Reactome | p-S172-IKBKE [nucleoplasm]

p-S172-IKBKE [nucleoplasm]

Stable Identifier

R-HSA-4755521

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

IKKE-P, Inhibitor of nuclear factor kappa-B kinase epsilon subunit

Locations in the PathwayBrowser for interactor UniProt:Q9BYX4

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External Reference Information

External Reference

UniProt:Q14164 IKBKE

Gene Names

IKBKE, IKKE, IKKI, KIAA0151

Chain

chain:1-716

Reference Genes

BioGPS Gene:9641 IKBKE

COSMIC (genes):IKBKE IKBKE

CTD Gene:9641 IKBKE

dbSNP Gene:9641 IKBKE

ENSEMBL:ENSG00000263528 IKBKE

HGNC:14552 IKBKE

KEGG Gene (Homo sapiens):9641 IKBKE

Monarch:9641 IKBKE

NCBI Gene:9641 IKBKE

OMIM:605048 IKBKE

UCSC:Q14164 IKBKE

Reference Transcript

Other Identifiers

0004590017

0004780706

11720956_a_at

11720957_a_at

16676592

204549_at

214398_s_at

2376798

2376800

2376801

2376802

2376807

2376808

2376809

2376810

2376812

2376816

2376817

2376818

2376820

2376821

2376822

2376823

2376824

2376825

2376826

2376830

2376831

2376832

2376833

2376835

2376836

2376837

2376838

2376839

2376840

33281_at

7909188

9641

D63485_at

GE61317

GO:0000166

GO:0002376

GO:0003674

GO:0004672

GO:0004674

GO:0004704

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005768

GO:0005829

GO:0006464

GO:0006468

GO:0006950

GO:0006955

GO:0006974

GO:0007165

GO:0007252

GO:0008150

GO:0008219

GO:0008384

GO:0008630

GO:0010008

GO:0010884

GO:0016032

GO:0016301

GO:0016310

GO:0016605

GO:0016740

GO:0018105

GO:0019899

GO:0019903

GO:0030234

GO:0031410

GO:0031625

GO:0031966

GO:0032480

GO:0034340

GO:0035456

GO:0035666

GO:0036435

GO:0038061

GO:0042802

GO:0043123

GO:0043167

GO:0043226

GO:0044403

GO:0060340

GO:0098586

HMNXSV003030390

Hs.321045.1.S1_3p_a_at

ILMN_1755024

PH_hs_0016042

TC01001723.hg

g7661945_3p_at

Participates

as an input of

TOPORS SUMOylates IKBKE with SUMO1 (Homo sapiens)

Other forms of this molecule

IKBKE [cytosol]

p-S172-IKBKE [cytosol]

SUMO1-K231-p-S172-IKBKE [nucleoplasm]

Inferred To

phospho-ikbke [nucleoplasm] (Danio rerio)

phospho-Ikbke [nucleoplasm] (Mus musculus)

phospho-Ikbke [nucleoplasm] (Rattus norvegicus)

phospho-IKBKE [nucleoplasm] (Gallus gallus)

Modified Residues

Name

O-phospho-L-serine at 172

Coordinate

172

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_054721.1, NP_001180250.1, XP_005273413.1, NP_001180251.1

ZINC - World Drugs

IKKE_HUMAN

OpenTargets

ENSG00000263528

ZINC - FDA approved

IKKE_HUMAN

ZINC - Substances

IKKE_HUMAN

ZINC - Biogenic

IKKE_HUMAN

ZINC target

Q14164

PRO

Q14164

ZINC - Investigational

IKKE_HUMAN

IntEnz

2.7.11.10

GeneCards

Q14164

HPA

ENSG00000263528-IKBKE

Ensembl

ENSP00000462396, ENSG00000263528, ENST00000581977, ENST00000584998, ENSP00000464030

ZINC - Predictions - Purchasable

IKKE_HUMAN

HMDB Protein

HMDBP09508

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92844 TANK	2	TANK [cytosol] (R-HSA-933407) K63polyUb-TANK [cytosol] (R-HSA-5362480)	0.779	4
UniProt:Q7Z434 MAVS	2	K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463) MAVS [mitochondrial outer membrane] (R-HSA-913730)	0.77	4
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.77	4
UniProt:A7MCY6 TBKB1			0.723	4
UniProt:O00571 DDX3X	3	DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273) DDX3X [secretory granule lumen] (R-HSA-6801275)	0.697	4
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.675	4
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) p-S172-TBK1 [cytosol] (R-HSA-450290) TBK1 [cytosol] (R-HSA-166267)	0.669	5
UniProt:Q05127 VP35			0.602	3
UniProt:P60660 MYL6	2	MYL6 [cytosol] (R-HSA-419186) p-S20-MYL6 [cytosol] (R-HSA-445778)	0.589	2
UniProt:P19105 MYL12A	2	MYL12A [cytosol] (R-HSA-390735) p-S19-MYL12A [cytosol] (R-HSA-390749)	0.589	2
UniProt:Q00610 CLTC	6	CLTC [clathrin-coated endocytic vesicle membrane] (R-HSA-5138450) CLTC [plasma membrane] (R-HSA-2980668) CLTC [endolysosome membrane] (R-HSA-8870827) CLTC [cytosol] (R-HSA-8856820) CLTC [lysosomal membrane] (R-HSA-2980660) CLTC [trans-Golgi network membrane] (R-HSA-5333703)	0.589	2
UniProt:P0DP25 CALM			0.589	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.589	3
UniProt:P06753 TPM3	1	TPM3 [cytosol] (R-HSA-390543)	0.589	2
UniProt:P35580 MYH10	1	MYH10 [cytosol] (R-HSA-419174)	0.589	2
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.589	2
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.564	2
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.564	2
UniProt:Q14653 IRF3	4	IRF3 [cytosol] (R-HSA-166251) p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-4S,T404-IRF3 [cytosol] (R-HSA-166258)	0.544	2
UniProt:P27958-PRO_0000037572			0.524	2
UniProt:K7Y1A2 K7Y1A2			0.524	2
UniProt:Q9BYX4 IFIH1	3	K48polyUb-IFIH1 [cytosol] (R-HSA-3080557) PolyUb-IFIH1 [cytosol] (R-HSA-6782812) IFIH1 [cytosol] (R-HSA-913536)	0.499	2
UniProt:Q92624 APBP2			0.499	4
UniProt:I0DF37 I0DF37			0.463	4

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