Reactome | YWHAB [cytosol]

YWHAB [cytosol]

Stable Identifier

R-HSA-48888

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

14-3-3 protein beta/alpha, 143B protein, Protein kinase C inhibitor protein-1, KCIP-1, Protein 1054

Locations in the PathwayBrowser for interactor UniProt:O43524

Expand all

External Reference Information

External Reference

UniProt:P31946 YWHAB

Gene Names

YWHAB

Chain

initiator methionine:1, chain:1-246, chain:2-246

Reference Genes

BioGPS Gene:7529 YWHAB

COSMIC (genes):YWHAB YWHAB

CTD Gene:7529 YWHAB

dbSNP Gene:7529 YWHAB

ENSEMBL:ENSG00000166913 YWHAB

HGNC:12849 YWHAB

KEGG Gene (Homo sapiens):7529 YWHAB

Monarch:7529 YWHAB

NCBI Gene:7529 YWHAB

OMIM:601289 YWHAB

Reference Transcript

Other Identifiers

0004730725

0006900450

11725042_a_at

11725043_a_at

11725044_s_at

11731397_a_at

11757887_x_at

16914103

208743_s_at

217717_s_at

217718_s_at

32324_at

3886640

3886643

3886644

3886649

3886650

3886652

3886654

3886655

3886656

3886657

3886658

3886659

3886661

3886662

7529

8062880

A_23_P120414

A_23_P500251

GE81853

GO:0000165

GO:0003674

GO:0004860

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005739

GO:0005773

GO:0005774

GO:0005829

GO:0005925

GO:0006464

GO:0006469

GO:0006605

GO:0006810

GO:0007005

GO:0007165

GO:0008022

GO:0008150

GO:0008219

GO:0009056

GO:0009058

GO:0015031

GO:0016020

GO:0016032

GO:0017053

GO:0019899

GO:0019904

GO:0030234

GO:0031410

GO:0032991

GO:0034641

GO:0034655

GO:0035308

GO:0035329

GO:0042470

GO:0042802

GO:0042826

GO:0043085

GO:0043226

GO:0043488

GO:0044403

GO:0044877

GO:0045296

GO:0045744

GO:0045892

GO:0048471

GO:0050815

GO:0051219

GO:0051220

GO:0061024

GO:0070062

GO:1900740

HMNXSV003042369

Hs.182238.0.A1_3p_a_at

ILMN_1694385

ILMN_1799494

ILMN_2277099

PH_hs_0023424

TC20000337.hg

X57346_at

g12655022_3p_a_at

g12655022_3p_s_at

g7661715_3p_a_at

Participates

as a component of

as an input of

as a member of

14-3-3 beta, zeta [cytosol] (Homo sapiens)

Inferred To

14-3-3zeta [cytosol] (Drosophila melanogaster)

par-5 [cytosol] (Caenorhabditis elegans)

ywhab [cytosol] (Xenopus tropicalis)

Ghost homologue of YWHAB [cytosol] (Dictyostelium discoideum)

Ywhab [cytosol] (Rattus norvegicus)

ywhabb [cytosol] (Danio rerio)

14-3-3 beta/alpha [cytosol] (Mus musculus)

YWHAB [cytosol] (Bos taurus)

YWHAB [cytosol] (Canis familiaris)

YWHAB [cytosol] (Gallus gallus)

YWHAB [cytosol] (Plasmodium falciparum)

YWHAB [cytosol] (Sus scrofa)

Homologues of YWHAB [cytosol] (Caenorhabditis elegans)

Homologues of YWHAB [cytosol] (Plasmodium falciparum)

ftt-2 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_003395.1, XP_016883528.1, NP_647539.1

