Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
BAK1 activated [mitochondrial outer membrane]
Stable Identifier
R-HSA-50690
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
Bcl-2 homologous antagonist/killer, Apoptosis regulator BAK, BCL2- like 7 protein
Icon
Locations in the PathwayBrowser for interactor UniProt:P06463 VE6
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation and oligomerization of BAK protein (Homo sapiens)
Oligomerization of BAK at the mitochondrial membrane (Homo sapiens)
BAK1 activated [mitochondrial outer membrane] (Homo sapiens)
tBID activates BAK protein (Homo sapiens)
BAK1 activated [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16611 BAK1
Gene Names
BAK1, BAK, BCL2L7, CDN1
Chain
initiator methionine:, chain:2-211
Reference Genes
BioGPS Gene:578 BAK1
COSMIC (genes):BAK1 BAK1
CTD Gene:578 BAK1
dbSNP Gene:578 BAK1
ENSEMBL:ENSG00000030110 BAK1
ENSEMBL_homo_sapiens_GENE:ENSG00000030110.14 BAK1
HGNC:949 BAK1
KEGG Gene (Homo sapiens):578 BAK1
Monarch:578 BAK1
NCBI Gene:578 BAK1
OMIM:600516 BAK1
UCSC:Q16611 BAK1
Reference Transcript
RefSeq:NM_001188.3 BAK1
RefSeq:XM_011514779.2 BAK1
Other Identifiers
11732515_x_at
11746208_a_at
11748849_a_at
11752413_a_at
1687_s_at
17018274
203728_PM_at
203728_at
2950756
2950757
2950758
2950759
2950760
2950762
2950763
2950764
2950765
2950766
2950768
3398380
578
8125766
846_s_at
A_23_P145357
GE60444
GO:0001776
GO:0001782
GO:0001783
GO:0001836
GO:0001974
GO:0002262
GO:0002352
GO:0002376
GO:0003674
GO:0005215
GO:0005515
GO:0005739
GO:0005741
GO:0005783
GO:0005829
GO:0006915
GO:0006950
GO:0007005
GO:0008053
GO:0008285
GO:0008630
GO:0009410
GO:0009620
GO:0010046
GO:0010225
GO:0010248
GO:0010332
GO:0010524
GO:0010629
GO:0012501
GO:0014070
GO:0015288
GO:0016020
GO:0022414
GO:0023052
GO:0030154
GO:0031018
GO:0031072
GO:0031100
GO:0031334
GO:0031966
GO:0032469
GO:0032471
GO:0033137
GO:0034620
GO:0034644
GO:0035108
GO:0036211
GO:0042542
GO:0042802
GO:0042803
GO:0042981
GO:0043065
GO:0043226
GO:0044325
GO:0044346
GO:0044877
GO:0045471
GO:0045862
GO:0046872
GO:0046902
GO:0046930
GO:0046982
GO:0048597
GO:0048856
GO:0048872
GO:0050673
GO:0051087
GO:0051400
GO:0051604
GO:0051649
GO:0051726
GO:0051881
GO:0055065
GO:0055085
GO:0060068
GO:0060402
GO:0061024
GO:0065003
GO:0070059
GO:0070242
GO:0071260
GO:0090200
GO:0090201
GO:0097136
GO:0097145
GO:0097190
GO:0097192
GO:0097193
GO:0097202
GO:1900103
GO:1901029
GO:1901030
GO:1902262
GO:1903896
GO:2001233
HMNXSV003007423
ILMN_1805990
PH_hs_0005134
TC06001588.hg
U16811_s_at
U16812_s_at
X84213_s_at
g4502362_3p_at
Participates
as an output of
tBID activates BAK protein (Homo sapiens)
as an input of
Oligomerization of BAK at the mitochondrial membrane (Homo sapiens)
as a component of
Active oligomeric BAK [mitochondrial outer membrane] (Homo sapiens)
Other forms of this molecule
BAK1 [mitochondrial outer membrane]
Inferred To
BAK1 [mitochondrial outer membrane]
(Bos taurus)
BAK1 [mitochondrial outer membrane]
(Canis familiaris)
Bak1 [mitochondrial outer membrane]
(Rattus norvegicus)
BAK1 activated [mitochondrial outer membrane]
(Gallus gallus)
BAK1 activated [mitochondrial outer membrane]
(Mus musculus)
BAK1 activated [mitochondrial outer membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001179.1
,
XP_011513081.1
OpenTargets
ENSG00000030110
GeneCards
Q16611
HPA
ENSG00000030110-BAK1
Ensembl
ENST00000374467
,
ENSP00000363591
,
ENST00000442998
,
ENSP00000391258
,
ENSG00000030110
PRO
Q16611
Pharos - Targets
Q16611
PDB
5VWZ
,
2YV6
,
7OFO
,
5FMK
,
8GSV
,
8UKY
,
5FMI
,
