APP(18-770) [extracellular region]

Stable Identifier
R-HSA-49335
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
APP, Amyloid beta A4 protein precursor, ABPP, Alzheimer's disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, Protease nexin-II, PN-II, APPI, PreA4, Soluble APP-alpha, S-APP- alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), Gamma-CTF(59), Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AID(59), Gamma-CTF(57), Gamma- secretase C-terminal fragment 57, Amyloid intracellular domain 57, AID(57), Gamma-CTF(50), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AID(50), C31
Icon
APP(18-770) [extracellular region] icon
APP(18-770) [extracellular region] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P05067 APP
Gene Names
APP, A4, AD1
Chain
signal peptide:1-17, chain:18-770, chain:18-687, chain:18-671, chain:18-286, chain:672-770, chain:672-713, chain:672-711, chain:688-770, peptide:688-713, peptide:688-711, chain:691-770, chain:712-770, chain:714-770, chain:721-770, chain:740-770
Reference Genes
BioGPS Gene:351 APP
COSMIC (genes):APP APP
CTD Gene:351 APP
dbSNP Gene:351 APP
ENSEMBL:ENSG00000142192 APP
HGNC:620 APP
KEGG Gene (Homo sapiens):351 APP
Monarch:351 APP
NCBI Gene:351 APP
OMIM:104760 APP
UCSC:P05067 APP
Reference Transcript
Other Identifiers
0001230601
11738008_s_at
11741216_x_at
11742210_a_at
11742211_x_at
11742215_s_at
11746866_a_at
11750384_a_at
11751350_a_at
11752199_a_at
11752200_x_at
11752481_a_at
11762804_x_at
16924551
200602_at
211277_3p_x_at
211277_x_at
214953_s_at
351
3927225
3927227
3927228
3927229
3927230
3927233
3927234
3927237
3927241
3927242
3927262
3927264
3927271
3927272
3927273
3927274
3927281
3927282
3927289
3927298
3927300
3927301
3927306
3927307
3927320
3927335
3927336
3927337
41136_s_at
64309_f_at
8069644
A_24_P314159
A_33_P3296479
A_33_P3508822
GE57419
GO:0000003
GO:0000278
GO:0000902
GO:0000978
GO:0001774
GO:0001934
GO:0001967
GO:0002265
GO:0002376
GO:0002576
GO:0003674
GO:0003677
GO:0004867
GO:0005102
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005635
GO:0005641
GO:0005737
GO:0005768
GO:0005769
GO:0005783
GO:0005788
GO:0005790
GO:0005791
GO:0005794
GO:0005796
GO:0005798
GO:0005829
GO:0005856
GO:0005886
GO:0005887
GO:0005905
GO:0005911
GO:0005929
GO:0005975
GO:0006091
GO:0006378
GO:0006397
GO:0006412
GO:0006417
GO:0006464
GO:0006468
GO:0006629
GO:0006810
GO:0006878
GO:0006897
GO:0006915
GO:0006950
GO:0006979
GO:0007049
GO:0007155
GO:0007165
GO:0007176
GO:0007186
GO:0007219
GO:0007267
GO:0007399
GO:0007409
GO:0007568
GO:0007611
GO:0007612
GO:0007617
GO:0007626
GO:0008021
GO:0008088
