Reactome | AMPD2 [cytosol]

AMPD2 [cytosol]

Stable Identifier

R-HSA-49927

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AMP deaminase isoform L, AMP deaminase 2, AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L)

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
7287721	Platelet AMP deaminase. Purification and kinetic studies. Holmsen, H	J Biol Chem	1981
	The Metabolic and Molecular Bases of Inherited Disease, 8th ed Scriver, CR, Beaudet, AL, Valle, D, Sly, WS		2001

External Reference Information

External Reference

UniProt:Q01433 AMPD2

Gene Names

AMPD2

Chain

chain:1-825

Reference Genes

BioGPS Gene:271 AMPD2

COSMIC (genes):AMPD2 AMPD2

CTD Gene:271 AMPD2

dbSNP Gene:271 AMPD2

ENSEMBL:ENSG00000116337 AMPD2

HGNC:469 AMPD2

KEGG:hsa:271 AMPD2

Monarch:271 AMPD2

NCBI Gene:271 AMPD2

OMIM:102771 AMPD2

UCSC:Q01433 AMPD2

Reference Transcript

Other Identifiers

11724224_a_at

11730829_a_at

11730830_x_at

11745744_a_at

16668288

212360_PM_at

212360_at

2350879

2350881

2350882

2350883

2350884

2350885

2350886

2350887

2350889

2350890

2350891

2350892

2350893

2350894

2350895

2350896

2350897

2350898

2350899

2350900

2350901

2350902

2350903

2350904

2350905

2350906

2350907

2350908

2350909

2350910

2350911

2350912

2350913

2350914

271

38417_at

58014_at

7903719

A_23_P201596

GE58134

GE883000

GO:0003876

GO:0005515

GO:0005829

GO:0006188

GO:0006753

GO:0009117

GO:0009168

GO:0016787

GO:0019239

GO:0032264

GO:0042632

GO:0042802

GO:0046033

GO:0046034

GO:0046039

GO:0046872

GO:0048856

GO:0052652

GO:0055086

GO:0072015

GO:0097009

GO:1901135

HMNXSV003024033

HMNXSV003057632

Hs.82927.0.S2_3p_at

ILMN_1696830

ILMN_1701589

ILMN_1786899

M91029_cds2_at

PH_hs_0004744

TC01000950.hg

TC01004607.hg

Participates

as a component of

AMPD2 tetramer [cytosol] (Homo sapiens)

Inferred To

ada1 [cytosol] (Schizosaccharomyces pombe)

amdA [cytosol] (Dictyostelium discoideum)

AMPdeam [cytosol] (Drosophila melanogaster)

Ampd2 [cytosol] (Mus musculus)

Ampd2 [cytosol] (Rattus norvegicus)

AMD1 [cytosol] (Saccharomyces cerevisiae)

ampd-1 [cytosol] (Caenorhabditis elegans)

AMPD2 [cytosol] (Bos taurus)

AMPD2 [cytosol] (Canis familiaris)

AMPD2 [cytosol] (Gallus gallus)

AMPD2 [cytosol] (Plasmodium falciparum)

AMPD2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_631895.1, NP_981949.1, NP_004028.3, NP_001355738.1, NP_001295099.1, NP_001244290.1, NP_001244289.1

OpenTargets

ENSG00000116337

ENSEMBL

ENST00000528667, ENST00000528454, ENSP00000437164, ENST00000342115, ENST00000531203, ENST00000256578, ENST00000531734, ENSP00000433739, ENSG00000116337, ENSP00000431975, ENSP00000256578, ENSP00000345498, ENSP00000436541

ZINC - Substances

AMPD2_HUMAN

ZINC target

Q01433

PRO

Q01433

GlyGen

Q01433

PDB

8HUB, 8HU6, 4NO5, 4NO3

HPA

ENSG00000116337-AMPD2

GeneCards

AMPD2

Pharos - Targets

Q01433

Orphanet

AMPD2

ZINC - Predictions - Purchasable

AMPD2_HUMAN

HMDB Protein

HMDBP00599

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18827 SDC1	20	HS(4)-SDC1 [plasma membrane] (R-HSA-2076693) HS(6)-SDC1 [plasma membrane] (R-HSA-2076652) HS(2)-SDC1 [plasma membrane] (R-HSA-2076666) HS(1)-SDC1 [plasma membrane] (R-HSA-2076672) HS(3)-SDC1 [plasma membrane] (R-HSA-2076691) HS(5)-SDC1 [plasma membrane] (R-HSA-2076626) SDC1 [plasma membrane] (R-HSA-174758) Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064148) Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064247) XylS-SDC1 [Golgi lumen] (R-HSA-2064146) SDC1 [Golgi lumen] (R-HSA-2054105) GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064082) HS(5)-SDC1 [Golgi lumen] (R-HSA-2076290) HS(6)-SDC1 [Golgi lumen] (R-HSA-2076520) HS(4)-SDC1 [Golgi lumen] (R-HSA-2076593) HS(3)-SDC1 [Golgi lumen] (R-HSA-2076444) HS(2)-SDC1 [Golgi lumen] (R-HSA-2076309) HS(1)-SDC1 [Golgi lumen] (R-HSA-2076321) Heparan(4)-SDC1 [Golgi lumen] (R-HSA-2076339) Heparan(3)-SDC1 [Golgi lumen] (R-HSA-2076314)	0.669	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.643	3
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) SDC2 [Golgi lumen] (R-HSA-2054101) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607)	0.643	4
UniProt:P16070 CD44	2	CD44 [plasma membrane] (R-HSA-1031688) CD44 [secretory granule membrane] (R-HSA-6804776)	0.527	2
UniProt:Q9UPP1 PHF8	1	PHF8 [nucleoplasm] (R-HSA-5423096)	0.527	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	2

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