Reactome: A Curated Pathway Database

STAT5 dimers translocate to the nucleus and bind to specific DNA sequences

Stable Identifier
R-HSA-507937
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Signal transducer and activator of transcription 5A (STAT5A) and Signal transducer and activator of transcription 5B (STAT5B) dimers bind to similar core gamma-interferon activated sequence (GAS) motifs (Soldaini et al., 2000). STAT5A/B also form homo- and hetero-tetramers with distinct or expanded DNA-binding properties. Genes that are regulated by STAT5 include Interleukin-2 receptor alpha (IL2RA) (John et al. 1996), TNFSF11 (RANKL), Connexin-26 (GJB2) and Cyclin D1 (Hennighausen & Robinson, 2005). A comprehensive listing of hepatic STAT5B regulated genes is available from microarray/STAT5B knockout mice (Clodfelter et al. 2006), and similarly for STAT5-dependent genes regulated by the GH receptor (Rowland et al. 2005, Barclay et al. 2011).

Literature References
Participants
Participant Of
Orthologous Events