Reactome | LIN28A [cytosol]

LIN28A [cytosol]

Stable Identifier

R-HSA-500391

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Lin-28 homolog A, LN28A_HUMAN, LIN28

Locations in the PathwayBrowser for interactor UniProt:Q9Y4C8 RBM19

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External Reference Information

External Reference

UniProt:Q9H9Z2 LIN28A

Gene Names

LIN28A, CSDD1, LIN28, ZCCHC1

Chain

initiator methionine:, chain:2-209

Reference Genes

BioGPS Gene:79727 LIN28A

COSMIC (genes):LIN28A LIN28A

CTD Gene:79727 LIN28A

dbSNP Gene:79727 LIN28A

ENSEMBL:ENSG00000131914 LIN28A

HGNC:15986 LIN28A

KEGG:hsa:79727 LIN28A

Monarch:79727 LIN28A

NCBI Gene:79727 LIN28A

OMIM:611043 LIN28A

UCSC:Q9H9Z2 LIN28A

Reference Transcript

Other Identifiers

11725430_at

16661155

219823_PM_at

219823_at

2326486

2326487

2326489

2326490

2326491

2326492

2326493

2326494

2326495

2326497

2326498

2326499

2326500

2326501

2326502

2518805

3371883

62956_at

7899167

79727

91330_at

A_23_P74895

GE86917

GE88684

GO:0000932

GO:0002151

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005730

GO:0005737

GO:0005783

GO:0005791

GO:0005829

GO:0007281

GO:0008270

GO:0010494

GO:0010586

GO:0010587

GO:0010629

GO:0017148

GO:0019827

GO:0022414

GO:0030154

GO:0031047

GO:0031054

GO:0031123

GO:0031369

GO:0032008

GO:0035198

GO:0043226

GO:0045666

GO:0045686

GO:0045727

GO:0048856

GO:0048863

GO:0051897

GO:0060090

GO:0060964

GO:0070883

GO:0071076

GO:0071333

GO:0140517

GO:1901724

GO:1990825

GO:2000632

GO:2000767

HMNXSV003054545

ILMN_1748903

PH_hs_0004853

TC01000343.hg

g13375937_3p_at

Participates

as an input of

LIN28 binds POU5F1 (OCT4) mRNA (Homo sapiens)

as a component of

LIN28:POU5F1 mRNA [cytosol] (Homo sapiens)

Inferred To

LIN28A [cytosol] (Bos taurus)

LIN28A [cytosol] (Canis familiaris)

LIN28A [cytosol] (Gallus gallus)

LIN28A [cytosol] (Sus scrofa)

Lin28a [cytosol] (Mus musculus)

Lin28a [cytosol] (Rattus norvegicus)

lin-28 [cytosol] (Caenorhabditis elegans)

lin-28 [cytosol] (Drosophila melanogaster)

lin28a [cytosol] (Danio rerio)

lin28a [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_078950.1, XP_011540450.1, XP_054194727.1