OpenTargets

ENSG00000166913

GeneCards

P31946

HPA

ENSG00000166913-YWHAB

Ensembl

ENSG00000166913, ENSP00000361930, ENST00000353703, ENSP00000300161, ENST00000372839

PRO

P31946

HMDB Protein

HMDBP09171

PDB

4DNK, 5N10, 6GN0, 6BYK, 2C23, 6A5Q, 6GNJ, 6HEP, 6GN8, 6GNN, 6GNK, 2BQ0

Interactors (111)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04049 RAF1	54	p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098) p-S621-RAF1 G361A [cytosol] (R-HSA-9656092) p-S621-RAF1 G370R [cytosol] (R-HSA-9656094) p-S621-RAF1 D486G [cytosol] (R-HSA-9656085) p-S621-RAF1 T491R [cytosol] (R-HSA-9656145) p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol] (R-HSA-9656026) p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol] (R-HSA-9656070) p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol] (R-HSA-9656035) p-S338,Y341,S494,S621-RAF1 T491I [cytosol] (R-HSA-9656019) p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol] (R-HSA-9656029) p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol] (R-HSA-9656031) p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol] (R-HSA-9656023) p-S338,Y341,S494,S621 RAF1 T491R [cytosol] (R-HSA-9656017) p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol] (R-HSA-9656062) p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol] (R-HSA-9656041) p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol] (R-HSA-9656058) p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol] (R-HSA-9656043) p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol] (R-HSA-9656053) p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol] (R-HSA-9656037) p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol] (R-HSA-9656050) p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol] (R-HSA-9656067) p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol] (R-HSA-9656077) p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol] (R-HSA-9656047) p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol] (R-HSA-9656056) p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol] (R-HSA-9656074) p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol] (R-HSA-9656080) p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol] (R-HSA-9656065) RAF1 [cytosol] (R-HSA-167205) p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.934	20
UniProt:P49815 TSC2	4	p-S939,T1462-TSC2 [cytosol] (R-HSA-199484) p-S939,S1130,T1462-TSC2 [cytosol] (R-HSA-165164) TSC2 [cytosol] (R-HSA-2980548) p-S1387-TSC2 [cytosol] (R-HSA-3132769)	0.93	11
UniProt:P30305 CDC25B	3	CDC25B [cytosol] (R-HSA-157412) p-S50,T69,S160,S321,S470-CDC25B [cytosol] (R-HSA-8863644) CDC25B [nucleoplasm] (R-HSA-69734)	0.857	7
UniProt:P08069 IGF1R	3	IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.832	7
