a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]

Stable Identifier
R-HSA-508189
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Cytosolic branched-chain-amino-acid aminotransferase (BCAT1) catalyzes the reversible reactions of alpha-ketoisocaproate, alpha-keto-beta-methylvalerate, or a-ketoisovalerate with glutamate to form leucine, isoleucine, or valine, respectively, and alpha-ketoglutarate (2-oxoglutarate). The active enzyme is a homodimer (Goto et al. 2005).
Literature References
PubMed ID Title Journal Year
16141215 Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin

Hirotsu, K, Goto, M, Islam, MM, Conway, ME, Hutson, SM, Yennawar, NH, Miyahara, I

J Biol Chem 2005
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Event Information
Catalyst Activity

branched-chain-amino-acid transaminase activity of BCAT1 dimer [cytosol]

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