OpenTargets

ENSG00000131914

ENSEMBL

ENSP00000363314, ENST00000254231, ENSP00000254231, ENSG00000131914, ENST00000326279

GeneCards

LIN28A

HPA

ENSG00000131914-LIN28A

PRO

Q9H9Z2

Pharos - Targets

Q9H9Z2

GlyGen

Q9H9Z2

HMDB Protein

HMDBP10913

PDB

8OST, 8OPS, 2LI8, 2CQF, 5UDZ, 8OPT

Interactors (158)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.725	4
UniProt:O00425 IGF2BP3	1	IGF2BP3 [cytosol] (R-HSA-428313)	0.643	3
UniProt:Q8IWX8 CHERP	1	CHERP [nucleoplasm] (R-HSA-8865901)	0.643	4
UniProt:Q9BVI4 NOC4L	1	NOC4L [nucleoplasm] (R-HSA-6790616)	0.643	4
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.643	4
UniProt:Q9NUL7 DDX28			0.643	3
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [extracellular region] (R-HSA-9017791) YBX1 [nucleoplasm] (R-HSA-72041)	0.643	4
UniProt:Q9H6S0 YTHDC2	1	YTHDC2 [nucleoplasm] (R-HSA-9935827)	0.643	3
UniProt:Q9NUD5 ZCHC3			0.643	4
UniProt:Q6ZN17 LN28B			0.643	4
UniProt:Q5VWQ0 RSBN1			0.643	4
UniProt:P62899 RPL31	1	RPL31 [cytosol] (R-HSA-72454)	0.643	4
UniProt:Q9H7E9 CH033			0.643	4
UniProt:Q5TAX3 ZCCHC11	1	TUT4 [cytosol] (R-HSA-8941307)	0.558	2
UniProt:Q9NSD4 ZN275			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	18
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:O15371 EIF3D	1	EIF3D [cytosol] (R-HSA-72548)	0.547	5
UniProt:O76021 RL1D1			0.527	2
UniProt:P16403 H1-2	1	HIST1H1C [nucleoplasm] (R-HSA-211237)	0.527	2
UniProt:P82673 MRPS35	1	MRPS35 [mitochondrial inner membrane] (R-HSA-5368185)	0.527	2
UniProt:Q9HCE1 MOV10	1	MOV10 [cytosol] (R-HSA-427772)	0.527	3
UniProt:Q96JP5 ZFP91			0.527	2
UniProt:Q9BV44 THUM3			0.527	2
UniProt:Q8N5C6 SRBD1			0.527	2
UniProt:P68363 TUBA1B	9	TUBA1B [cytosol] (R-HSA-191691) TUBA1B [axonemal microtubule] (R-HSA-5610434) TUBA1B(1-450) [cytosol] (R-HSA-8955581) Polyglutamyl-TUBA1B [cytosol] (R-HSA-8867435) L-isoglutamyl polyglycyl-TUBA1B [cytosol] (R-HSA-8867436) TUBA1B unfolded [cytosol] (R-HSA-392781) TUBA1B folding intermediate [cytosol] (R-HSA-392797) Ac K40 TUBA1B [axonemal microtubule] (R-HSA-5624854) AcK-TUBA1B [cytosol] (R-HSA-5618285)	0.527	2
UniProt:Q8N9T8 KRI1			0.527	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	2
UniProt:Q7Z2W4 ZC3HAV1	2	ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol] (R-HSA-6802506) ZC3HAV1(2-624)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802557)	0.527	3
UniProt:Q99848 EBNA1BP2	1	EBNA1BP2 [nucleoplasm] (R-HSA-8869325)	0.527	2
UniProt:Q9BZE4 GTPB4			0.527	2
UniProt:Q9H2U1 DHX36	1	DHX36 [cytosol] (R-HSA-3134862)	0.527	2
UniProt:Q9Y3D3 MRPS16	1	MRPS16 [mitochondrial inner membrane] (R-HSA-5368229)	0.527	2
UniProt:Q1ED39 KNOP1			0.527	2
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.527	2