UniProt:P15056 BRAF	68	p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF-MACF1fusion [cytosol] (R-HSA-6802402) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469R [cytosol] (R-HSA-9648621) BRAF L597R [cytosol] (R-HSA-9648617) BRAF G469E [cytosol] (R-HSA-9648618) BRAF L597Q [cytosol] (R-HSA-9648619) BRAF G466A [cytosol] (R-HSA-9648613) BRAF G466V [cytosol] (R-HSA-9648838) BRAF N581S [cytosol] (R-HSA-9648850) BRAF G464V [cytosol] (R-HSA-9648611) p-BRAF L597V [plasma membrane] (R-HSA-8936647) p-BRAF L505H [plasma membrane] (R-HSA-9648862) p-BRAF G464E [plasma membrane] (R-HSA-8936645) p-BRAF F595L [plasma membrane] (R-HSA-8936641) p-BRAF A246P [plasma membrane] (R-HSA-9651188) p-BRAF E586K [plasma membrane] (R-HSA-8936639) p-BRAF N581D [plasma membrane] (R-HSA-9651191) p-BRAF V600K [plasma membrane] (R-HSA-8936651) p-BRAF G464V [plasma membrane] (R-HSA-9648633) p-BRAF T244P [plasma membrane] (R-HSA-9651194) p-BRAF G469E [plasma membrane] (R-HSA-9648634) p-BRAF G466V [plasma membrane] (R-HSA-9648859) p-BRAF G469V [plasma membrane] (R-HSA-9648628) p-BRAF G466A [plasma membrane] (R-HSA-9648629) p-BRAF L597Q [plasma membrane] (R-HSA-9648630) p-BRAF L597R [plasma membrane] (R-HSA-9648631) p-BRAF N581S [plasma membrane] (R-HSA-9648866) p-BRAF G469R [plasma membrane] (R-HSA-9648627) BRAF 599dupT [cytosol] (R-HSA-6802281) BRAF G534R [cytosol] (R-HSA-9651134) BRAF S467A [cytosol] (R-HSA-9651161) BRAF K601N [cytosol] (R-HSA-9648857) BRAF G469A [cytosol] (R-HSA-6802381) BRAF L485F [cytosol] (R-HSA-9651147) BRAF Q257R [cytosol] (R-HSA-9651157) BRAF K499E [cytosol] (R-HSA-9651142) BRAF V600E [cytosol] (R-HSA-6802498) BRAF K601E [cytosol] (R-HSA-9648833) BRAF V600E V169_M438del [cytosol] (R-HSA-6802489) BRAF V600E V47_D380del [cytosol] (R-HSA-6802491) BRAF V600E V47_M438del [cytosol] (R-HSA-6802495) V600E BRAF V169_D380del [cytosol] (R-HSA-6802486) p-S445,S729-BRAF [plasma membrane] (R-HSA-8933622) p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF [cytosol] (R-HSA-167224) p-S365,S445,S729 BRAF [cytosol] (R-HSA-5672667) hyperphosphorylated BRAF [plasma membrane] (R-HSA-5675199) p-S445,T599,S602,S729 BRAF [plasma membrane] (R-HSA-5672679) p-S445,S729-BRAF [cytosol] (R-HSA-5672673) p-S445,T599,S602,S729 BRAF [cytosol] (R-HSA-5672676)	0.818	7
UniProt:P46937 YAP1	7	p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.802	6
UniProt:P27448 MARK3	1	MARK3 [cytosol] (R-HSA-5672591)	0.77	6
UniProt:Q96TC7 RMD3			0.767	7
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.764	6
UniProt:Q9Y2J2 EPB41L3	1	EPB41L3 [cytosol] (R-HSA-6797563)	0.758	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.75	5
UniProt:P30291 WEE1	3	p-WEE1 [nucleoplasm] (R-HSA-156491) p-S53-WEE1 [nucleoplasm] (R-HSA-156694) WEE1 [nucleoplasm] (R-HSA-69253)	0.736	4
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.725	5
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.725	4
UniProt:P22893	2	Zfp36 [cytosol] (R-MMU-450562) phospho-Zfp36 [cytosol] (R-MMU-450496)	0.725	5
UniProt:P30304 CDC25A	6	p-S123-CDC25A [nucleoplasm] (R-HSA-143488) CDC25A [nucleoplasm] (R-HSA-143487) CDC25A [cytosol] (R-HSA-157410) p-S123-CDC25A [cytosol] (R-HSA-69588) p-S40,S116,S261-CDC25A [nucleoplasm] (R-HSA-8863634) PolyUb-CDC25A [cytosol] (R-HSA-6782810)	0.701	10
UniProt:P26045 PTPN3	3	p-S459 PTPN3 [cytosol] (R-HSA-8868111) PTPN3 [plasma membrane] (R-HSA-5490317) PTPN3 [cytosol] (R-HSA-8867650)	0.695	5
