p-S303,307-HSF1 binds YWHAE (14-3-3)

Stable Identifier
R-HSA-4793925
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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YWHAE (14-3-3epsilon) was found to bind directly to HSF1 and that binding required serine phosphorylation at Ser303 and Ser307 and, moreover, the strongest binding was detected when both residues were phosphorylated.

Literature References
PubMed ID Title Journal Year
12917326 Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1

Wang, X, Grammatikakis, N, Siganou, A, Calderwood, SK

Mol. Cell. Biol. 2003
15364926 Interactions between extracellular signal-regulated protein kinase 1, 14-3-3epsilon, and heat shock factor 1 during stress

Wang, X, Grammatikakis, N, Siganou, A, Stevenson, MA, Calderwood, SK

J. Biol. Chem. 2004
Participants
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Orthologous Events
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