Reactome | DNAJB1 [nucleoplasm]

DNAJB1 [nucleoplasm]

Stable Identifier

R-HSA-5082366

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DnaJ homolog subfamily B member 1, HSP40, DnaJ protein homolog 1, Heat shock 40 kDa protein 1, Human DnaJ protein 1, hDj-1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P25685 DNAJB1

Gene Names

DNAJB1, DNAJ1, HDJ1, HSPF1

Chain

initiator methionine:, chain:2-340

Reference Genes

BioGPS Gene:3337 DNAJB1

COSMIC (genes):DNAJB1 DNAJB1

CTD Gene:3337 DNAJB1

dbSNP Gene:3337 DNAJB1

ENSEMBL:ENSG00000132002 DNAJB1

HGNC:5270 DNAJB1

KEGG:hsa:3337 DNAJB1

Monarch:3337 DNAJB1

NCBI Gene:3337 DNAJB1

OMIM:604572 DNAJB1

UCSC:P25685 DNAJB1

Reference Transcript

Other Identifiers

11715445_a_at

11715446_a_at

11751427_a_at

16869653

200664_PM_s_at

200664_s_at

200666_PM_s_at

200666_s_at

231556_PM_at

231556_at

2592568

2592583

2592587

2592591

2592595

3337

3852784

3852785

3852786

3852787

3852788

3852789

3852790

3852791

3852792

3852793

3852794

3852795

3852796

3852797

3852798

3852799

3852800

3852801

3852804

3852806

3852808

3852814

3852817

3852818

54509_at

752_s_at

8034837

A_23_P90062

D85429_at

GE57352

GE711819

GO:0000122

GO:0001671

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006355

GO:0006457

GO:0006986

GO:0014069

GO:0030544

GO:0030900

GO:0032781

GO:0034605

GO:0043025

GO:0043197

GO:0043226

GO:0044183

GO:0045296

GO:0048856

GO:0051082

GO:0051085

GO:0051087

GO:0051117

GO:0060090

GO:0061827

GO:0070062

GO:0090084

GO:0098772

GO:0098794

GO:0098978

GO:0140110

GO:0140416

GO:1900034

HMNXSV003053905

Hs.82646.0.A1_3p_a_at

Hs.98153.0.A1_3p_at

ILMN_1775304

PH_hs_0029012

TC19001239.hg

g5453689_3p_a_at

Participates

as a member of

as a component of

DNAJB1 dimer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

DNAJB1 [cytosol]

p-S149,S151,S171 DNAJB1 [cytosol]

Inferred To

dnajb1 [nucleoplasm] (Xenopus tropicalis)

DNAJB1 [nucleoplasm] (Bos taurus)

DNAJB1 [nucleoplasm] (Canis familiaris)

DNAJB1 [nucleoplasm] (Gallus gallus)

DNAJB1 [nucleoplasm] (Sus scrofa)

Dnajb1 [nucleoplasm] (Mus musculus)

Dnajb1 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of DNAJB1 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of DNAJB1 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of DNAJB1 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of DNAJB1 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of DNAJB1 [nucleoplasm] (Schizosaccharomyces pombe)

dnajb1a [nucleoplasm] (Danio rerio)

Cross References

OpenTargets

ENSG00000132002

ENSEMBL

ENST00000676982, ENST00000254322, ENSP00000471798, ENSP00000470596, ENSP00000503810, ENSP00000472886, ENST00000595992, ENST00000396969, ENSP00000444212, ENSP00000504527, ENSP00000503271, ENST00000678009, ENSP00000504186, ENST00000596853, ENST00000598235, ENST00000596075, ENSP00000504619, ENST00000677762, ENST00000679223, ENSP00000471073, ENSP00000470460, ENSP00000471603, ENSP00000470063, ENST00000601533, ENSP00000254322, ENST00000676515, ENSP00000503027, ENSP00000504352, ENST00000598692, ENST00000677204, ENST00000594099, ENST00000678098

HPA

ENSG00000132002-DNAJB1

PRO

P25685

Pharos - Targets

P25685

GlyGen

P25685

Orphanet

DNAJB1

PDB

3AGZ, 7NDX, 6BYR, 2QLD, 8FEC, 4WB7, 6WJF, 8FE2, 8FE5, 6Z5N, 3AGX, 1HDJ, 6WJG, 3AGY

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14166 TTLL12	1	TTLL12 [cytosol] (R-HSA-8866300)	0.8	7
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.659	3
UniProt:Q9UDY4 DNJB4			0.643	5
UniProt:O75953 DNJB5			0.643	3
UniProt:Q9Y266 NUDC	4	NUDC [cytosol] (R-HSA-377731) NUDC [nucleoplasm] (R-HSA-156716) p-S274,S326-NUDC [cytosol] (R-HSA-156702) p-S274,S326-NUDC [spindle] (R-HSA-9648125)	0.638	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	12
UniProt:Q6P4D5-2 PABIR3			0.556	3
UniProt:P19544-6 WT1			0.556	3
UniProt:Q06547-3 GABPB1	1	NRF2 gamma-1 subunit [nucleoplasm] (R-HSA-1592216)	0.556	3
UniProt:Q03403 TFF2			0.556	3
UniProt:Q06547-2 GABPB1	1	NRF2 beta-2 subunit [nucleoplasm] (R-HSA-1592200)	0.556	3
UniProt:P13051-2 UNG			0.556	3
UniProt:O60907-2 TBL1X			0.556	3
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.527	2
UniProt:Q9BQ87 TBL1Y			0.527	3
UniProt:Q8AZK7 EBNA5			0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.527	2
UniProt:Q99615 DNAJC7	2	DNAJC7 [nucleoplasm] (R-HSA-5255408) DNAJC7 [cytosol] (R-HSA-5252099)	0.527	2
UniProt:P54274 TERF1	1	TERF1 [nucleoplasm] (R-HSA-164618)	0.508	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.499	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	2

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