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Exocytosis of platelet dense granule content
Stable Identifier
R-HSA-481009
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet dense granule content (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ADP is the most important constituent of dense granules, essential for recruiting platelets to the site of vascular injury. Other components include ATP, Ca++, GDP, GTP, Mg++, orthophospate, pyrophosphate, and serotonin.
Literature References
PubMed ID
Title
Journal
Year
1435334
Isolation of dense granules from human platelets
Fukami, MH
Methods Enzymol
1992
Participants
Input
Platelet dense granule content [platelet dense granule lumen]
(Homo sapiens)
Output
Platelet dense granule content [extracellular region]
(Homo sapiens)
Participates
as an event of
Platelet degranulation (Homo sapiens)
Orthologous Events
Exocytosis of platelet dense granule content (Bos taurus)
Exocytosis of platelet dense granule content (Caenorhabditis elegans)
Exocytosis of platelet dense granule content (Canis familiaris)
Exocytosis of platelet dense granule content (Danio rerio)
Exocytosis of platelet dense granule content (Dictyostelium discoideum)
Exocytosis of platelet dense granule content (Drosophila melanogaster)
Exocytosis of platelet dense granule content (Gallus gallus)
Exocytosis of platelet dense granule content (Mus musculus)
Exocytosis of platelet dense granule content (Plasmodium falciparum)
Exocytosis of platelet dense granule content (Rattus norvegicus)
Exocytosis of platelet dense granule content (Saccharomyces cerevisiae)
Exocytosis of platelet dense granule content (Schizosaccharomyces pombe)
Exocytosis of platelet dense granule content (Sus scrofa)
Exocytosis of platelet dense granule content (Xenopus tropicalis)
Authored
Farndale, R (2004-09-25)
Pace, NP (2004-09-25)
de Bono, B (2004-09-25)
Created
Jupe, S (2010-01-27)
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