GO:0008150
GO:0008201
GO:0008203
GO:0008219
GO:0008283
GO:0008285
GO:0008344
GO:0008542
GO:0009056
GO:0009058
GO:0009314
GO:0009986
GO:0009987
GO:0010288
GO:0010466
GO:0010468
GO:0010628
GO:0010629
GO:0010800
GO:0010951
GO:0010952
GO:0010971
GO:0014005
GO:0016020
GO:0016021
GO:0016192
GO:0016199
GO:0016322
GO:0016358
GO:0016504
GO:0019899
GO:0021700
GO:0022607
GO:0030111
GO:0030134
GO:0030154
GO:0030198
GO:0030234
GO:0030414
GO:0030424
GO:0030426
GO:0030546
GO:0030705
GO:0030900
GO:0031093
GO:0031175
GO:0031410
GO:0031594
GO:0031904
GO:0032092
GO:0032588
GO:0032640
GO:0032991
GO:0033138
GO:0034641
GO:0035235
GO:0035253
GO:0040007
GO:0040011
GO:0040014
GO:0042327
GO:0042535
GO:0042592
GO:0042802
GO:0042995
GO:0043005
GO:0043167
GO:0043197
GO:0043198
GO:0043204
GO:0043226
GO:0043235
GO:0043393
GO:0043687
GO:0044267
GO:0044281
GO:0044304
GO:0045080
GO:0045087
GO:0045121
GO:0045177
GO:0045202
GO:0045410
GO:0045665
GO:0045821
GO:0045931
GO:0045944
GO:0046330
GO:0046872
GO:0046914
GO:0048143
GO:0048169
GO:0048471
GO:0048669
GO:0048786
GO:0048856
GO:0048870
GO:0050725
GO:0050730
GO:0050803
GO:0050808
GO:0050877
GO:0050885
GO:0050890
GO:0051091
GO:0051092
GO:0051124
GO:0051233
GO:0051247
GO:0051402
GO:0051425
GO:0051563
GO:0055037
GO:0055085
GO:0070062
GO:0070374
GO:0070555
GO:0070851
GO:0071280
GO:0071287
GO:0071320
GO:0071874
GO:0090647
GO:0097449
GO:0098815
GO:0150003
GO:1900272
GO:1900273
GO:1901224
GO:1902004
GO:1904646
GO:1905606
GO:1905908
GO:1990000
GO:1990090
GO:1990535
GO:1990761
GO:1990812
GO:2000310
GO:2000406
Hs.177486.2.A1_3p_a_at
ILMN_1653283
ILMN_1678152
ILMN_2404063
ILMN_2404065
PH_hs_0010546
TC21000340.hg
TC21000887.hg
Y00264_at
g4502166_3p_at
Participant Of
hasMember
Other forms of this molecule
APP(18-770) [trans-Golgi network membrane]
APP-C99 [cytosol]
APP(18-687) [extracellular region]
APP(688-770) [plasma membrane]
APP(18-770) [Golgi lumen]
APP(18-770) [plasma membrane]
APP(18-671) [endosome lumen]
APP(714-770) [endosome lumen]
APP(712-770) [endosome lumen]
APP(672-770) [endosome lumen]
APP(672-713) [endosome lumen]
APP(672-711) [endosome lumen]
APP(18-770) [endosome lumen]
APP(18-770) [platelet alpha granule lumen]
APP(672-711) [cytosol]
APP(672-711) [extracellular region]
p-APP [endoplasmic reticulum lumen]
APP [endoplasmic reticulum lumen]
APP(672-713) [extracellular region]
Inferred To
App [extracellular region] (Mus musculus)
App [extracellular region] (Rattus norvegicus)
Appl [extracellular region] (Drosophila melanogaster)
app [extracellular region] (Xenopus tropicalis)
appb [extracellular region] (Danio rerio)
