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APEX1 [nucleoplasm]
Stable Identifier
R-HSA-50119
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
APE1, DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN) (REF-1 protein), DNA-(apurinic or apyrimidinic site) lyase , AP endonuclease 1, APEX nuclease, APEN, REF-1 protein, HAP1
Icon
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
Displacement of DNA glycosylase by APEX1 (Homo sapiens)
Displacement of MBD4 glycosylase by APEX1 at the AP site (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
Displacement of MPG glycosylase by APEX1 at the AP site (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
Displacement of MUTYH glycosylase by APEX1 at the AP site (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
Displacement of OGG1 glycosylase by APEX1 at the AP site (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
Displacement of SMUG1 glycosylase by APEX1 at the AP site (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
Displacement of TDG glycosylase by APEX1 at the AP site (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
Displacement of UNG glycosylase by APEX1 at the AP site (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
Oxidative damage to the AP site (Homo sapiens)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
PCNA-Dependent Long Patch Base Excision Repair (Homo sapiens)
FEN1 bound to PCNA and APEX1 cleaves flap ssDNA (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
LIG1 binds APEX1 and PCNA at SSB (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
LIG1 bound to APEX1 and PCNA ligates SSB (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
POLD,POLE-mediated DNA strand displacement synthesis (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Homo sapiens)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
POLB-Dependent Long Patch Base Excision Repair (Homo sapiens)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
Recruitment of POLB to oxidatively damaged AP site (Homo sapiens)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
Resolution of AP sites via the single-nucleotide replacement pathway (Homo sapiens)
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway (Homo sapiens)
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
Recruitment of POLB to the AP site (Homo sapiens)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P27695 APEX1
Gene Names
APEX1, APE, APE1, APEX, APX, HAP1, REF1
Chain
initiator methionine:, chain:2-318, chain:32-318
Reference Genes
BioGPS Gene:328 APEX1
COSMIC (genes):APEX1 APEX1
COSMIC (genes):HAP1 APEX1
CTD Gene:328 APEX1
dbSNP Gene:328 APEX1
ENSEMBL:ENSG00000100823 APEX1
HGNC:587 APEX1
Monarch:328 APEX1
NCBI Gene:328 APEX1
OMIM:107748 APEX1
UCSC:P27695 APEX1
Reference Transcript
RefSeq:NM_080648.2 APEX1
RefSeq:NM_001244249.1 APEX1
RefSeq:NM_080649.2 APEX1
RefSeq:NM_001641.3 APEX1
Other Identifiers
11715398_a_at
16781516
2025_s_at
210027_PM_s_at
210027_s_at
328
3527495
3527496
3527497
3527498
3527499
3527500
3527501
3527502
3527503
3527504
3527505
3527506
3527507
3527508
3527509
3527510
7973056
A_14_P102533
A_14_P110066
A_14_P114242
A_14_P133179
A_23_P151649
A_23_P151653
D13370_at
GE58776
GE86453
GO:0000723
GO:0000781
GO:0003677
GO:0003684
GO:0003691
GO:0003713
GO:0003714
GO:0003723
GO:0003824
GO:0003906
GO:0004518
GO:0004519
GO:0004520
GO:0004523
GO:0004527
GO:0004528
GO:0004844
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005739
GO:0005783
GO:0005813
GO:0005815
GO:0005840
