POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter

Stable Identifier
R-HSA-480685
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Formation of OCT4:SOX2:NANOG Complex at SOX2 Promoter
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POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter
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POU5F1 (OCT4), SOX2, and NANOG bind distinct sites in the promoter of the SOX2 gene (Boyer et al. 2005, Jin et al. 2007, Lister et al. 2009, Jung et al. 2010). The set of target genes of POU5F1, SOX2, and NANOG includes POU5F1, SOX2, and NANOG themselves, thus their expression is a component of an autoregulatory loop (Boyer et al. 2005, Chew et al. 2005, Rodda et al. 2005, Babaie et al. 2007, Jung et al. 2010, Goke et al. 2011).

Literature References
PubMed ID Title Journal Year
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Boyer, LA, Lee, TI, Cole, MF, Johnstone, SE, Levine, SS, Zucker, JP, Guenther, MG, Kumar, RM, Murray, HL, Jenner, RG, Gifford, DK, Melton, DA, Jaenisch, R, Young, RA

Cell 2005
19829295 Human DNA methylomes at base resolution show widespread epigenomic differences

Lister, R, Pelizzola, M, Dowen, RH, Hawkins, RD, Hon, G, Tonti-Filippini, J, Nery, JR, Lee, L, Ye, Z, Ngo, QM, Edsall, L, Antosiewicz-Bourget, J, Stewart, R, Ruotti, V, Millar, AH, Thomson, JA, Ren, B, Ecker, JR

Nature 2009
15860457 Transcriptional regulation of nanog by OCT4 and SOX2

Rodda, DJ, Chew, JL, Lim, LH, Loh, YH, Wang, B, Ng, HH, Robson, P

J Biol Chem 2005
17567999 Identification of an OCT4 and SRY regulatory module using integrated computational and experimental genomics approaches

Jin, VX, O'Geen, H, Iyengar, S, Green, R, Farnham, PJ

Genome Res. 2007
22215994 Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development

Göke, J, Jung, M, Behrens, S, Chavez, L, O'Keeffe, S, Timmermann, B, Lehrach, H, Adjaye, J, Vingron, M

PLoS Comput. Biol. 2011
20505756 A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells

Jung, M, Peterson, H, Chavez, L, Kahlem, P, Lehrach, H, Vilo, J, Adjaye, J

PLoS One 2010
15988017 Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells

Chew, JL, Loh, YH, Zhang, W, Chen, X, Tam, WL, Yeap, LS, Li, P, Ang, YS, Lim, B, Robson, P, Ng, HH

Mol Cell Biol 2005
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Herwig, R, Greber, B, Brink, TC, Wruck, W, Groth, D, Lehrach, H, Burdon, T, Adjaye, J

Stem Cells 2007
Participants
Input
Output
Participant Of
hasEvent
Authored
May, B  (2010-11-12)
Reviewed
Wang, J  (2014-01-23)
Created
May, B  (2010-01-27)
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