UniProt:Q16890 TPD52L1	2	TPD52L1 [cytoplasmic vesicle lumen] (R-HSA-434220) TPD52L1 [Golgi lumen] (R-HSA-434331)	0.691	4
UniProt:Q9Y2A7 NCKAP1	1	NCKAP1 [cytosol] (R-HSA-200979)	0.688	3
UniProt:Q96F86 EDC3	1	EDC3 [cytosol] (R-HSA-429997)	0.688	4
UniProt:Q6PKG0 LARP1			0.688	4
UniProt:Q6ICG6 K0930			0.688	3
UniProt:Q7Z401 DENND4A	1	DENND4A [cytosol] (R-HSA-8876072)	0.688	4
UniProt:Q14C86 GAPVD1	1	GAPVD1 [cytosol] (R-HSA-8871123)	0.688	3
UniProt:Q86X27 RGPS2			0.688	4
UniProt:Q12802 AKAP13	1	AKAP13 [cytosol] (R-HSA-2975983)	0.688	3
UniProt:Q9Y2U5 M3K2			0.688	3
UniProt:Q8TEW0 PARD3	3	PARD3 [plasma membrane] (R-HSA-419980) PARD3 [cell junction] (R-HSA-2134481) PARD3 [cytosol] (R-HSA-419993)	0.688	3
UniProt:Q96NE9 FRMD6			0.688	3
UniProt:Q9UBF8 PI4KB	2	PI4KB [Golgi membrane] (R-HSA-1806202) PI4KB [cytosol] (R-HSA-1604615)	0.688	4
UniProt:P40818 USP8	2	p-T945-USP8 [cytosol] (R-HSA-1358714) USP8 [cytosol] (R-HSA-917720)	0.688	4
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.688	3
UniProt:Q9Y4H2 IRS2	4	IRS2 [cytosol] (R-HSA-57528) IRS2 [plasma membrane] (R-HSA-2428927) p-Y-IRS2 [cytosol] (R-HSA-74774) p-Y-IRS2 [plasma membrane] (R-HSA-198334)	0.688	3
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.688	3
UniProt:Q02241 KIF23	3	p-S904,S905-KIF23 [nucleoplasm] (R-HSA-156695) KIF23 [nucleoplasm] (R-HSA-156709) KIF23 [cytosol] (R-HSA-1015863)	0.688	3
UniProt:P19634 SLC9A1	1	SLC9A1 [plasma membrane] (R-HSA-426006)	0.678	4
UniProt:P30307 CDC25C	8	p-S191-CDC25C [nucleoplasm] (R-HSA-6802968) p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654) p-S198-CDC25C [cytosol] (R-HSA-8981697) p-S198-CDC25C [nucleoplasm] (R-HSA-156668) CDC25C [cytosol] (R-HSA-157879) p-S216-CDC25C [cytosol] (R-HSA-75003) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) CDC25C [nucleoplasm] (R-HSA-69741)	0.669	4
UniProt:Q53ET0 CRTC2	1	CRTC2 [nucleoplasm] (R-HSA-8931951)	0.669	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.667	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	11
UniProt:P54253 ATX1			0.666	4
UniProt:Q92934 BAD	4	BAD [cytosol] (R-HSA-50662) p-S99-BAD [cytosol] (R-HSA-198335) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S128-BAD [cytosol] (R-HSA-217297)	0.659	4
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S576 ARAF [plasma membrane] (R-HSA-5672648) p-S299,S302,T452,T455,S576 ARAF [cytosol] (R-HSA-5672646) p-S576 ARAF [cytosol] (R-HSA-5672681) p-S214,S576 ARAF [cytosol] (R-HSA-5672639)	0.643	6
UniProt:P56524 HDAC4	3	SUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) SUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) HDAC4 [nucleoplasm] (R-HSA-351581)	0.643	3