apl-1 [extracellular region] (Caenorhabditis elegans)
APP [extracellular region] (Gallus gallus)
Cross References
RefSeq
OpenTargets
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
1X11, 2MPZ, 5CSZ, 2IPU, 1QCM, 1AMC, 4MVK, 3BAE, 3BKJ, 3OVJ, 2LZ3, 1BA4, 6IYC, 4JFN, 2LP1, 3IFO, 2FMA, 2OTK, 1AML, 3MXC, 2LNQ, 1UO8, 5HOY, 5AEF, 5MY4, 2Y3K, 2FK3, 1OWT, 5ONQ, 4HIX, 1QWP, 5BUO, 2LMN, 2M9R, 3SV1, 2MVX, 4PWQ, 2R0W, 5HOW, 2FKL, 5VZY, 1QYT, 3JTI, 2LZ4, 3JQ5, 1Z0Q, 2M4J, 4M1C, 5W3P, 3UMH, 1ZE9, 5AM8, 5LV0, 1BJC, 3IFP, 1BRC, 2LFM, 1QXC, 4MDR, 5KK3, 6GFI, 3GCI, 3OW9, 3DXC, 2Y3L, 4MVL, 3L81, 2LMO, 2BOM, 6CO3, 5VOS, 1CA0, 2M9S, 3MXY, 2MXU, 4NGE, 3L33, 3IFL, 2LMP, 1AMB, 1ZJD, 2BP4, 2G47, 2NAO, 1HZ3, 6NB9, 3U0T, 1BJB, 3AYU, 3UMI, 3PZZ, 1TKN, 1BA6, 6OC9, 3NYL, 5MYX, 6ITU, 3DXD, 4XXD, 1UOA, 1IYT, 4ONF, 5C67, 6SHS, 2FJZ, 5ONP, 1UOI, 2Y29, 1TAW, 2BEG, 5AMB, 3IFN, 5OQV, 2LOH, 1ZE7, 2LMQ, 4PQD, 4MVI, 5LFY, 3KTM, 3UMK, 3Q2X, 2LLM, 1UO7, 2MGT, 6RHY, 4OJF, 2WK3, 2FK1, 1AAP, 4ONG, 3DXE, 3MOQ, 3NYJ, 2Y3J, 5HOX, 1MWP, 2MJ1, 2Y2A, 2FK2, 5MYO, 5TXD, 6O4J, 3JQL
HPA
GeneCards
Ensembl
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (42)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P05067 APP  20 0.993 106
 UniProt:O00213 APBB1  1 0.839 7
 UniProt:P56817 BACE1  8 0.797 8
 UniProt:Q9UQF2 JIP1      0.72 5
 UniProt:P61812 TGFB2  3 0.718 7
 UniProt:Q02410 APBA1  1 0.646 4
 UniProt:P04156 PRNP  2 0.641 3
 UniProt:P01137 TGFB1  6 0.641 3
 UniProt:Q92870 APBB2      0.635 3
 UniProt:P49768 PSEN1  6 0.632 6
 UniProt:P10636 MAPT  3 0.632 5
 UniProt:Q99714 HSD17B10  1 0.625 4
 UniProt:P02647 APOA1  11 0.625 5
 UniProt:O35431 Apba2  1 0.618 5
 UniProt:P42704 LRPPRC  1 0.612 8
 UniProt:Q99767 APBA2  1 0.592 2
 UniProt:Q9NP59 SLC40A1  7 0.589 5
 UniProt:P29353 SHC1  5 0.589 6
 UniProt:O75955 FLOT1  1 0.581 5
 UniProt:Q13625 TP53BP2  1 0.581 3
 UniProt:P07196 NEFL  1 0.564 2
 UniProt:P27797 CALR  6 0.564 2
 UniProt:Q99683 MAP3K5  1 0.564 2
 UniProt:P08138 NGFR  7 0.558 2
 UniProt:O95704 APBB3      0.553 2
 UniProt:P00533 EGFR  59 0.553 2
 UniProt:O60293 ZC3H1      0.547 2
 UniProt:Q306T3 Q306T3      0.544 3
 UniProt:P15253 CALR      0.544 3
 UniProt:P46933  1 0.528 2
 UniProt:P61457 PCBD1  1 0.524 2
 UniProt:P01100 FOS  2 0.524 3
 UniProt:Q9CR16  1 0.508 3
 UniProt:P21359 NF1  37 0.508 3
 UniProt:P78352 DLG4  3 0.499 2
 UniProt:P30101 PDIA3  3 0.499 3
 UniProt:P56817-1 BACE1      0.489 2
 UniProt:O14879 IFIT3  1 0.482 2
 UniProt:Q92673 SORL1  2 0.463 2
 UniProt:P04578 env  7 0.462 2
 UniProt:Q15392 DHCR24  1 0.462 3
 UniProt:Q99720 SIGMAR1  1 0.462 3
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