BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL

Stable Identifier
R-HSA-508162
Type
Reaction [binding]
Species
Homo sapiens
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BH3-only proteins (tBid, BIM, PUMA, BAD, NOXA) associate with and inactivate anti-apoptotic protein Bcl-XL( Yi et al., 2003; Puthalakath et al., 1999; Nakano and Vousden, 2001; Wang et al., 1999; Oda et al., 2000). The interactions of NOXA with Bcl-XL are inferred from experiments performed in mice (Oda et al., 2000).

Literature References
PubMed ID Title Journal Year
10198631 The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

Puthalakath, H, Huang, DC, O'Reilly, LA, King, SM, Strasser, A

Mol Cell 1999
10195903 Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

Wang, HG, Pathan, N, Ethell, IM, Krajewski, S, Yamaguchi, Y, Shibasaki, F, McKeon, F, Bobo, T, Franke, TF, Reed, JC

Science 1999
12624108 Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed

Yi, X, Yin, XM, Dong, Z

J Biol Chem 2003
10807576 Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

Oda, E, Ohki, R, Murasawa, H, Nemoto, J, Shibue, T, Yamashita, T, Tokino, T, Taniguchi, T, Tanaka, N

Science 2000
11463392 PUMA, a novel proapoptotic gene, is induced by p53

Nakano, K, Vousden, KH

Mol Cell 2001
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