Reactome | HSPA1L [nucleoplasm]

HSPA1L [nucleoplasm]

Stable Identifier

R-HSA-5082367

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Heat shock 70 kDa protein 1-like, Heat shock 70 kDa protein 1L, HSP70-Hom

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P34931 HSPA1L

Gene Names

HSPA1L

Chain

chain:1-641

Reference Genes

BioGPS Gene:3305 HSPA1L

COSMIC (genes):HSPA1L HSPA1L

CTD Gene:3305 HSPA1L

dbSNP Gene:3305 HSPA1L

ENSEMBL:ENSG00000204390 HSPA1L

ENSEMBL:ENSG00000206383 HSPA1L

ENSEMBL:ENSG00000234258 HSPA1L

ENSEMBL:ENSG00000236251 HSPA1L

HGNC:5234 HSPA1L

KEGG:hsa:3305 HSPA1L

Monarch:3305 HSPA1L

NCBI Gene:3305 HSPA1L

OMIM:140559 HSPA1L

UCSC:P34931 HSPA1L

Reference Transcript

RefSeq:NM_005527.3 HSPA1L

Other Identifiers

11727138_a_at

17017485

17026864

17029337

17032123

17039574

210189_PM_at

210189_at

2949451

2949452

2949453

2949454

2949455

2949456

2949457

3305

40656_at

8125134

8178650

8179848

A_23_P70547

GE57353

GE81523

GO:0002199

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005759

GO:0005829

GO:0005886

GO:0006457

GO:0006986

GO:0007339

GO:0008180

GO:0016787

GO:0016887

GO:0031072

GO:0031625

GO:0031982

GO:0042026

GO:0043226

GO:0044183

GO:0044297

GO:0051082

GO:0051085

GO:0072562

GO:0140657

GO:0140662

GO:1903955

HMNXSV003012431

ILMN_1654566

M59829_at

PH_hs_0004622

TC06001546.hg

TC6_apd_hap1000087.hg

TC6_cox_hap2000173.hg

TC6_dbb_hap3000162.hg

TC6_qbl_hap6000163.hg

g3461865_3p_at

Participates

as a component of

as a member of

Heat shock inducible proteins [nucleoplasm] (Homo sapiens)

as a candidate of

HSPA (HSP70) proteins [nucleoplasm] (Homo sapiens)

Other forms of this molecule

HSPA1L [cytosol]

Inferred To

hspE-2 [nucleoplasm] (Dictyostelium discoideum)

hsp70.3 [nucleoplasm] (Danio rerio)

Ghost homologue of HSPA1L [nucleoplasm] (Xenopus tropicalis)

ssa2 [nucleoplasm] (Schizosaccharomyces pombe)

SSA4 [nucleoplasm] (Saccharomyces cerevisiae)

hsp70.1 [nucleoplasm] (Danio rerio)

SSA3 [nucleoplasm] (Saccharomyces cerevisiae)

ssa1 [nucleoplasm] (Schizosaccharomyces pombe)

HSPA1L [nucleoplasm] (Bos taurus)

HSPA1L [nucleoplasm] (Caenorhabditis elegans)

HSPA1L [nucleoplasm] (Canis familiaris)

HSPA1L [nucleoplasm] (Dictyostelium discoideum)

HSPA1L [nucleoplasm] (Mus musculus)

HSPA1L [nucleoplasm] (Rattus norvegicus)

HSPA1L [nucleoplasm] (Saccharomyces cerevisiae)

HSPA1L [nucleoplasm] (Schizosaccharomyces pombe)

HSPA1L [nucleoplasm] (Sus scrofa)

hspB [nucleoplasm] (Dictyostelium discoideum)

Homologues of HSPA1L [nucleoplasm] (Danio rerio)

Homologues of HSPA1L [nucleoplasm] (Dictyostelium discoideum)

Homologues of HSPA1L [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of HSPA1L [nucleoplasm] (Schizosaccharomyces pombe)

hsp70l [nucleoplasm] (Danio rerio)

SSA2 [nucleoplasm] (Saccharomyces cerevisiae)

SSA1 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_005518.3

Guide to Pharmacology - Targets

2989

ENSEMBL

ENST00000456772, ENSP00000372881, ENST00000417601, ENST00000383390, ENSP00000408347, ENSP00000364805, ENST00000375654, ENSP00000396486

OpenTargets

ENSG00000204390

HPA

ENSG00000204390-HSPA1L

PRO

P34931

Pharos - Targets

P34931

GlyGen

P34931

PDB

3GDQ

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.666	4
UniProt:Q13233 MAP3K1	2	MAP3K1 [cytosol] (R-HSA-166866) p-T1400,T1412-MAP3K1 [cytosol] (R-HSA-2685607)	0.536	2
UniProt:Q15750 TAB1	6	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(445-504) [cytosol] (R-HSA-9729691)	0.536	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.536	2
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.536	2
UniProt:Q00613 HSF1	11	HSF1 [cytosol] (R-HSA-3371452) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) hC36,103-HSF1 [cytosol] (R-HSA-4793916) HSF1 [nucleoplasm] (R-HSA-5082385) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906)	0.508	2
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.483	3

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