SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)

Stable Identifier
R-HSA-4827382
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate Me2K10-histone H3 (H3K9), SUV39H1, SUV39H2, SETDB1, SETDB2 methylate Me2K10-histone H3
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SUV39H1 (KMT1A) and SUV39H2 (KMT1B) and SETDB2 (KMT1F) selectively methylate lysine-10 of histone H3 (H3K9) (Rea et al. 2000, Rice et al. 2003, Falandry et al. 2010). Their predominant activity is conversion of dimethylated H3K9 to trimethylated H3K9 (Peters et al. 2003, Rice et al. 2003, Chin et al. 2006). SETDB1 (ESET, KMT1E) also predominantly methylates dimethylated H3K9 (Schultz et al. 2002), most effectively when complexed with ATF7IP (MCAF, hAM) (Wang et al. 2003).

Literature References
PubMed ID Title Journal Year
16519522 Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis

Chin, HG, Patnaik, D, Estève, PO, Jacobsen, SE, Pradhan, S

Biochemistry 2006
14690610 Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains

Rice, JC, Briggs, SD, Ueberheide, B, Barber, CM, Shabanowitz, J, Hunt, DF, Shinkai, Y, Allis, CD

Mol Cell 2003
11959841 SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

Schultz, DC, Ayyanathan, K, Negorev, D, Maul, GG, Rauscher, FJ

Genes Dev. 2002
10949293 Regulation of chromatin structure by site-specific histone H3 methyltransferases

Rea, S, Eisenhaber, F, O'Carroll, D, Strahl, BD, Sun, ZW, Schmid, M, Opravil, S, Mechtler, K, Ponting, CP, Allis, CD, Jenuwein, T

Nature 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone-lysine N-methyltransferase activity of SUV39H1, SUV39H2, SETDB1, SETDB2 [nucleoplasm]
Physical Entity
Activity
This event is regulated
Orthologous Events
Authored
Reviewed
Created