UniProt:O96028 NSD2	2	WHSC1 [nucleoplasm] (R-HSA-1183215) p-S102-WHSC1 [nucleoplasm] (R-HSA-5682984)	0.527	2
UniProt:Q9H8H2 DDX31			0.527	2
UniProt:Q13823 NOG2			0.527	2
UniProt:Q16777 H2AC20	13	HIST2H2AC [nucleoplasm] (R-HSA-181892) AcK-HIST2H2AC [nucleoplasm] (R-HSA-4551338) HIST2H2AC [extracellular region] (R-HSA-977563) MeR12-HIST2H2AC [nucleoplasm] (R-HSA-5229227) Me2aR12-HIST2H2AC [nucleoplasm] (R-HSA-5229306) Me2sR4-HIST2H2AC [nucleoplasm] (R-HSA-5218305) MeR4-HIST2H2AC [nucleoplasm] (R-HSA-5244625) Me2aR4-HIST2H2AC [nucleoplasm] (R-HSA-5244589) MeR30-HIST2H2AC [nucleoplasm] (R-HSA-5244542) Me2aR30-HIST2H2AC [nucleoplasm] (R-HSA-5244562) AcK6-HIST2H2AC [nucleoplasm] (R-HSA-4568572) Ub-HIST2H2AC [nucleoplasm] (R-HSA-6782532) K63polyUb-HIST2H2AC [nucleoplasm] (R-HSA-6783299)	0.527	3
UniProt:Q9UPY3 DICER1	1	DICER1 [cytosol] (R-HSA-203820)	0.527	2
UniProt:Q8IV48 ERI1	1	ERI1 [nucleoplasm] (R-HSA-8878863)	0.527	2
UniProt:Q8IX01 SUGP2			0.527	2
UniProt:Q9ULW3 ABT1			0.527	2
UniProt:Q14692 BMS1	1	BMS1 [nucleoplasm] (R-HSA-6790720)	0.527	2
UniProt:P61313 RPL15	1	RPL15 [cytosol] (R-HSA-72416)	0.527	3
UniProt:Q9Y4C8 RBM19			0.527	3
UniProt:Q14690 PDCD11	1	PDCD11 [nucleoplasm] (R-HSA-6790646)	0.527	2
UniProt:Q2Q1W2 TRIM71	1	TRIM71 [cytosol] (R-HSA-5688972)	0.527	2
UniProt:Q9BRJ6 CHOLN			0.527	2
UniProt:P60866 RPS20	2	RPS20 [cytosol] (R-HSA-72349) RPS20 [nucleoplasm] (R-HSA-6798727)	0.527	2
UniProt:Q14684 RRP1B			0.527	2
UniProt:Q5JTH9 RRP12			0.527	2
UniProt:Q9Y3B9 RRP15			0.527	2
UniProt:P62750 RPL23A	1	RPL23A [cytosol] (R-HSA-72432)	0.527	2
UniProt:Q6P158 DHX57			0.527	3
UniProt:P42766 RPL35	1	RPL35 [cytosol] (R-HSA-72460)	0.527	3
UniProt:Q96GA3 LTV1	2	LTV1 [nucleoplasm] (R-HSA-6791566) LTV1 [cytosol] (R-HSA-6791520)	0.527	2
UniProt:Q15397 PUM3			0.527	2
UniProt:Q02878 RPL6	1	RPL6 [cytosol] (R-HSA-72484)	0.527	3
UniProt:O76094 SRP72	1	SRP72 [cytosol] (R-HSA-265069)	0.527	3
UniProt:Q9Y3B7 MRPL11	1	MRPL11 [mitochondrial inner membrane] (R-HSA-5368251)	0.527	2
UniProt:O75569 PRKRA	2	PRKRA [cytosol] (R-HSA-2399897) p-S246,S287-PRKRA [cytosol] (R-HSA-9834791)	0.527	2
UniProt:Q96MU7 YTHDC1	1	YTHDC1 [nucleoplasm] (R-HSA-9935812)	0.527	2
UniProt:O95793 STAU1			0.527	3
UniProt:Q00577 PURA			0.527	2
UniProt:Q9NYV4 CDK12	1	CDK12 [nucleoplasm] (R-HSA-6797012)	0.527	2
UniProt:Q9NVP1 DDX18			0.527	2
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.527	2
UniProt:Q8TDN6 BRX1			0.527	2
UniProt:P32969 RPL9	1	RPL9 [cytosol] (R-HSA-72492)	0.527	2
UniProt:Q53F19 NCBP3			0.527	2
UniProt:Q9P1Y6 PHRF1			0.527	2
UniProt:Q96KR1 ZFR			0.527	3
UniProt:O15234 CASC3	2	CASC3 [cytosol] (R-HSA-927807) CASC3 [nucleoplasm] (R-HSA-8849148)	0.527	2
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.527	3
UniProt:Q49A26 GLYR1			0.527	3