8CZH
,
5VX0
,
8IGC
,
5VWY
,
2JBY
,
2IMS
,
7OFM
,
8SRX
,
5AJK
,
7K02
,
6UXN
,
6ODH
,
7M5A
,
8CZF
,
8CZG
,
5VX1
,
6UXM
,
2IMT
,
5VWV
,
2JCN
,
6UXP
,
2LP8
,
1BXL
,
4U2U
,
3QBR
,
4U2V
,
7M5B
,
6UXO
,
2XPX
,
8SRY
,
5VWX
,
6UXR
,
4D2L
,
4UF1
,
2M5B
,
3I1H
,
8IVB
,
5VWW
,
6UXQ
,
7LK4
Interactors (30)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07820 MCL1
1
MCL1 [cytosol]
(R-HSA-5661490)
0.96
19
UniProt:Q07817 BCL2L1
2
BCL2L1 [cytosol]
(R-HSA-50771)
BCL2L1 [mitochondrial outer membrane]
(R-HSA-114236)
0.958
38
UniProt:Q07817-1 BCL2L1
0.942
13
UniProt:Q16611 BAK1
2
BAK1 [mitochondrial outer membrane]
(R-HSA-139896)
BAK1 activated [mitochondrial outer membrane]
(R-HSA-50690)
0.792
5
UniProt:P55957 BID
4
MYS-BID(62-195) [mitochondrial outer membrane]
(R-HSA-114266)
MYS-BID(62-195) [cytosol]
(R-HSA-141373)
BID(1-195) [cytosol]
(R-HSA-50825)
BID(62-195) [cytosol]
(R-HSA-139953)
0.761
4
UniProt:Q07812 BAX
3
BAX [cytosol]
(R-HSA-139916)
BAX activated [cytosol]
(R-HSA-139907)
BAX [mitochondrial outer membrane]
(R-HSA-139949)
0.758
6
UniProt:Q16548 BCL2A1
1
BCL2A1 [cytosol]
(R-HSA-9725307)
0.718
6
UniProt:Q92843 B2CL2
0.718
8
UniProt:P06463 VE6
0.683
5
UniProt:P70444
4
Bid [mitochondrial outer membrane]
(R-MMU-114266)
Bid [cytosol]
(R-MMU-141373)
Bid [cytosol]
(R-MMU-50825)
Bid [cytosol]
(R-MMU-139953)
0.676
3
UniProt:P24356 PG045
0.632
6
UniProt:P97287 MCL1
0.611
3
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.609
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:Q9Y3C5 RNF11
0.556
3
UniProt:Q9UBB4 ATX10
0.556
3
UniProt:O60333-2 KIF1B
0.556
3
UniProt:Q8WXH2 JPH3
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.556
3
UniProt:Q86WV8 Q86WV8
0.556
3
UniProt:P00441 SOD1
5
SOD1 [extracellular region]
(R-HSA-350705)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
SOD1 [cytosol]
(R-HSA-350697)
0.556
3
UniProt:P49810 PSEN2
2
PSEN2(1-297) [plasma membrane]
(R-HSA-201599)
PSEN2(298-448) [plasma membrane]
(R-HSA-9013329)
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:Q05086 UBE3A
1
UBE3A [cytosol]
(R-HSA-976028)
0.544
2
UniProt:P21796 VDAC1
7
PolyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-6783079)
VDAC1 [mitochondrial intermembrane space]
(R-HSA-1267960)
VDAC1 [mitochondrial outer membrane]
(R-HSA-1267988)
Ub-VDAC1 [mitochondrial outer membrane]
(R-HSA-9834989)
K48polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-5205624)
K63polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-9834037)
p-S65-Ub:VDAC1 [mitochondrial outer membrane]
(R-HSA-9834991)
0.544
2
UniProt:Q80U63
5
MFN2 [mitochondrial outer membrane]
(R-MMU-992714)
Ub-MFN2 [mitochondrial outer membrane]
(R-MMU-9835010)
K48polyUb-MFN2 [mitochondrial outer membrane]
(R-MMU-5205668)
K63polyUb-MFN2 [mitochondrial outer membrane]
(R-MMU-9834043)
p-S65-Ub:MFN2 [mitochondrial outer membrane]
(R-MMU-9834980)
0.539
3
UniProt:O95140 MFN2
5
MFN2 [mitochondrial outer membrane]
(R-HSA-992714)
Ub-MFN2 [mitochondrial outer membrane]
(R-HSA-9835010)
K48polyUb-MFN2 [mitochondrial outer membrane]
(R-HSA-5205668)
K63polyUb-MFN2 [mitochondrial outer membrane]
(R-HSA-9834043)
p-S65-Ub:MFN2 [mitochondrial outer membrane]
(R-HSA-9834980)
0.527
2
UniProt:Q8IWA4 MFN1
5
MFN1 [mitochondrial outer membrane]
(R-HSA-992745)
Ub-MFN1 [mitochondrial outer membrane]
(R-HSA-9834985)
p-S65-Ub:MFN1 [mitochondrial outer membrane]
(R-HSA-9835008)
K63polyUb-MFN1 [mitochondrial outer membrane]
(R-HSA-9834040)
K48polyUb-MFN1 [mitochondrial outer membrane]
(R-HSA-5205679)
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text