TOPORS SUMOylates IKBKE with SUMO1

Stable Identifier
R-HSA-4755478
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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TOPORS SUMOylates IKBKE with SUMO1
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TOPORS SUMOylates phosphorylated IKBKE (IKKI, IKKE) with SUMO1 at lysine-231 (Renner et al. 2010). SUMOylation causes IKBKE to localize with PML in the nucleus and is required for IKBKE to trigger phosphorylation of NF-kappaB p65.

Literature References
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of TOPORS [nucleoplasm]
Physical Entity
TOPORS [nucleoplasm]
Activity
SUMO transferase activity (0019789)
Orthologous Events
TOPORS SUMOylates IKBKE with SUMO1 (Bos taurus)
TOPORS SUMOylates IKBKE with SUMO1 (Canis familiaris)
TOPORS SUMOylates IKBKE with SUMO1 (Danio rerio)
TOPORS SUMOylates IKBKE with SUMO1 (Gallus gallus)
TOPORS SUMOylates IKBKE with SUMO1 (Mus musculus)
TOPORS SUMOylates IKBKE with SUMO1 (Rattus norvegicus)
TOPORS SUMOylates IKBKE with SUMO1 (Sus scrofa)
TOPORS SUMOylates IKBKE with SUMO1 (Xenopus tropicalis)
Authored
May, B  (2013-10-20)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-25)