UniProt:P22681 CBL	39	CBL R420Q [cytosol] (R-HSA-9706186) CBL R420G [cytosol] (R-HSA-9706203) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL del366-409 [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637) CBL G375fs16 [cytosol] (R-HSA-9706211) CBL R420 [cytosol] (R-HSA-9706208) CBL H398D [cytosol] (R-HSA-9706631) CBL Y371C [cytosol] (R-HSA-9706694) CBL G375S [cytosol] (R-HSA-9706214) CBL Y371D [cytosol] (R-HSA-9706687) CBL Y371S [cytosol] (R-HSA-9706674) CBL P417S [cytosol] (R-HSA-9706642) CBL H398N [cytosol] (R-HSA-9706641) CBL R420P [cytosol] (R-HSA-9706193) CBL Y371N [cytosol] (R-HSA-9706679) CBL R499Q [cytosol] (R-HSA-9706677) CBL R420L [cytosol] (R-HSA-9706197) CBL P417H [cytosol] (R-HSA-9706644) p-Y371-CBL [cytosol] (R-HSA-182940) p-Y371-CBL [plasma membrane] (R-HSA-182923) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) p-Y-CBL [cytosol] (R-HSA-8875457) CBL [cytosol] (R-HSA-112199)	0.643	3
UniProt:Q02750 MAP2K1	27	MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) MAP2K1 Q56P [cytosol] (R-HSA-9652064) MAP2K1 E203K [cytosol] (R-HSA-9652023) MAP2K1 V60E [cytosol] (R-HSA-9652067) MAP2K1 P124S [cytosol] (R-HSA-9652062) MAP2K1 Y130C [cytosol] (R-HSA-9652101) MAP2K1 C121S [cytosol] (R-HSA-9652013) MAP2K1 G128V [cytosol] (R-HSA-9652047) MAP2K1 F53L [cytosol] (R-HSA-9652031) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 E44_E57del [cytosol] (R-HSA-9652026) MAP2K1 P124Q [cytosol] (R-HSA-9652058) MAP2K1 F53C [cytosol] (R-HSA-9652028) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) MAP2K1 [cytosol] (R-HSA-59502) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837)	0.643	4
UniProt:Q51451 Q51451			0.637	3
UniProt:Q61097	5	Ksr1 [cytosol] (R-MMU-5672587) phospho-Ksr1 [cytosol] (R-MMU-5672654) phospho-Ksr1 [cytosol] (R-MMU-5672652) phospho-Ksr1 [plasma membrane] (R-MMU-5672659) phospho-Ksr1 [cytosol] (R-MMU-5672656)	0.632	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.632	3
UniProt:Q15569 TESK1	1	TESK1 [cytosol] (R-HSA-446396)	0.611	4
UniProt:P55040 GEM			0.597	4
UniProt:P78362 SRPK2			0.59	2
UniProt:Q96JH8 RADIL			0.589	2
UniProt:Q9UJ41 RABGEF1	2	RABGEF1 [cytosol] (R-HSA-8875419) RABGEF1 [early endosome membrane] (R-HSA-2029032)	0.589	2
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.589	2
UniProt:Q96SB4 SRPK1			0.589	2
UniProt:Q9H0H5 RACGAP1	1	RACGAP1 [cytosol] (R-HSA-195122)	0.589	2
UniProt:O94915 FRYL			0.589	2
UniProt:Q8N3F8 MILK1			0.589	2
UniProt:Q96Q42 ALS2	1	ALS2 [cytosol] (R-HSA-8875298)	0.589	2
UniProt:Q86X29 LSR	1	LSR [plasma membrane] (R-HSA-8933138)	0.589	2
UniProt:Q9Y6M7 SLC4A7	1	SLC4A7 [plasma membrane] (R-HSA-425552)	0.589	2
UniProt:Q07866 KLC1	1	KLC1 [cytosol] (R-HSA-983284)	0.589	2
UniProt:Q9H4L5 OSBPL3	1	OSBPL3 [cytosol] (R-HSA-8867532)	0.589	2
UniProt:O75592 MYCB2			0.589	2
UniProt:Q99570 PIK3R4	2	PIK3R4 [cytosol] (R-HSA-188010) PIK3R4 [phagocytic vesicle membrane] (R-HSA-6798171)	0.589	2
UniProt:Q9UQ35 SRRM2	1	SRRM2 [nucleoplasm] (R-HSA-8865888)	0.589	2
UniProt:P33176 KIF5B	1	KIF5B [cytosol] (R-HSA-265181)	0.589	2
UniProt:Q6WCQ1 MPRIP	2	p-MPRIP-RAF1 fusion [cytosol] (R-HSA-6802540) MPRIP-RAF1 fusion [cytosol] (R-HSA-6802406)	0.589	2
UniProt:O75643 SNRNP200	1	SNRNP200 [nucleoplasm] (R-HSA-71885)	0.589	2
UniProt:Q9P0K7 RAI14			0.589	2
UniProt:Q9UDY2 TJP2	4	TJP2(?-?) [plasma membrane] (R-HSA-351897) TJP2 [plasma membrane] (R-HSA-351862) TJP2 [cytosol] (R-HSA-2064412) TJP2 [nucleoplasm] (R-HSA-2064410)	0.589	2
UniProt:Q9UKV3 ACIN1	3	ACIN1(1094-1341) [cytosol] (R-HSA-212516) ACIN1 [cytosol] (R-HSA-212519) ACIN1(1-1093) [cytosol] (R-HSA-212520)	0.589	2
