Reactome | CHRNA4 [plasma membrane]

CHRNA4 [plasma membrane]

Stable Identifier

R-HSA-507836

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Neuronal acetylcholine receptor subunit alpha-4, ACHA4_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P43681 CHRNA4

Gene Names

CHRNA4, NACRA4

Chain

signal peptide:1-28, chain:29-627

Reference Genes

BioGPS Gene:1137 CHRNA4

COSMIC (genes):CHRNA4 CHRNA4

CTD Gene:1137 CHRNA4

dbSNP Gene:1137 CHRNA4

ENSEMBL:ENSG00000101204 CHRNA4

ENSEMBL_homo_sapiens_GENE:ENSG00000101204.18 CHRNA4

HGNC:1958 CHRNA4

KEGG Gene (Homo sapiens):1137 CHRNA4

Monarch:1137 CHRNA4

NCBI Gene:1137 CHRNA4

OMIM:118504 CHRNA4

UCSC:P43681 CHRNA4

Reference Transcript

Other Identifiers

1137

11737001_at

11749037_a_at

206735_PM_at

206735_at

206736_PM_x_at

206736_x_at

216900_PM_s_at

216900_s_at

3129035

34447_at

3913777

3913778

3913779

3913780

3913781

3913782

3913783

3913784

3913788

3913789

3913790

3913791

3913792

3913795

3913796

3913797

8067610

83355_at

85309_at

A_23_P210395

A_33_P3217584

GE80947

GE825693

GO:0001508

GO:0001666

GO:0002376

GO:0004888

GO:0005215

GO:0005216

GO:0005230

GO:0005515

GO:0005886

GO:0005892

GO:0006281

GO:0006811

GO:0006816

GO:0006979

GO:0007154

GO:0007165

GO:0007268

GO:0007271

GO:0009897

GO:0014059

GO:0015276

GO:0015464

GO:0016020

GO:0019233

GO:0022848

GO:0023052

GO:0030425

GO:0034220

GO:0035094

GO:0035095

GO:0042113

GO:0042166

GO:0042391

GO:0043005

GO:0043025

GO:0045202

GO:0045211

GO:0050877

GO:0050890

GO:0051899

GO:0055085

GO:0060079

GO:0060080

GO:0060089

GO:0110165

HMNXSV003011767

HMNXSV003032913

ILMN_1729857

PH_hs_0001064

PH_hs_0010513

RNA95315|RNS_397_171

U62433_at

g4502826_3p_at

g755647_3p_a_at

Participates

as a member of

acetylcholine receptor subunits [plasma membrane] (Homo sapiens)

as a component of

Inferred To

LOC556619 [plasma membrane] (Danio rerio)

acr-12 [plasma membrane] (Caenorhabditis elegans)

unc-63 [plasma membrane] (Caenorhabditis elegans)

acr-8 [plasma membrane] (Caenorhabditis elegans)

lev-1 [plasma membrane] (Caenorhabditis elegans)

nAChRalpha2 [plasma membrane] (Drosophila melanogaster)

Chrna4 [plasma membrane] (Mus musculus)

Chrna4 [plasma membrane] (Rattus norvegicus)

nAChRalpha3 [plasma membrane] (Drosophila melanogaster)

unc-29 [plasma membrane] (Caenorhabditis elegans)

acr-3 [plasma membrane] (Caenorhabditis elegans)

nAChRalpha4 [plasma membrane] (Drosophila melanogaster)

acr-6 [plasma membrane] (Caenorhabditis elegans)

nAChRbeta2 [plasma membrane] (Drosophila melanogaster)

Homologues of CHRNA4 [plasma membrane] (Caenorhabditis elegans)

Homologues of CHRNA4 [plasma membrane] (Drosophila melanogaster)

acr-2 [plasma membrane] (Caenorhabditis elegans)

CHRNA4 [plasma membrane] (Bos taurus)

CHRNA4 [plasma membrane] (Canis familiaris)

CHRNA4 [plasma membrane] (Gallus gallus)

CHRNA4 [plasma membrane] (Sus scrofa)

lev-8 [plasma membrane] (Caenorhabditis elegans)

nAChRalpha1 [plasma membrane] (Drosophila melanogaster)

nAChRbeta1 [plasma membrane] (Drosophila melanogaster)

unc-38 [plasma membrane] (Caenorhabditis elegans)

chrna4 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001243502.1, NP_000735.1, XP_011526826.1

ZINC - World Drugs

ACHA4_HUMAN

Guide to Pharmacology - Targets

465

OpenTargets

ENSG00000101204

ZINC - FDA approved

ACHA4_HUMAN

ZINC - Substances

ACHA4_HUMAN

ZINC target

P43681

ZINC - Biogenic

ACHA4_HUMAN

PRO

P43681

PDB

2LLY, 6UR8, 6CNK, 6USF, 5KXI, 6CNJ

ZINC - Metabolites

ACHA4_HUMAN

HPA

ENSG00000101204-CHRNA4

GeneCards

P43681

Ensembl

ENSG00000101204, ENSP00000359285, ENST00000370263

Pharos - Targets

P43681

Orphanet

15448

ZINC - Predictions - Purchasable

ACHA4_HUMAN

HMDB Protein

HMDBP12050

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q92673 SORL1	2	SORL1 [endosome membrane] (R-HSA-8871475) SORL1 [Golgi membrane] (R-HSA-8871510)	0.556	3
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.556	3