Reactome | BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL

BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL

Stable Identifier

R-HSA-508162

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

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BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL

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BH3-only proteins (tBid, BIM, PUMA, BAD, NOXA) associate with and inactivate anti-apoptotic protein Bcl-XL( Yi et al., 2003; Puthalakath et al., 1999; Nakano and Vousden, 2001; Wang et al., 1999; Oda et al., 2000). The interactions of NOXA with Bcl-XL are inferred from experiments performed in mice (Oda et al., 2000).

Literature References

PubMed ID	Title	Journal	Year
10198631	The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex Puthalakath, H, Huang, DC, O'Reilly, LA, King, SM, Strasser, A	Mol Cell	1999
10195903	Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD Wang, HG, Pathan, N, Ethell, IM, Krajewski, S, Yamaguchi, Y, Shibasaki, F, McKeon, F, Bobo, T, Franke, TF, Reed, JC	Science	1999
12624108	Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed Yi, X, Yin, XM, Dong, Z	J Biol Chem	2003
10807576	Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis Oda, E, Ohki, R, Murasawa, H, Nemoto, J, Shibue, T, Yamashita, T, Tokino, T, Taniguchi, T, Tanaka, N	Science	2000
11463392	PUMA, a novel proapoptotic gene, is induced by p53 Nakano, K, Vousden, KH	Mol Cell	2001