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.527	2
UniProt:Q96ME7 ZN512			0.527	2
UniProt:Q13243 SRSF5	1	SRSF5 [nucleoplasm] (R-HSA-72028)	0.527	2
UniProt:P62917 RPL8	3	RPL8 [cytosol] (R-HSA-72490) RPL8 [nucleoplasm] (R-HSA-9630985) 3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976)	0.527	2
UniProt:Q96QR8 PURB			0.527	3
UniProt:O75494 SRSF10	1	SRSF10 [nucleoplasm] (R-HSA-8866646)	0.527	2
UniProt:Q9BTD8 RBM42	1	RBM42 [nucleoplasm] (R-HSA-9769526)	0.527	2
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.527	2
UniProt:O60832 DKC1	1	DKC1 [nucleoplasm] (R-HSA-163102)	0.527	3
UniProt:Q99755 PIP5K1A	1	PIP5K1A [cytosol] (R-HSA-1806260)	0.527	2
UniProt:P18621 RPL17	1	RPL17 [cytosol] (R-HSA-72418)	0.527	3
UniProt:Q8WXA9 SREK1			0.527	3
UniProt:Q9UPT8 ZC3H4	1	ZC3H4 [nucleoplasm] (R-HSA-9930063)	0.527	2
UniProt:O75934 BCAS2	1	BCAS2 [nucleoplasm] (R-HSA-5420902)	0.527	2
UniProt:O15226 NKRF			0.527	2
UniProt:P05387 RPLP2	1	RPLP2 [cytosol] (R-HSA-72400)	0.527	2
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.527	2
UniProt:Q9Y520 PRC2C			0.527	2
UniProt:Q8N5P1 ZC3H8	1	ZC3H8 [nucleoplasm] (R-HSA-6807406)	0.527	3
UniProt:P62906 RPL10A	1	RPL10A [cytosol] (R-HSA-72404)	0.527	2
UniProt:Q9NUL3 STAU2			0.527	2
UniProt:P62854 RPS26	2	RPS26 [cytosol] (R-HSA-72359) RPS26 [nucleoplasm] (R-HSA-6798708)	0.527	2
UniProt:P61247 RPS3A	2	RPS3A [cytosol] (R-HSA-72373) RPS3A [nucleoplasm] (R-HSA-6791182)	0.527	2
UniProt:P0C0S8 H2AC11	11	Ack-HIST1H2AG [nucleoplasm] (R-HSA-4551311) HIST1H2AG [nucleoplasm] (R-HSA-212084) MeR12-HIST1H2AG [nucleoplasm] (R-HSA-5229206) Me2aR12-HIST1H2AG [nucleoplasm] (R-HSA-5229305) MeR4-HIST1H2AG [nucleoplasm] (R-HSA-5244623) Me2aR4-HIST1H2AG [nucleoplasm] (R-HSA-5244587) MeR30-HIST1H2AG [nucleoplasm] (R-HSA-5244560) Me2aR30-HIST1H2AG [nucleoplasm] (R-HSA-5244582) Ack6-HIST1H2AG [nucleoplasm] (R-HSA-4568595) Ub-HIST1H2AG [nucleoplasm] (R-HSA-6782508) K63polyUb-HIST1H2AG [nucleoplasm] (R-HSA-6783237)	0.527	2
UniProt:Q8TDD1 DDX54			0.527	2
UniProt:Q96I25 RBM17	1	RBM17 [nucleoplasm] (R-HSA-8865891)	0.527	2
UniProt:P08708 RPS17	2	RPS17 [cytosol] (R-HSA-72339) RPS17 [nucleoplasm] (R-HSA-6798719)	0.527	3
UniProt:P46783 RPS10	2	RPS10 [cytosol] (R-HSA-72325) RPS10 [nucleoplasm] (R-HSA-6798733)	0.527	3
UniProt:Q9HD33 MRPL47	1	MRPL47 [mitochondrial inner membrane] (R-HSA-5368180)	0.527	3
UniProt:Q9GZR7 DDX24			0.527	3
UniProt:Q9BYG3 MK67I			0.527	2
UniProt:P47914 RPL29	1	RPL29 [cytosol] (R-HSA-72446)	0.527	2
UniProt:Q9UNQ2 DIMT1	1	DIMT1 [nucleoplasm] (R-HSA-6791001)	0.527	2
UniProt:Q9BYD3 MRPL4	1	MRPL4 [mitochondrial inner membrane] (R-HSA-5368212)	0.527	3
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.527	2
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	2
