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APAF1 [cytosol]
Stable Identifier
R-HSA-50099
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Apaf-1, Apoptotic protease activating factor 1
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
APAF1 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
TP53 stimulates APAF1 gene expression (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Apoptotic factor-mediated response (Homo sapiens)
Cytochrome c-mediated apoptotic response (Homo sapiens)
Activation of caspases through apoptosome-mediated cleavage (Homo sapiens)
Cleavage of Procaspase-3 by the apoptosome (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
Cleavage of Procaspase-7 by the apoptosome (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
Formation of apoptosome (Homo sapiens)
CYCS binds to APAF1 (Homo sapiens)
APAF1:ADP [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
APAF1:ATP:CYCS [cytosol] (Homo sapiens)
APAF1:ATP [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
CYCS:APAF1 binds procaspase-9 (Homo sapiens)
APAF1:ATP:CYCS [cytosol] (Homo sapiens)
APAF1:ATP [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Homo sapiens)
APAF1:ATP:CYCS [cytosol] (Homo sapiens)
APAF1:ATP [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
Cleavage of Procaspase‑9 to caspase‑9 (Homo sapiens)
APAF1:CYCS:ATP:CASP9(1-416)dimer [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
Procaspase 9 forms dimer (Homo sapiens)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Homo sapiens)
APAF1:ATP:CYCS [cytosol] (Homo sapiens)
APAF1:ATP [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
APAF1:CYCS:ATP:CASP9(1-416)dimer [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
Regulation of the apoptosome activity (Homo sapiens)
APAF1 binds AVEN (Homo sapiens)
APAF1:ADP [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
APAF1:AVEN [cytosol] (Homo sapiens)
APAF1:ADP [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
APAF1:CYCS binds APIP (Homo sapiens)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Homo sapiens)
APAF1:ATP:CYCS [cytosol] (Homo sapiens)
APAF1:ATP [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
APAF1:CYCS:ATP:APIP [cytosol] (Homo sapiens)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Homo sapiens)
APAF1:ATP:CYCS [cytosol] (Homo sapiens)
APAF1:ATP [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
CASP9 is phosphorylated at T125 (Homo sapiens)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Homo sapiens)
APAF1:ATP:CYCS [cytosol] (Homo sapiens)
APAF1:ATP [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
APAF1:ATP:CYCS heptamer:p-T125-CASP9 [cytosol] (Homo sapiens)
APAF1:ATP:CYCS [cytosol] (Homo sapiens)
APAF1:ATP [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
UACA binds apoptosome (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS:ATP:CASP9(1-416)dimer [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
UACA:apoptosome [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS:ATP:CASP9(1-416)dimer [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
XIAP binds CASP9 (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
XIAP:apoptosome [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
SMAC, XIAP-regulated apoptotic response (Homo sapiens)
SMAC (DIABLO) binds to IAPs (Homo sapiens)
SMAC binds XIAP within apoptosome (Homo sapiens)
APAF1:CYCS:CASP9:XIAP:DIABLO [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
XIAP:apoptosome [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes (Homo sapiens)
Dissociation of DIABLO:XIAP from the apoptosome complex (Homo sapiens)
APAF1:CYCS:CASP9:XIAP:DIABLO [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
APAF1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14727 APAF1
Gene Names
APAF1, KIAA0413
Chain
chain:1-1248
Reference Genes
BioGPS Gene:317 APAF1
COSMIC (genes):APAF1 APAF1
CTD Gene:317 APAF1
