PXLP-K341-GPT2 transaminates L-Ala to form PYR

Stable Identifier
R-HSA-507775
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT2]
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Glutamic-pyruvate transaminase 2 (alanine aminotransferase 2) (GPT2) catalyzes the reversible reaction of alanine and 2-oxoglutarate (alpha-ketoglutarate) to form pyruvate and glutamate (Yang et al. 2002). Unpublished crystallographic data are consistent with a homodimeric structure for the enzyme with one molecule of pyridoxal phosphate associated with each monomer (PDB 3IHJ). Recent studies of organelles purified from cultured human muscle cells suggest that GPT2 is localized to mitochondria (Glinghammar et al. 2009).

Literature References
PubMed ID Title Journal Year
11863375 cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase

Yang, RZ, Blaileanu, G, Hansen, BC, Shuldiner, AR, Gong, DW

Genomics 2002
19360321 Detection of the mitochondrial and catalytically active alanine aminotransferase in human tissues and plasma

Glinghammar, B, Rafter, I, Lindstrom, AK, Hedberg, JJ, Andersson, HB, Lindblom, P, Berg, AL, Cotgreave, I

Int J Mol Med 2009
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
L-alanine:2-oxoglutarate aminotransferase activity of PXLP-K341-GPT2 dimer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created