UniProt:Q92665 MRPS31	1	MRPS31 [mitochondrial inner membrane] (R-HSA-5368198)	0.527	2
UniProt:P62841 RPS15	2	RPS15 [cytosol] (R-HSA-72335) RPS15 [nucleoplasm] (R-HSA-6798706)	0.527	3
UniProt:P82930 MRPS34	1	MRPS34 [mitochondrial inner membrane] (R-HSA-5368186)	0.527	2
UniProt:Q7L2E3 DHX30			0.527	2
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.527	2
UniProt:Q99575 POP1	1	POP1 [nucleoplasm] (R-HSA-5696802)	0.527	2
UniProt:P19338 NCL	3	NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.527	2
UniProt:Q9NUQ6 SPS2L			0.527	2
UniProt:P16989 YBOX3			0.527	2
UniProt:Q9BQ39 DDX50			0.527	2
UniProt:Q96EY7 PTCD3	1	PTCD3 [mitochondrial inner membrane] (R-HSA-5368165)	0.527	2
UniProt:Q9H0A0 NAT10	1	NAT10 [nucleoplasm] (R-HSA-6791008)	0.527	2
UniProt:Q9P015 MRPL15	1	MRPL15 [mitochondrial inner membrane] (R-HSA-5368193)	0.527	3
UniProt:Q13310 PABP4			0.527	3
UniProt:P62847 RPS24	2	RPS24 [cytosol] (R-HSA-72355) RPS24 [nucleoplasm] (R-HSA-6791186)	0.527	2
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.527	2
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.527	2
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	3
UniProt:P62277 RPS13	2	RPS13 [cytosol] (R-HSA-72331) RPS13 [nucleoplasm] (R-HSA-6791198)	0.527	3
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.527	4
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.527	2
UniProt:Q13601 KRR1	1	KRR1 [nucleoplasm] (R-HSA-6790611)	0.527	3
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.527	3
UniProt:Q8N567 ZCHC9			0.527	2
UniProt:P05455 SSB	1	SSB [nucleoplasm] (R-HSA-58418)	0.527	3
UniProt:Q9NXG2 THUMPD1	1	THUMPD1 [nucleoplasm] (R-HSA-6791004)	0.527	3
UniProt:Q71RC2 LARP4			0.527	2
UniProt:Q9BXS6 NUSAP			0.527	2
UniProt:P51398 DAP3	1	DAP3 [mitochondrial inner membrane] (R-HSA-5368174)	0.527	2
UniProt:Q13206 DDX10			0.527	2
UniProt:Q6ZN55 ZN574			0.527	2
UniProt:O15042 U2SURP	1	U2SURP [nucleoplasm] (R-HSA-8865950)	0.527	3
UniProt:Q5VYS8 ZCCHC6	1	TUT7 [cytosol] (R-HSA-8941313)	0.527	2
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	2
UniProt:Q9NV31 IMP3	1	IMP3 [nucleoplasm] (R-HSA-6790664)	0.527	2
UniProt:Q9NY93 DDX56			0.527	2
UniProt:Q92552 MRPS27	1	MRPS27 [mitochondrial inner membrane] (R-HSA-5368214)	0.527	2
UniProt:Q9NZB2 F120A			0.527	2
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.527	3
UniProt:P82933 MRPS9	1	MRPS9 [mitochondrial inner membrane] (R-HSA-5368194)	0.527	2
IntAct:EBI-2462028 PRE-LET-7A			0.525	3
UniProt:Q15029 EFTUD2	1	EFTUD2 [nucleoplasm] (R-HSA-71883)	0.504	4
UniProt:Q86X55 CARM1	1	CARM1 [nucleoplasm] (R-HSA-400139)	0.462	3
UniProt:Q9Y3I0 RTCB	1	RTCB [nucleoplasm] (R-HSA-5696792)	0.462	3
UniProt:Q15393 SF3B3	1	SF3B3 [nucleoplasm] (R-HSA-71973)	0.462	3

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