UniProt:O94921 CDK14			0.581	5
UniProt:Q9NYF0 DACT1	1	DACT1 [cytosol] (R-HSA-4641144)	0.581	4
UniProt:P67828 KC1A			0.576	3
UniProt:P61588	1	Rnd3 [plasma membrane] (R-MMU-9696265)	0.576	5
UniProt:O14649 KCNK3	1	KCNK3 [plasma membrane] (R-HSA-1296326)	0.568	4
UniProt:Q9NSK0 KLC4	1	KLC4 [cytosol] (R-HSA-983244)	0.564	2
UniProt:Q5TCX8 M3K21			0.564	2
UniProt:Q92538 GBF1	2	GBF1 [cytosol] (R-HSA-6807751) GBF1 [Golgi membrane] (R-HSA-199994)	0.564	2
UniProt:O96013 PAK4	1	PAK4 [cytosol] (R-HSA-428461)	0.564	2
UniProt:Q7KZI7 MARK2			0.564	3
UniProt:Q99759 MAP3K3	1	MAP3K3 [cytosol] (R-HSA-507725)	0.564	2
UniProt:Q5PRF9 SMAG2			0.564	2
UniProt:Q86W92 PPFIBP1	1	PPFIBP1 [cytosol] (R-HSA-6799300)	0.564	2
UniProt:O43524 FOXO3	9	p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) FOXO3 [cytosol] (R-HSA-5687032) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) FOXO3 [nucleoplasm] (R-HSA-199305) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413)	0.564	3
UniProt:Q76353 Q76353			0.558	3
UniProt:Q9UQC2 GAB2	5	p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) p-Y-GAB2 [cytosol] (R-HSA-912529) GAB2 [cytosol] (R-HSA-508239) p-5Y-GAB2 [cytosol] (R-HSA-8855574) p-Y643-GAB2 [cytosol] (R-HSA-9677149)	0.558	4
UniProt:A0A0S2Z5Q7 A0A0S2Z5Q7			0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2
UniProt:P07228 ITGB1	1	Integrin beta-1 [plasma membrane] (R-GGA-2467444)	0.543	3
UniProt:Q6R327 RICTOR	1	RICTOR [cytosol] (R-HSA-198632)	0.527	2
UniProt:P55041 GEM			0.527	3
UniProt:Q91YE8 SYNP2			0.527	3
UniProt:Q8WUI4 HDAC7	1	HDAC7 [nucleoplasm] (R-HSA-3004534)	0.527	3
UniProt:P00519 ABL1	5	p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [nucleoplasm] (R-HSA-5686579) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610)	0.527	2
UniProt:B7UM99 TIR			0.527	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:O14654 IRS4	2	IRS4 [plasma membrane] (R-HSA-2424297) p-Y-IRS4 [plasma membrane] (R-HSA-2424302)	0.527	2
UniProt:Q8WYL5 SSH1			0.527	3
UniProt:P36507 MAP2K2	12	MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 V35M [cytosol] (R-HSA-9652086) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073) MAP2K2 Y134C [cytosol] (R-HSA-9652089)	0.527	3
UniProt:Q9UQL6 HDAC5	1	HDAC5 [nucleoplasm] (R-HSA-3004533)	0.527	2
UniProt:Q96B36 AKT1S1	5	p-S183,T246-AKT1S1 [cytosol] (R-HSA-5672863) AKT1S1 [nucleoplasm] (R-HSA-5083637) p-T246-AKT1S1 [cytosol] (R-HSA-377124) p-S183,T246-AKT1S1 [cytosol] (R-HSA-200163) AKT1S1 [cytosol] (R-HSA-200155)	0.527	2
UniProt:P55957 BID	4	MYS-BID(62-195) [cytosol] (R-HSA-141373) BID(62-195) [cytosol] (R-HSA-139953) MYS-BID(62-195) [mitochondrial outer membrane] (R-HSA-114266) BID(1-195) [cytosol] (R-HSA-50825)	0.524	2
UniProt:Q13627-2 DYRK1A			0.508	3
UniProt:Q11184	2	let-756 [extracellular region] (R-CEL-189856) let-756 [extracellular region] (R-CEL-189898)	0.508	2
UniProt:Q9P0K1-3 ADAM22			0.508	2
UniProt:O00257 CBX4	2	CBX4 [nucleoplasm] (R-HSA-389118) SUMO1-K494-CBX4 [nucleoplasm] (R-HSA-4551626)	0.499	2

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