GO:0006281
GO:0006284
GO:0006287
GO:0006308
GO:0006310
GO:0006325
GO:0006355
GO:0008081
GO:0008296
GO:0008309
GO:0008311
GO:0008408
GO:0016491
GO:0016607
GO:0016787
GO:0016890
GO:0031490
GO:0032200
GO:0042981
GO:0043226
GO:0043488
GO:0044029
GO:0045454
GO:0045892
GO:0045944
GO:0046872
GO:0048471
GO:0052720
GO:0060090
GO:0090580
GO:0097698
GO:0140097
GO:0140098
GO:0140110
GO:0140431
HMNXSV003038159
ILMN_1661886
ILMN_2319344
PH_hs_0004210
TC14000055.hg
g178742_3p_a_at
Participates
as an output of
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Homo sapiens)
LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA (Homo sapiens)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Homo sapiens)
as a component of
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Homo sapiens)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
as an input of
Displacement of TDG glycosylase by APEX1 at the AP site (Homo sapiens)
Displacement of SMUG1 glycosylase by APEX1 at the AP site (Homo sapiens)
Displacement of UNG glycosylase by APEX1 at the AP site (Homo sapiens)
Displacement of MPG glycosylase by APEX1 at the AP site (Homo sapiens)
Displacement of OGG1 glycosylase by APEX1 at the AP site (Homo sapiens)
Displacement of MUTYH glycosylase by APEX1 at the AP site (Homo sapiens)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Homo sapiens)
Displacement of MBD4 glycosylase by APEX1 at the AP site (Homo sapiens)
Inferred To
Ghost homologue of APEX1 [nucleoplasm]
(Schizosaccharomyces pombe)
APEX1 [nucleoplasm]
(Bos taurus)
APEX1 [nucleoplasm]
(Caenorhabditis elegans)
APEX1 [nucleoplasm]
(Canis familiaris)
APEX1 [nucleoplasm]
(Danio rerio)
APEX1 [nucleoplasm]
(Dictyostelium discoideum)
APEX1 [nucleoplasm]
(Drosophila melanogaster)
APEX1 [nucleoplasm]
(Mus musculus)
APEX1 [nucleoplasm]
(Plasmodium falciparum)
APEX1 [nucleoplasm]
(Rattus norvegicus)
APEX1 [nucleoplasm]
(Sus scrofa)
APEX1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
ZINC - World Drugs
APEX1_HUMAN
OpenTargets
ENSG00000100823
ENSEMBL
ENSP00000381111
,
ENSP00000517339
,
ENST00000708794
,
ENSP00000216714
,
ENST00000216714
,
ENST00000398030
,
ENSP00000517343
,
ENSP00000451979
,
ENST00000708795
,
ENST00000708787
,
ENSP00000517342
,
ENST00000555414
ZINC - Substances
APEX1_HUMAN
ZINC - Biogenic
APEX1_HUMAN
ZINC target
P27695
PRO
P27695
GlyGen
P27695
PDB
1BIX
,
6BOU
,
6W3U
,
6BOV
,
4QHE
,
5DFH
,
6BOS
,
7SVB
,
7LPH
,
6W4I
,
6BOR
,
7LPJ
,
1DE9
,
7U50
,
5WN1
,
5WN4
,
7TR7
,
7TC2
,
5WN3
,
6MKM
,
6P94
,
7MCR
,
3U8U
,
5WN0
,
6W3N
,
6W0Q
,
4IEM
,
6MKK
,
4QH9
,
1CQG
,
4QHD
,
1DEW
,
5DFJ
,
5DFI
,
5DG0
,
6MK3
,
6BOT
,
6W43
,
6BOQ
,
7LPI
,
7MEV
,
7LPG
,
5DFF
,
6BOW
,
1DE8
,
2O3H
,
6W3L
,
5WN5
,
7TC3
,
5WN2
,
2ISI
,
6P93
,
5CFG
,
6W3Q
,
7SUV
,
1E9N
,
1HD7
,
6W4T
,
6MKO
,
4LND
,
6W2P
,
1CQH
ZINC - Metabolites
APEX1_HUMAN
IntEnz
3.1.11.2
HPA
ENSG00000100823-APEX1
Pharos - Targets
P27695
ZINC - Predictions - Purchasable
APEX1_HUMAN
HMDB Protein
HMDBP10647
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q09472 EP300
5
EP300 [nucleoplasm]
(R-HSA-381325)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
0.724
8
UniProt:P08107 HSP71
0.702
3
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.619
6
UniProt:Q8N4N3 KLH36
0.564
2
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
5
UniProt:Q16236 NFE2L2
13
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
0.508
3
UniProt:O88846
1
RNF4 [cytosol]
(R-RNO-975974)
0.499
2
IntAct:EBI-2694074 MDM2
0.499
2
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