to trigger phosphorylation of NF-kappaB p65.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of TOPORS [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created