Exocytosis of platelet alpha granule contents

Stable Identifier
R-HSA-481007
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Exocytosis of platelet alpha granule contents
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Alpha granules contain mainly polypeptides such as fibrinogen, von Willebrand factor, growth factors and protease inhibitors that supplement thrombin generation at the site of injury. In addtion to their role in hemostasis, platelets also contain angiogenesis stimulators and inhibitors (Italiano et al. 2008).
Literature References
PubMed ID Title Journal Year
23640497 High precision platelet releasate definition by quantitative reversed protein profiling--brief report

Wijten, P, van Holten, T, Woo, LL, Bleijerveld, OB, Roest, M, Heck, AJ, Scholten, A

Arterioscler. Thromb. Vasc. Biol. 2013
8467233 Platelet alpha-granules

Harrison, P, Cramer, EM

Blood Rev 1993
6457647 Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa.

Gogstad, GO, Hagen, I, Korsmo, R, Solum, NO

Biochim Biophys Acta 1981
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Orthologous Events
Exocytosis of platelet alpha granule contents (Bos taurus)
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Exocytosis of platelet alpha granule contents (Dictyostelium discoideum)
Exocytosis of platelet alpha granule contents (Drosophila melanogaster)
Exocytosis of platelet alpha granule contents (Gallus gallus)
Exocytosis of platelet alpha granule contents (Mus musculus)
Exocytosis of platelet alpha granule contents (Plasmodium falciparum)
Exocytosis of platelet alpha granule contents (Rattus norvegicus)
Exocytosis of platelet alpha granule contents (Saccharomyces cerevisiae)
Exocytosis of platelet alpha granule contents (Schizosaccharomyces pombe)
Exocytosis of platelet alpha granule contents (Sus scrofa)
Exocytosis of platelet alpha granule contents (Xenopus tropicalis)
Authored
de Bono, B  (2004-09-25)
Pace, NP  (2004-09-25)
Farndale, R  (2004-09-25)
Created
Jupe, S  (2010-01-27)
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