dbSNP Gene:317 APAF1
ENSEMBL:ENSG00000120868 APAF1
HGNC:576 APAF1
KEGG Gene (Homo sapiens):317 APAF1
Monarch:317 APAF1
NCBI Gene:317 APAF1
OMIM:602233 APAF1
UCSC:O14727 APAF1
Reference Transcript
RefSeq:NM_013229.2 APAF1
RefSeq:NM_181869.1 APAF1
RefSeq:NM_181868.1 APAF1
RefSeq:NM_001160.2 APAF1
RefSeq:NM_181861.1 APAF1
Other Identifiers
0001570102
11731156_x_at
11741240_a_at
11741241_a_at
11742201_a_at
16755542
204859_s_at
211553_x_at
211554_s_at
317
3427874
3427875
3427877
3427878
3427879
3427880
3427881
3427883
3427884
3427885
3427886
3427887
3427888
3427889
3427891
3427895
3427896
3427897
3427900
3427902
3427903
3427904
3427905
3427906
3427907
3427909
3427911
3427912
3427913
3427914
3427915
3427916
3427917
3427919
3427921
3427922
3427924
3427927
3427929
3427930
3427932
3427933
3427934
3427935
37227_at
7957759
A_14_P114248
A_14_P133794
A_23_P36611
GE80105
GO:0000166
GO:0001666
GO:0001822
GO:0001843
GO:0002376
GO:0003674
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0006259
GO:0006810
GO:0006915
GO:0006919
GO:0006950
GO:0007049
GO:0007165
GO:0007275
GO:0007399
GO:0007420
GO:0007568
GO:0007584
GO:0008150
GO:0008219
GO:0008635
GO:0008656
GO:0009056
GO:0009790
GO:0010659
GO:0016192
GO:0030154
GO:0030234
GO:0030900
GO:0031072
GO:0031410
GO:0032991
GO:0034641
GO:0034655
GO:0034774
GO:0042802
GO:0042981
GO:0043065
GO:0043167
GO:0043226
GO:0043293
GO:0043312
GO:0043531
GO:0048646
GO:0048856
GO:0051402
GO:0070059
GO:0070062
GO:0070317
GO:0071560
GO:0072432
GO:0097190
GO:0097193
GO:1902510
GO:1904813
GO:2001235
ILMN_1659463
ILMN_2344798
PH_hs_0024223
TC12000765.hg
g13506924_3p_a_at
g4929486_3p_a_at
g7108332_3p_a_at
Participant Of
output
APAF1 gene expression is stimulated by E2F1 and inhibited by E2F6
TP53 stimulates APAF1 gene expression
hasComponent
APAF1:ADP [cytosol]
APAF1:ATP [cytosol]
APAF1:CYCS [cytosol]
Other forms of this molecule
APAF1 [ficolin-1-rich granule lumen]
APAF1 [extracellular region]
APAF1 [secretory granule lumen]
Inferred To
Dark [cytosol] (Drosophila melanogaster)
Apaf1 [cytosol] (Mus musculus)
Apaf1 [cytosol] (Rattus norvegicus)
APAF1 [cytosol] (Gallus gallus)
APAF1 [cytosol] (Sus scrofa)
apaf1 [cytosol] (Danio rerio)
apaf1 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_863651.1
,
NP_001151.1
,
NP_037361.1
,
NP_863659.1
,
NP_863658.1
OpenTargets
ENSG00000120868
GeneCards
O14727
HPA
ENSG00000120868-APAF1
Ensembl
ENST00000333991
,
ENSP00000349862
,
ENSP00000448826
,
ENST00000552268
,
ENSP00000448449
,
ENST00000551964
,
ENSP00000334558
,
ENST00000550527
,
ENSP00000353059
,
ENSP00000449791
,
ENSP00000448165
,
ENST00000357310
,
ENSG00000120868
,
ENST00000359972
,
ENST00000547045
PRO
O14727
PDB
3JBT
,
4RHW
,
2P1H
,
3J2T
,
1CY5
,
5WVC
,
1CWW
,
2YGS
,
5WVE
,
1C15
,
3YGS
,
1Z6T
,
5JUY
HMDB Protein
HMDBP02284
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P55211 CASP9
6
CASP9(1-416) [cytosol]
(R-HSA-57033)
p-T125-CASP9(1-416) [cytosol]
(R-HSA-9627087)
CASP9(331-416) [cytosol]
(R-HSA-141639)
CASP9(?-315) [cytosol]
(R-HSA-141638)
CASP9(1-416) [cytosol]
(R-HSA-114257)
p-S196-CASP9(1-416) [cytosol]
(R-HSA-198636)
0.964
25
UniProt:P62894
4
CYCS [cytosol]
(R-BTA-53259)
AcK-CYCS [mitochondrial intermembrane space]
(R-BTA-5688308)
CYCS [mitochondrial intermembrane space]
(R-BTA-114244)
CYCS [mitochondrial inner membrane]
(R-BTA-352608)
0.736
14
UniProt:P99999 CYCS
4
CYCS [mitochondrial intermembrane space]
(R-HSA-114244)
CYCS [mitochondrial inner membrane]
(R-HSA-352608)
CYCS [cytosol]
(R-HSA-53259)
AcK-CYCS [mitochondrial intermembrane space]
(R-HSA-5688308)
0.688
6
UniProt:P42574 CASP3
5
CASP3(176-277) [nucleoplasm]
(R-HSA-211203)
CASP3(29-175) [nucleoplasm]
(R-HSA-211194)
CASP3(1-277) [cytosol]
(R-HSA-57021)
CASP3(29-175) [cytosol]
(R-HSA-141644)
CASP3(176-277) [cytosol]
(R-HSA-141646)
0.653
7
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.524
2
UniProt:Q9Z0F3 B2L10
0.508
2
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